PMID- 35683175
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1996-1944 (Print)
IS  - 1996-1944 (Electronic)
IS  - 1996-1944 (Linking)
VI  - 15
IP  - 11
DP  - 2022 May 29
TI  - Bio-Synthesis of Aspergillus terreus Mediated Gold Nanoparticle: Antimicrobial, 
      Antioxidant, Antifungal and In Vitro Cytotoxicity Studies.
LID - 10.3390/ma15113877 [doi]
LID - 3877
AB  - Gold nanoparticles (GNP) were bio-fabricated utilizing the methanolic extract of 
      the endophytic isolate Aspergillus terreus. The biosynthesised gold nanoparticles 
      (GNP023) were characterised using UV-visible spectroscopy (UV-Vis); transmission 
      electron microscopy (TEM), Fourier-transform nfrared spectroscopy (FTIR) and 
      X-ray diffraction (XRD) studies. The bio-fabricated GNP023 displayed a sharp SPR 
      peak at 536 nm, were spherically shaped, and had an average size between 10-16 
      nm. The EDX profile confirmed the presence of gold (Au), and XRD analysis 
      confirmed the crystalline nature of GNP023. The antimicrobial activity of GNP023 
      was investigated against several food-borne and phytopathogens, using in vitro 
      antibacterial and antifungal assays. The maximum zone of inhibition was observed 
      for S. aureus and V. cholera at 400 mug /mL, whereas inhibition in radial mycelial 
      growth was observed against Fusarium oxysporum and Rhizoctonia solani at 52.5% 
      and 65.46%, respectively, when challenged with GNP023 (200 mug/mL). Moreover, the 
      gold nanoparticles displayed significant antioxidant activity against the ABTS 
      radical, with an IC(50) of 38.61 microg/mL, and were non-toxic when tested against 
      human kidney embryonic 293 (HEK293) cells. Thus, the current work supports the 
      application of myco-synthesised gold nanoparticles as a versatile antimicrobial 
      candidate against food-borne pathogens.
FAU - Mishra, Rahul Chandra
AU  - Mishra RC
AD  - TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute (TERI), 
      TERI GRAM, Gurgaon 122001, India.
AD  - Centre for Bioprocessing, School of Life and Environmental Sciences, Deakin 
      University, Waurn Ponds, VIC 3220, Australia.
FAU - Kalra, Rishu
AU  - Kalra R
AD  - TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute (TERI), 
      TERI GRAM, Gurgaon 122001, India.
FAU - Dilawari, Rahul
AU  - Dilawari R
AD  - CSIR-Institute of Microbial Technology, Sector-39-A, Chandigarh 160036, India.
FAU - Goel, Mayurika
AU  - Goel M
AD  - TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute (TERI), 
      TERI GRAM, Gurgaon 122001, India.
FAU - Barrow, Colin J
AU  - Barrow CJ
AUID- ORCID: 0000-0002-2153-7267
AD  - Centre for Bioprocessing, School of Life and Environmental Sciences, Deakin 
      University, Waurn Ponds, VIC 3220, Australia.
LA  - eng
PT  - Journal Article
DEP - 20220529
PL  - Switzerland
TA  - Materials (Basel)
JT  - Materials (Basel, Switzerland)
JID - 101555929
PMC - PMC9181662
OTO - NOTNLM
OT  - Aspergillus sp.
OT  - antibacterial
OT  - antifungal
OT  - endophytic fungi
OT  - gold nanoparticles
COIS- The authors declare no conflict of interest.
EDAT- 2022/06/11 06:00
MHDA- 2022/06/11 06:01
PMCR- 2022/05/29
CRDT- 2022/06/10 01:17
PHST- 2022/04/18 00:00 [received]
PHST- 2022/05/17 00:00 [revised]
PHST- 2022/05/24 00:00 [accepted]
PHST- 2022/06/10 01:17 [entrez]
PHST- 2022/06/11 06:00 [pubmed]
PHST- 2022/06/11 06:01 [medline]
PHST- 2022/05/29 00:00 [pmc-release]
AID - ma15113877 [pii]
AID - materials-15-03877 [pii]
AID - 10.3390/ma15113877 [doi]
PST - epublish
SO  - Materials (Basel). 2022 May 29;15(11):3877. doi: 10.3390/ma15113877.