PMID- 35685451
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1735-3955 (Print)
IS  - 2251-6638 (Electronic)
IS  - 1735-3955 (Linking)
VI  - 17
IP  - 6
DP  - 2021 Nov
TI  - Serum interleukin-18 and its relationship with subclinical atherosclerosis in 
      systemic lupus erythematosus.
PG  - 1-6
LID - 10.22122/arya.v17i0.2126 [doi]
AB  - BACKGROUND: Interleukin-18 (IL-18) is a pro-inflammatory and pro-atherogenic 
      factor, and its blood level has shown a direct correlation with atherosclerosis. 
      We aimed to evaluate the serum IL-18 level in patients with systemic lupus 
      erythematosus (SLE) and its relationship with the intima-media thickness (IMT) of 
      the carotid artery in these patients, as an indicator of atherosclerosis. 
      METHODS: In this cross-sectional study, 60 patients as the patient group and 30 
      healthy volunteers as the control group [matched sex, age, and body mass index 
      (BMI)] were selected, and their disease status and general data were gathered 
      using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) 
      form. A blood sample was also obtained from all participants to determine the 
      serum level of IL-18 and other metrics, including high-sensitivity C-reactive 
      protein (hs-CRP), cholesterol, triglyceride (TG), low-density lipoprotein (LDL), 
      high-density lipoprotein (HDL), anti-double stranded deoxyribonucleic acid 
      (anti-dsDNA), complement 3 (C3), and C4. The IMT of the carotid artery was 
      calculated in both groups. We also evaluated the clinical cardiovascular 
      manifestations. RESULTS: The serum IL-18 levels in patients were significantly 
      higher than in the control group (P < 0.005). It had no significant correlation 
      with disease activity (P = 0.10). The patients with SLE with high IL-18 serum 
      levels (> 280 pg/ml) had higher SLEDAI-2K (P = 0.02) than the patients with a low 
      level (< 280), where 280 was the median of the IL-18 levels. The serum IL-18 
      level had no significant correlation with the carotid artery IMT. CONCLUSION: A 
      high level of IL-18 reflects the disease activity, but it was not significantly 
      correlated with subclinical atherosclerosis, denoted by the carotid artery IMT.
CI  - (c) 2021 Isfahan Cardiovascular Research Center & Isfahan University of Medical 
      Sciences.
FAU - Rezaieyazdi, Zahra
AU  - Rezaieyazdi Z
AD  - Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - AkbariRad, Mina
AU  - AkbariRad M
AD  - Assistant Professor, Department of Internal Medicine, School of Medicine, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Saadati, Nayyereh
AU  - Saadati N
AD  - Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Salari, Masoumeh
AU  - Salari M
AD  - Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Orang, Reza
AU  - Orang R
AD  - Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Sedighi, Sima
AU  - Sedighi S
AD  - Golestan Rheumatology Research Center, Golestan University of Medical Sciences, 
      Gorgan, Iran.
FAU - Esmaily, Habibollah
AU  - Esmaily H
AD  - Department of Epidemiology and Biostatistics, School of Health, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Azarpazhooh, Mahmoud Reza
AU  - Azarpazhooh MR
AD  - Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Firoozi, Abdollah
AU  - Firoozi A
AD  - Pharmacist, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Akbarpour, Ensieh
AU  - Akbarpour E
AD  - Department of Epidemiology and Biostatistics, School of Health, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - ARYA Atheroscler
JT  - ARYA atherosclerosis
JID - 101487337
PMC - PMC9145840
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Interleukin-18
OT  - Systemic Lupus Erythematosus
EDAT- 2022/06/11 06:00
MHDA- 2022/06/11 06:01
PMCR- 2021/11/01
CRDT- 2022/06/10 02:31
PHST- 2020/02/21 00:00 [received]
PHST- 2021/06/30 00:00 [accepted]
PHST- 2022/06/10 02:31 [entrez]
PHST- 2022/06/11 06:00 [pubmed]
PHST- 2022/06/11 06:01 [medline]
PHST- 2021/11/01 00:00 [pmc-release]
AID - ARYA-17-3-2126 [pii]
AID - 10.22122/arya.v17i0.2126 [doi]
PST - ppublish
SO  - ARYA Atheroscler. 2021 Nov;17(6):1-6. doi: 10.22122/arya.v17i0.2126.