PMID- 35685527
OWN - NLM
STAT- MEDLINE
DCOM- 20220613
LR  - 20220716
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Print)
IS  - 1368-5031 (Linking)
VI  - 2022
DP  - 2022
TI  - Probiotic Foods Are Effective on Weight Loss, Biochemical Parameters, and 
      Intestinal Microbiota in Wistar Albino Rats with Obese Microbiota.
PG  - 4569100
LID - 10.1155/2022/4569100 [doi]
LID - 4569100
AB  - The positive effects of various probiotic foods on weight control, intestinal 
      microbiota, and biochemical markers have been proven by various studies. However, 
      there is no study on such effects of tarhana and kefir + tarhana consumption, a 
      type of Turkish food rich in Lactobacillus spp., Pediococcus pentosaceus, 
      Pediococcus acidilactici, and Saccharomyces cerevisiae. This study aimed to 
      determine the changes caused by regular consumption of kefir and/or tarhana for 6 
      months on weight gain, intestinal microbiota, and biochemical parameters in 
      Wistar albino rats with obese microbiota. Therefore, thirty-five rats were fed 
      with five different methods of oral gavage (n = 7 per group): Normal Diet Control 
      (NDC), High Fat Diet Control (HFDC), 6 mL/kg Kefir + High Fat Diet (Kefir + HFD), 
      0.2 g/kg Tarhana + High Fat Diet (Tarhana + HFD), and 6 mL/kg Kefir + 0.2 g/kg 
      Tarhana + High Fat Diet (Kefir + Tarhana + HFD). Normality tests were evaluated 
      using the One-Sample Kolmogorov test and Histogram graph. Multiple group 
      comparisons were performed using one-way ANOVA and Tukey's HSD post hoc test, and 
      the statistical significances were indicated by different letters (p < 0.05). 
      Comparisons by gender were performed using the independent samples t-test. Kefir 
      consumption was more effective on decreasing weight gain. Obese microbiota 
      significantly increased blood glucose level and decreased red blood cell (RBC), 
      hematocrit (HCT), hemoglobin, mean corpuscular hemoglobin (MCH), mean corpuscular 
      hemoglobin concentration (MCHC), platelets (PLT), and white blood cells. RBC and 
      HCT values in Kefir + HFD, PLT value in Tarhana + HFD, and mean corpuscular 
      volume (MCV), MCH, and MCHC values in Kefir + Tarhana + HFD were higher than 
      those of other groups (p < 0.05). Kefir + tarhana consumption significantly 
      showed an increase in blood glucose. Kefir and/or tarhana induced the abundance 
      of Lactobacillus and blocked the abundances of total coliform bacteria and 
      Escherichia coli (p < 0.05). We demonstrated that kefir was effective in 
      decreasing weight gain, and all dietary interventions induced positive 
      alterations on biochemical findings and intestinal microbiota.
CI  - Copyright (c) 2022 Nadide Gizem Tarakci et al.
FAU - Tarakci, Nadide Gizem
AU  - Tarakci NG
AUID- ORCID: 0000-0001-5449-7866
AD  - Department of Nutrition and Dietetics Institute of Health Sciences, Istanbul 
      Medipol University, 34810 Istanbul, Turkey.
FAU - Erdem, Nihal Zekiye
AU  - Erdem NZ
AUID- ORCID: 0000-0001-7046-9515
AD  - Department of Nutrition and Dietetics School of Health Sciences, Istanbul Medipol 
      University, 34083 Istanbul, Turkey.
FAU - Dumen, Emek
AU  - Dumen E
AUID- ORCID: 0000-0001-9389-9382
AD  - Department of Food Hygiene and Technology Faculty of Veterinary Medicine, 
      Istanbul University-Cerrahpasa, 34500 Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220303
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Animals
MH  - Blood Glucose
MH  - Diet, High-Fat
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - *Microbiota
MH  - Obesity
MH  - *Probiotics/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Weight Gain
MH  - Weight Loss
PMC - PMC9159110
COIS- The authors declare no conflicts of interest.
EDAT- 2022/06/11 06:00
MHDA- 2022/06/14 06:00
PMCR- 2022/03/03
CRDT- 2022/06/10 02:32
PHST- 2022/01/07 00:00 [received]
PHST- 2022/02/10 00:00 [revised]
PHST- 2022/02/12 00:00 [accepted]
PHST- 2022/06/10 02:32 [entrez]
PHST- 2022/06/11 06:00 [pubmed]
PHST- 2022/06/14 06:00 [medline]
PHST- 2022/03/03 00:00 [pmc-release]
AID - 10.1155/2022/4569100 [doi]
PST - epublish
SO  - Int J Clin Pract. 2022 Mar 3;2022:4569100. doi: 10.1155/2022/4569100. eCollection 
      2022.