PMID- 35685580
OWN - NLM
STAT- MEDLINE
DCOM- 20220613
LR  - 20220716
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Print)
IS  - 1368-5031 (Linking)
VI  - 2022
DP  - 2022
TI  - The Association of Flow-Mediated Dilatation and Blood Parameters in Primary 
      Raynaud's Phenomenon.
PG  - 9347946
LID - 10.1155/2022/9347946 [doi]
LID - 9347946
AB  - INTRODUCTION: Raynaud's phenomenon (RP) is a multifactorial disorder. If any 
      underlying disease cannot be determined to be responsible for RP, then it is 
      considered to be the primary RP (pRP). We aimed to investigate the differences 
      between laboratory markers and impaired endothelial function in pRP. MATERIALS 
      AND METHODS: Forty-two pRP patients and 30 healthy individuals were included as 
      the study and control groups, respectively. The endothelial function was 
      evaluated with flow-mediated dilatation (FMD) of the brachial artery. The blood 
      samples were obtained from both groups, and white blood cell (WBC), hemoglobin, 
      platelets, mean platelet volume (MPV), creatinine, alanine aminotransferase 
      (ALT), aspartate aminotransferase (AST), D-dimer, fibrinogen, albumin, 
      fibrinogen-to-albumin ratio (FAR), neutrophil-to-lymphocyte ratio (NLR), 
      D-dimer-to-albumin ratio (DDAR), and monocyte chemoattractant protein-1 (MCP-1) 
      parameters were studied. The blood parameters and FMD values obtained were 
      compared between groups. RESULTS: The groups were similar in regard to age, 
      gender, and smoking history (p < 0.05). There was no difference between the two 
      groups in regard to hemoglobin, platelet, MPV, creatinine, ALT, D-dimer, albumin, 
      FAR, NLR, and DDAR levels (p < 0.05). AST levels were slightly higher in the pRP 
      group (p=0.027). Markedly increased WBC, fibrinogen, MPV, and MCP-1 values were 
      detected in the pRP group (p=0.001), as well as higher abnormal FMD responses 
      (p=0.001). There was a direct correlation between abnormal FMD response and serum 
      MCP-1 values in patients with pRP (R: 0.308, R (2): 0.095, p: 0.044). CONCLUSION: 
      It seems to be that MCP-1 levels are higher in patients with pRP, and increased 
      values of MCP-1 levels seem to be related to impaired endothelial functions.
CI  - Copyright (c) 2022 Suheyla Uzun and Ilker Kaya.
FAU - Uzun, Suheyla
AU  - Uzun S
AUID- ORCID: 0000-0003-3570-5361
AD  - Department of Internal Medicine, Gaziosmanpasa University, Tokat, Turkey.
FAU - Kaya, Ilker
AU  - Kaya I
AUID- ORCID: 0000-0001-6222-2133
AD  - Department of Cardiovascular Surgery, Tokat State Hospital, Tokat, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220131
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (Albumins)
RN  - 9001-32-5 (Fibrinogen)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Albumins
MH  - *Brachial Artery
MH  - Creatinine
MH  - Dilatation
MH  - Fibrinogen
MH  - Humans
MH  - *Raynaud Disease
PMC - PMC9159131
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/06/11 06:00
MHDA- 2022/06/14 06:00
PMCR- 2022/01/31
CRDT- 2022/06/10 02:32
PHST- 2021/10/07 00:00 [received]
PHST- 2021/11/30 00:00 [accepted]
PHST- 2022/06/10 02:32 [entrez]
PHST- 2022/06/11 06:00 [pubmed]
PHST- 2022/06/14 06:00 [medline]
PHST- 2022/01/31 00:00 [pmc-release]
AID - 10.1155/2022/9347946 [doi]
PST - epublish
SO  - Int J Clin Pract. 2022 Jan 31;2022:9347946. doi: 10.1155/2022/9347946. 
      eCollection 2022.