PMID- 35686043
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Transcatheter Aortic Valve Implantation: A Report on Serbia's First Systematic 
      Program.
PG  - 882854
LID - 10.3389/fcvm.2022.882854 [doi]
LID - 882854
AB  - INTRODUCTION: Severe aortic stenosis, a highly-common valve disease in the 
      elderly, has a poor prognosis if left untreated. To address the concern of 
      effective procedures for severe aortic stenosis, a systematic TAVI program was 
      established at the Dedinje Cardiovascular Institute (Belgrade, Serbia). METHODS: 
      Our cohort was composed of 56 patients (74+/-15 years old). The mean logistic 
      EuroScore was 10.17%; the mean Society of Thoracic Surgeons score was 3.22%. One 
      third of the patients were categorized as class III or IV of the New York Heart 
      Association (NYHA). The valves selected for use were either self-expandable or 
      balloon expandable (Evolut R, Medtronic; Acurate Neo, Boston Scientific and 
      Myval, Meril). The choice of valve type was made by the Institute's Structural 
      Heart Team, in accordance with the patient's native aortic valve, size and 
      calcification of ilio-femoral vessels, as well as the need for alternative 
      access. TAVI procedure was conducted according to current guidelines provided by 
      the European Society of Cardiology. RESULTS: The procedure success rate was 100%. 
      Trans-femoral approach was achieved in 100% of patients; percutaneously in 87.5%, 
      while a surgical cut was necessary in 12.5%. No patient showed moderate or severe 
      aortic regurgitation after the procedure, although trace or mild regurgitation 
      was recorded in 30.3%. Permanent pacemaker was implanted in one patient (1.78%), 
      contrast induced acute kidney injury occured in one patient (1.78%), no stroke 
      was recorded, and three pseudo-aneurysms which required surgical intervention 
      occurred. Three patients required blood transfusions (5.33%). A 30-day all-cause 
      mortality rate was 1.78%. CONCLUSION: The Dedinje Cardiovascular Institute 
      spearheaded all efforts to establish a TAVI program in Serbia. Our initial TAVI 
      results are promising, encouraging, and comparable with the results of previous 
      large randomized trials. This initial experience opens the door for further 
      development with a goal of our Institute to become a high-volume TAVI center.
CI  - Copyright (c) 2022 Boljevic, Bojic, Farkic, Sagic, Topic, Kovacevic, Lakcevic, 
      Veljkovic, Dobric, Hinic, Ilijevski, Nikolic, Kaludjerovic, Bunc and Nikolic.
FAU - Boljevic, Darko
AU  - Boljevic D
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
FAU - Bojic, Milovan
AU  - Bojic M
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
AD  - School of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina.
FAU - Farkic, Mihajlo
AU  - Farkic M
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
FAU - Sagic, Dragan
AU  - Sagic D
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
AD  - School of Medicine, University of Belgrade, Belgrade, Serbia.
FAU - Topic, Dragan
AU  - Topic D
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
FAU - Kovacevic, Vladimir
AU  - Kovacevic V
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
FAU - Lakcevic, Jovana
AU  - Lakcevic J
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
FAU - Veljkovic, Stefan
AU  - Veljkovic S
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
FAU - Dobric, Milan
AU  - Dobric M
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
AD  - School of Medicine, University of Belgrade, Belgrade, Serbia.
FAU - Hinic, Sasa
AU  - Hinic S
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
FAU - Ilijevski, Nenad
AU  - Ilijevski N
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
AD  - School of Medicine, University of Belgrade, Belgrade, Serbia.
FAU - Nikolic, Marko
AU  - Nikolic M
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
FAU - Kaludjerovic, Aleksandra
AU  - Kaludjerovic A
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
FAU - Bunc, Matjaz
AU  - Bunc M
AD  - University Clinical Center Ljubljana, University of Ljubljana, Ljubljana, 
      Slovenia.
FAU - Nikolic, Aleksandra
AU  - Nikolic A
AD  - Dedinje Cardiovascular Institute, Belgrade, Serbia.
AD  - School of Medicine, University of Belgrade, Belgrade, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20220524
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9170914
OTO - NOTNLM
OT  - TAVI
OT  - TAVI in Serbia
OT  - aortic stenosis
OT  - aortic valve
OT  - structural heart disease interventions
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/11 06:00
MHDA- 2022/06/11 06:01
PMCR- 2022/01/01
CRDT- 2022/06/10 02:40
PHST- 2022/02/24 00:00 [received]
PHST- 2022/04/26 00:00 [accepted]
PHST- 2022/06/10 02:40 [entrez]
PHST- 2022/06/11 06:00 [pubmed]
PHST- 2022/06/11 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.882854 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 May 24;9:882854. doi: 10.3389/fcvm.2022.882854. 
      eCollection 2022.