PMID- 35690090
OWN - NLM
STAT- MEDLINE
DCOM- 20220810
LR  - 20220824
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 213
DP  - 2022 Oct
TI  - Serum concentrations of persistent organic pollutants mixture during pregnancy 
      and anogenital distance in 8-year-old children from the INMA-Asturias cohort.
PG  - 113607
LID - S0013-9351(22)00934-3 [pii]
LID - 10.1016/j.envres.2022.113607 [doi]
AB  - BACKGROUND: During pregnancy, women are commonly exposed to several 
      endocrine-disrupting chemicals, including persistent organic pollutants (POPs). 
      These compounds can transfer to the fetus through the placenta. Prenatal POP 
      exposure is related to altered fetal genital and reproductive tract development. 
      However, the relationship between exposure to POP mixtures and anogenital 
      distance (AGD) is poorly investigated. This study investigated the association 
      between prenatal exposure to POP mixtures and AGD in 8-year-old children. 
      METHODS: Data were collected from the INMA-Asturias cohort. Maternal serum POP 
      concentrations were measured during the first trimester of pregnancy. Anoscrotal 
      distance (AGD(AS)) and anopenile distance (AGD(AP)) in males and anofourchetal 
      distance (AGD(AF)) and anoclitoral distance (AGD(AC)) in females were recorded in 
      362 8-years-olds. Conventional linear regression, and the novel weighted quantile 
      sum regression (WQSR) and Bayesian kernel machine regression (BKMR) models were 
      applied to assess the relationships between AGD and POPs exposure stratified by 
      sex. RESULTS: Among males, in the linear regression, b-hexachlorocyclohexane, 
      PCB138, PCB153, and PCB180 were inversely associated with the anogenital index 
      (AGI)(AS) (-0.06 mm/kg (95% confidence interval [CI]: -0.11, -0.02), -0.07 mm/kg 
      (95% CI: -0.14, -0.01), -0.07 mm/kg (95% CI: -0.13, -0.01), and -0.08 mm/kg (95% 
      CI: -0.14, -0.02), respectively). Among females, polybrominated diphenyl ether 
      (PBDE)47 and PBDE154 were positively associated with increased AGI(AF) 
      (0.02 mm/kg (95% CI: 0.00, 0.03) and 0.09 mm/kg (95% CI: 0.01, 0.17), 
      respectively). BKMR confirmed these associations. WQSR found a negative combined 
      effect of the POP mixture on AGD, and PCB138, PCB153, and PCB180 (weighted 0.18, 
      0.13, and 0.09, respectively) were identified as the most impacting chemicals. In 
      females, WQSR found a positive combined effect and determined PBDE47 (weighted 
      0.35) as the most impacting. CONCLUSIONS: Maternal exposure to a POP mixture was 
      negatively associated with AGD in male children and positively associated with 
      AGD in female children, thus providing evidence of the adverse effects of POPs on 
      genital development.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Garcia-Villarino, Miguel
AU  - Garcia-Villarino M
AD  - Spanish Consortium for Reseaiologrch on Epidemy and Public Health (CIBERESP), 
      Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain; Unidad de Epidemiologia 
      Molecular del Cancer, Instituto Universitario de Oncologia del Principado de 
      Asturias (IUOPA) - Departamento de Medicina, Universidad de Oviedo, Julian 
      Claveria Street s/n, 33006, Oviedo, Asturias, Spain; Instituto de Investigacion 
      Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001, Oviedo, 
      Spain.
FAU - Signes-Pastor, Antonio J
AU  - Signes-Pastor AJ
AD  - Spanish Consortium for Reseaiologrch on Epidemy and Public Health (CIBERESP), 
      Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain; Unidad de Epidemiologia de 
      la Nutricion, Universidad Miguel Hernandez, Alicante, Spain; Instituto de 
      Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Spain.
FAU - Riano-Galan, Isolina
AU  - Riano-Galan I
AD  - Spanish Consortium for Reseaiologrch on Epidemy and Public Health (CIBERESP), 
      Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain; Instituto de Investigacion 
      Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001, Oviedo, 
      Spain; Servicio de Pediatria, Endocrinologia Pediatrica, HUCA, Roma Avenue s/n, 
      33001, Oviedo, Asturias, Spain.
FAU - Rodriguez-Dehli, Ana Cristina
AU  - Rodriguez-Dehli AC
AD  - Instituto de Investigacion Sanitaria del Principado de Asturias (ISPA), Roma 
      Avenue s/n, 33001, Oviedo, Spain; Servicio de Pediatria, Hospital San Agustin, 
      Heros Street, 4, 33410, Aviles, Asturias, Spain.
FAU - Vizcaino, Esther
AU  - Vizcaino E
AD  - Department of Environmental Chemistry, Institute of Environmental Assessment and 
      Water Research (IDAEA-CSIC), Jordi Girona Street, 18-26, 08034, Barcelona, 
      Cataluna, Spain.
FAU - Grimalt, Joan O
AU  - Grimalt JO
AD  - Department of Environmental Chemistry, Institute of Environmental Assessment and 
      Water Research (IDAEA-CSIC), Jordi Girona Street, 18-26, 08034, Barcelona, 
      Cataluna, Spain.
FAU - Fernandez-Somoano, Ana
AU  - Fernandez-Somoano A
AD  - Spanish Consortium for Reseaiologrch on Epidemy and Public Health (CIBERESP), 
      Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain; Unidad de Epidemiologia 
      Molecular del Cancer, Instituto Universitario de Oncologia del Principado de 
      Asturias (IUOPA) - Departamento de Medicina, Universidad de Oviedo, Julian 
      Claveria Street s/n, 33006, Oviedo, Asturias, Spain; Instituto de Investigacion 
      Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001, Oviedo, 
      Spain. Electronic address: fernandezsana@uniovi.es.
FAU - Tardon, Adonina
AU  - Tardon A
AD  - Spanish Consortium for Reseaiologrch on Epidemy and Public Health (CIBERESP), 
      Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain; Unidad de Epidemiologia 
      Molecular del Cancer, Instituto Universitario de Oncologia del Principado de 
      Asturias (IUOPA) - Departamento de Medicina, Universidad de Oviedo, Julian 
      Claveria Street s/n, 33006, Oviedo, Asturias, Spain; Instituto de Investigacion 
      Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001, Oviedo, 
      Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220609
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Anal Canal
MH  - Bayes Theorem
MH  - Child
MH  - Cohort Studies
MH  - *Environmental Pollutants
MH  - Female
MH  - Humans
MH  - Male
MH  - Maternal Exposure
MH  - *Persistent Organic Pollutants
MH  - Pregnancy
OTO - NOTNLM
OT  - Anogenital distance
OT  - BKMR
OT  - Genital development
OT  - Mixtures
OT  - WQSR models
EDAT- 2022/06/12 06:00
MHDA- 2022/08/11 06:00
CRDT- 2022/06/11 19:22
PHST- 2022/03/07 00:00 [received]
PHST- 2022/05/30 00:00 [revised]
PHST- 2022/06/01 00:00 [accepted]
PHST- 2022/06/12 06:00 [pubmed]
PHST- 2022/08/11 06:00 [medline]
PHST- 2022/06/11 19:22 [entrez]
AID - S0013-9351(22)00934-3 [pii]
AID - 10.1016/j.envres.2022.113607 [doi]
PST - ppublish
SO  - Environ Res. 2022 Oct;213:113607. doi: 10.1016/j.envres.2022.113607. Epub 2022 
      Jun 9.