PMID- 35690780
OWN - NLM
STAT- MEDLINE
DCOM- 20220614
LR  - 20220716
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 24
IP  - 1
DP  - 2022 Jun 11
TI  - Associations of C-reactive protein isoforms with systemic lupus erythematosus 
      phenotypes and disease activity.
PG  - 139
LID - 10.1186/s13075-022-02831-9 [doi]
LID - 139
AB  - BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disease 
      characterized by a large production of autoantibodies and deficient clearance of 
      cellular waste. The disease typically oscillates between episodes of elevated 
      disease activity and quiescent disease. C-reactive protein (CRP) is a pentameric 
      acute-phase protein usually reflecting inflammation and tissue damage. However, 
      despite increased inflammation and elevated interleukin-6, the levels of CRP 
      typically remain low or only slightly raised in SLE. Under certain conditions, 
      pentameric CRP (pCRP) can dissociate into its monomeric isoform (mCRP), which 
      mainly has been ascribed pro-inflammatory properties. The present study aims to 
      investigate the potential relationship between pCRP and mCRP, respectively, with 
      disease activity and clinical features of SLE. METHODS: The levels of pCRP and 
      mCRP were measured, by turbidimetry (high-sensitive) and sandwich enzyme-linked 
      immunosorbent assay (ELISA) respectively, in serum samples from 160 patients with 
      SLE and 30 patients with antineutrophil cytoplasmic antibody-associated 
      vasculitis (AAV). Twenty-two of the SLE cases were selected for analysis at two 
      time-points; quiescent disease and active disease. The two CRP isoforms were 
      evaluated in relation to disease activity and clinical features in the two 
      diseases. RESULTS: Levels of pCRP and mCRP were significantly lower in SLE than 
      AAV (p < 0.001) and the ratio of mCRP/pCRP was higher in SLE compared to AAV. The 
      mCRP/pCRP ratio was higher for patients in remission and able to significantly 
      separate between active/quiescent disease in paired, but not in non-paired, 
      samples from patients with SLE. Significant correlations were observed with 
      SLICC/ACR damage index for pCRP levels as well as inversely with the mCRP/pCRP 
      ratio. Lower mCRP levels associated with malar rash. CONCLUSION: As the 
      interrelationship between the two isoforms appear to (a) discriminate between 
      quiescent and active SLE and (b) differ between SLE and AAV, our data indicates 
      that the two CRP isoforms could exert contrasting immunological effects and/or 
      reflect different milieus. Given the biological effects of mCRP, it is possible 
      that altered levels may indicate increased opsonization of immune complexes and 
      apoptotic debris, and thereby prevent their deposition outside the 
      reticuloendothelial system and manifestations such as lupus nephritis and 
      lupus-related skin disease.
CI  - (c) 2022. The Author(s).
FAU - Karlsson, Jesper
AU  - Karlsson J
AUID- ORCID: 0000-0002-7045-146X
AD  - Department of Biomedical and Clinical Sciences, Division of Inflammation and 
      Infection/Rheumatology, Linkoping University, Campus US, 581 85, Linkoping, 
      Sweden. jesper.karlsson@liu.se.
FAU - Wettero, Jonas
AU  - Wettero J
AD  - Department of Biomedical and Clinical Sciences, Division of Inflammation and 
      Infection/Rheumatology, Linkoping University, Campus US, 581 85, Linkoping, 
      Sweden.
FAU - Weiner, Maria
AU  - Weiner M
AD  - Department of Nephrology in Linkoping, Department of Health, Medicine and Caring 
      Sciences, Linkoping University, Linkoping, Sweden.
FAU - Ronnelid, Johan
AU  - Ronnelid J
AD  - Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, 
      Sweden.
FAU - Fernandez-Botran, Rafael
AU  - Fernandez-Botran R
AD  - Department of Pathology & Laboratory Medicine, University of Louisville, 
      Louisville, KY, USA.
FAU - Sjowall, Christopher
AU  - Sjowall C
AD  - Department of Biomedical and Clinical Sciences, Division of Inflammation and 
      Infection/Rheumatology, Linkoping University, Campus US, 581 85, Linkoping, 
      Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220611
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
RN  - 0 (Protein Isoforms)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - *C-Reactive Protein/metabolism
MH  - Humans
MH  - Inflammation
MH  - *Lupus Erythematosus, Systemic/diagnosis
MH  - Phenotype
MH  - Protein Isoforms
PMC - PMC9188243
OTO - NOTNLM
OT  - Acute-phase protein
OT  - Biomarker
OT  - C-reactive protein
OT  - Complement
OT  - Inflammation
OT  - Pentraxin
OT  - Systemic lupus erythematosus
OT  - Vasculitis
COIS- The authors declare that they have no competing interests.
EDAT- 2022/06/12 06:00
MHDA- 2022/06/15 06:00
PMCR- 2022/06/11
CRDT- 2022/06/11 23:36
PHST- 2021/10/20 00:00 [received]
PHST- 2022/06/02 00:00 [accepted]
PHST- 2022/06/11 23:36 [entrez]
PHST- 2022/06/12 06:00 [pubmed]
PHST- 2022/06/15 06:00 [medline]
PHST- 2022/06/11 00:00 [pmc-release]
AID - 10.1186/s13075-022-02831-9 [pii]
AID - 2831 [pii]
AID - 10.1186/s13075-022-02831-9 [doi]
PST - epublish
SO  - Arthritis Res Ther. 2022 Jun 11;24(1):139. doi: 10.1186/s13075-022-02831-9.