PMID- 35692546
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 9
DP  - 2022
TI  - Differential Effect of Generalized and Abdominal Obesity on the Development and 
      Progression of Diabetic Retinopathy in Chinese Adults With Type 2 Diabetes.
PG  - 774216
LID - 10.3389/fmed.2022.774216 [doi]
LID - 774216
AB  - BACKGROUND: The relationship between obesity and diabetic retinopathy (DR) 
      remains controversial. The aim of this study was to assess the association of 
      generalized obesity [assessed by body mass index (BMI)] and abdominal obesity 
      [assessed by waist to hip ratio (WHR)] with incident DR, and vision-threatening 
      DR (VTDR), and DR progression among Chinese adults with type 2 diabetic mellitus 
      (T2DM). METHOD: This prospective cohort study was conducted at the Zhongshan 
      Ophthalmic Center, from November 2017 to December 2020. DR was assessed based on 
      the 7-filed fundus photographs using the modified Airlie House Classification. 
      Multivariable logistic regression models were used to evaluate the associations 
      of BMI and WHR with the development and progression of DR after adjusting for 
      age, sex, traditional risk factors, and mutually for BMI and WHR. RESULTS: Among 
      the 1,370 eligible participants, 1,195 (87.2%) had no sign of any DR and 175 
      (12.8%) had DR at baseline examination. During the 2 years follow-up visit, 342 
      (28.6%) participants had incident DR, 11 (0.8%) participants developed VTDR, 15 
      (8.6%) demonstrated DR progression. After adjusting for confounders, the BMI was 
      negatively associated with incident DR [relative risk (RR) =0.31; 95% confidence 
      interval (CI), 0.26-0.38; P < 0.001] and incident VTDR (RR = 0.22; 95%CI, 
      0.11-0.43; P < 0.001), while WHR was positively associated with incident DR (RR = 
      1.47; 95% CI, 1.27-1.71; P < 0.001). BMI and WHR level were not significantly 
      associated with 2-year DR progression in multivariate models (all P > 0.05). 
      CONCLUSIONS: This study provides longitudinal evidence that generalized obesity 
      confer a protective effect on DR, while abdominal obesity increased the risk of 
      DR onset in Chinese patients, indicating that abdominal obesity is a more 
      clinically relevant risk marker of DR than generalized obesity.
CI  - Copyright (c) 2022 Han, Wu, Li, Yuan, Gong, Guo, Tan, Xie, Liang, Huang, Liu and 
      Wang.
FAU - Han, Xiaoyan
AU  - Han X
AD  - The First People's Hospital of Zhaoqing, Zhaoqing, China.
FAU - Wu, Huimin
AU  - Wu H
AD  - Shenzhen Children's Hospital, Shenzhen, China.
FAU - Li, Youjia
AU  - Li Y
AD  - The First People's Hospital of Zhaoqing, Zhaoqing, China.
FAU - Yuan, Meng
AU  - Yuan M
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual 
      Science, Guangdong Provincial Clinical Research Center for Ocular Disease, 
      Guangzhou, China.
FAU - Gong, Xia
AU  - Gong X
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual 
      Science, Guangdong Provincial Clinical Research Center for Ocular Disease, 
      Guangzhou, China.
FAU - Guo, Xiao
AU  - Guo X
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual 
      Science, Guangdong Provincial Clinical Research Center for Ocular Disease, 
      Guangzhou, China.
FAU - Tan, Rongqiang
AU  - Tan R
AD  - The First People's Hospital of Zhaoqing, Zhaoqing, China.
FAU - Xie, Ming
AU  - Xie M
AD  - The First People's Hospital of Zhaoqing, Zhaoqing, China.
FAU - Liang, Xiaoling
AU  - Liang X
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual 
      Science, Guangdong Provincial Clinical Research Center for Ocular Disease, 
      Guangzhou, China.
FAU - Huang, Wenyong
AU  - Huang W
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual 
      Science, Guangdong Provincial Clinical Research Center for Ocular Disease, 
      Guangzhou, China.
FAU - Liu, Hua
AU  - Liu H
AD  - Department of Ophthalmology, Third Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou, China.
FAU - Wang, Lanhua
AU  - Wang L
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual 
      Science, Guangdong Provincial Clinical Research Center for Ocular Disease, 
      Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20220527
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC9184733
OTO - NOTNLM
OT  - abdominal obesity
OT  - body mass index
OT  - cohort
OT  - diabetic retinopathy
OT  - generalized obesity
OT  - waist to hip ratio
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The handling editor ZL declared a shared affiliation with 
      the authors XGu, XGo, XL, WH, MY, and LW at the time of review.
EDAT- 2022/06/14 06:00
MHDA- 2022/06/14 06:01
PMCR- 2022/05/27
CRDT- 2022/06/13 02:59
PHST- 2021/09/11 00:00 [received]
PHST- 2022/04/25 00:00 [accepted]
PHST- 2022/06/13 02:59 [entrez]
PHST- 2022/06/14 06:00 [pubmed]
PHST- 2022/06/14 06:01 [medline]
PHST- 2022/05/27 00:00 [pmc-release]
AID - 10.3389/fmed.2022.774216 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2022 May 27;9:774216. doi: 10.3389/fmed.2022.774216. 
      eCollection 2022.