PMID- 35692727
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 10
IP  - 69
DP  - 2020 Nov 17
TI  - Paeoniflorin ameliorates glycemic variability-induced oxidative stress and 
      platelet activation in HUVECs and DM rats.
PG  - 42605-42612
LID - 10.1039/d0ra02036b [doi]
AB  - Glycemic variability (GV) plays an important role in the pathogenesis of vascular 
      complications associated with diabetes mellitus (DM). Paeoniflorin is an 
      effective Chinese traditional medicine with anti-inflammatory and 
      immune-regulatory effects. Previous studies implicated the beneficial effects of 
      paeoniflorin in treatment for diabetic complications, such as type 2 diabetic 
      nephropathy and diabetes with myocardial ischemic injury. Current evidence 
      suggests that oxidative stress and platelet activation, as well as their 
      interaction, are potentially associated with GV and involved in the pathogenesis 
      of diabetes-associated vascular complications. This study aimed to explore the 
      effects of paeoniflorin on oxidative stress and platelet activation, using human 
      umbilical vein endothelial cells (HUVECs) cultured with different glucose 
      concentrations, and streptozotocin-induced diabetic rats fed different glycemic 
      index diets. Paeoniflorin treatment effectively improved the morphology and cell 
      viability of HUVECs under glucose fluctuation. Moreover, the platelet aggregation 
      rate, CD62p expression, and reactive oxygen species (ROS) concentration 
      decreased, while glutathione peroxidase (GSH-px) levels increased in 
      paeoniflorin-treated groups. In conclusion, our study found that paeoniflorin 
      ameliorates oxidative stress and platelet activation induced by glycemic 
      variability both in vivo and in vitro, suggesting a novel potential strategy for 
      treatment of diabetic complications.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Huang, Ye
AU  - Huang Y
AUID- ORCID: 0000-0002-8691-4924
AD  - Emergency Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences 
      Beijing 100091 China yangzhixu@sohu.com +86 10 62835314 +86 10 62835314.
FAU - Wang, Jing-Shang
AU  - Wang JS
AD  - Department of Traditional Chinese Medicine, Beijing Obstetrics and Gynecology 
      Hospital, Capital Medical University Beijing 100026 China.
FAU - Yang, Lin
AU  - Yang L
AD  - Department of Cardiovascular Disease, Xiyuan Hospital, China Academy of Chinese 
      Medical Sciences Beijing 100091 China.
FAU - Yue, Long
AU  - Yue L
AD  - Emergency Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences 
      Beijing 100091 China yangzhixu@sohu.com +86 10 62835314 +86 10 62835314.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Emergency Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences 
      Beijing 100091 China yangzhixu@sohu.com +86 10 62835314 +86 10 62835314.
FAU - Zhang, Yan-Hong
AU  - Zhang YH
AD  - Emergency Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences 
      Beijing 100091 China yangzhixu@sohu.com +86 10 62835314 +86 10 62835314.
FAU - Song, Ye-Wen
AU  - Song YW
AD  - Emergency Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences 
      Beijing 100091 China yangzhixu@sohu.com +86 10 62835314 +86 10 62835314.
FAU - Li, Dandan
AU  - Li D
AD  - Institute of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences Beijing 100091 China.
FAU - Yang, Zhixu
AU  - Yang Z
AD  - Emergency Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences 
      Beijing 100091 China yangzhixu@sohu.com +86 10 62835314 +86 10 62835314.
LA  - eng
PT  - Journal Article
DEP - 20201124
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
PMC - PMC9119283
COIS- There are no conflicts to declare.
EDAT- 2020/11/24 00:00
MHDA- 2020/11/24 00:01
PMCR- 2020/11/24
CRDT- 2022/06/13 03:03
PHST- 2020/03/03 00:00 [received]
PHST- 2020/06/21 00:00 [accepted]
PHST- 2022/06/13 03:03 [entrez]
PHST- 2020/11/24 00:00 [pubmed]
PHST- 2020/11/24 00:01 [medline]
PHST- 2020/11/24 00:00 [pmc-release]
AID - d0ra02036b [pii]
AID - 10.1039/d0ra02036b [doi]
PST - epublish
SO  - RSC Adv. 2020 Nov 24;10(69):42605-42612. doi: 10.1039/d0ra02036b. eCollection 
      2020 Nov 17.