PMID- 35693139
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2008-126X (Print)
IS  - 2228-7442 (Electronic)
IS  - 2008-126X (Linking)
VI  - 12
IP  - 6
DP  - 2021 Nov-Dec
TI  - Modulatory Effects of Memantine on Neuronal Response Properties in Rat Barrel 
      Cortex.
PG  - 721-728
LID - 10.32598/bcn.2021.1156.2 [doi]
AB  - INTRODUCTION: Memantine as N-Methyl-D-Aspartic Acid (NMDA) receptor antagonist is 
      used in some neurological disorders. Moreover, memantine presents modulatory 
      effects on the somatosensory information processing in healthy subjects. This 
      study investigated the effects of memantine on electrophysiological properties of 
      barrel cortex neurons in male rats. METHODS: Single unit recording was used to 
      evaluate the electrophysiological properties of barrel cortex neurons. The neural 
      responses to the Principal Whisker (PW), Adjacent Whisker (AW), and combined 
      displacement of two whiskers [20 ms Inter-Stimulus Intervals (ISIs)] were 
      recorded before and 2 hours after memantine gavage (10 mg/kg). A Condition Test 
      Ratio (CTR) was calculated for assessing inhibitory interactions. RESULTS: Two 
      hours after memantine gavage, neuronal ON and OFF responses to PW deflection were 
      decreased. Furthermore, CTR for both ON and OFF responses was decreased following 
      memantine administration. CONCLUSION: The current study demonstrated that 
      memantine modified neural response properties in the rat barrel cortex. 
      HIGHLIGHTS: Memantine modulated excitatory receptive fields in the rat 
      somatosensory cortex.Memantine decreased integrative receptive fields in rat 
      somatosensory cortex. PLAIN LANGUAGE SUMMARY: As an NMDA receptor antagonist, 
      memantine is used to treat moderate to severe Alzheimer's disease. Memantine has 
      beneficial effects on cognition, mood, and perform daily activities. However, the 
      current study results suggested that memantine may affect information processing 
      in the somatosensory system. This should be considered for future research in the 
      clinic.
CI  - Copyright(c) 2021 Iranian Neuroscience Society.
FAU - Nasiri, Mahin
AU  - Nasiri M
AUID- ORCID: 0000-0002-2378-9732
AD  - Physiology-Pharmacology Research Center, Research Institute of Basic Medical 
      Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
FAU - Kaeidi, Ayat
AU  - Kaeidi A
AUID- ORCID: 0000-0002-3292-2603
AD  - Physiology-Pharmacology Research Center, Research Institute of Basic Medical 
      Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
AD  - Department of Physiology and Pharmacology, School of Medicine, Rafsanjan 
      University of Medical Sciences, Rafsanjan, Iran.
FAU - Fatemi, Iman
AU  - Fatemi I
AUID- ORCID: 0000-0002-9666-9651
AD  - Research Center of Tropical and Infectious Diseases, Kerman University of Medical 
      Sciences, Kerman, Iran.
FAU - Azin, Mahdieh
AU  - Azin M
AUID- ORCID: 0000-0003-4111-7806
AD  - Physiology-Pharmacology Research Center, Research Institute of Basic Medical 
      Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
AD  - Department of Physiology and Pharmacology, School of Medicine, Rafsanjan 
      University of Medical Sciences, Rafsanjan, Iran.
FAU - Bannazadeh, Mahboobeh
AU  - Bannazadeh M
AUID- ORCID: 0000-0003-4779-578X
AD  - Physiology-Pharmacology Research Center, Research Institute of Basic Medical 
      Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
FAU - Allahtavakoli, Mohammad
AU  - Allahtavakoli M
AUID- ORCID: 0000-0002-7593-7768
AD  - Physiology-Pharmacology Research Center, Research Institute of Basic Medical 
      Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
AD  - Department of Physiology and Pharmacology, School of Medicine, Rafsanjan 
      University of Medical Sciences, Rafsanjan, Iran.
FAU - Roohbakhsh, Ali
AU  - Roohbakhsh A
AUID- ORCID: 0000-0001-5032-4263
AD  - Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Shamsizadeh, Ali
AU  - Shamsizadeh A
AUID- ORCID: 0000-0001-8329-9156
AD  - Physiology-Pharmacology Research Center, Research Institute of Basic Medical 
      Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
AD  - Department of Physiology and Pharmacology, School of Medicine, Rafsanjan 
      University of Medical Sciences, Rafsanjan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20211101
PL  - Iran
TA  - Basic Clin Neurosci
JT  - Basic and clinical neuroscience
JID - 101575211
PMC - PMC9168817
OTO - NOTNLM
OT  - Electrophysiology
OT  - Memantine
OT  - Rat
OT  - Somatosensory cortex
COIS- Conflict of interest The authors declared no conflict of interest.
EDAT- 2022/06/14 06:00
MHDA- 2022/06/14 06:01
PMCR- 2021/11/01
CRDT- 2022/06/13 03:11
PHST- 2019/05/16 00:00 [received]
PHST- 2019/09/25 00:00 [revised]
PHST- 2019/12/02 00:00 [accepted]
PHST- 2022/06/13 03:11 [entrez]
PHST- 2022/06/14 06:00 [pubmed]
PHST- 2022/06/14 06:01 [medline]
PHST- 2021/11/01 00:00 [pmc-release]
AID - bcn-12-721 [pii]
AID - 10.32598/bcn.2021.1156.2 [doi]
PST - ppublish
SO  - Basic Clin Neurosci. 2021 Nov-Dec;12(6):721-728. doi: 10.32598/bcn.2021.1156.2. 
      Epub 2021 Nov 1.