PMID- 35693367
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 5
DP  - 2022 May
TI  - Safety and Efficacy of Injecting Mesenchymal Stem Cells Into a Human Knee Joint 
      To Treat Osteoarthritis: A Systematic Review.
PG  - e24823
LID - 10.7759/cureus.24823 [doi]
LID - e24823
AB  - Intraarticular stem cell therapy has become increasingly used to treat knee 
      osteoarthritis (KOA) with minimal high-quality evidence to support its use. This 
      study aims to see how well intra-articular injections of mesenchymal stem cells 
      (MSCs) worked and how safe they were for individuals with KOA. A total of 10 
      studies were extracted using PubMed, Cochrane Library, and PMC from 2017 to 2021 
      in the English language. An assessment of the risk of bias was applied via the 
      Cochrane Collaborative Bias Risk Tool and Newcastle-Ottawa Quality. Changes in 
      pain and functional outcomes in patients with KOA were measured by a Knee injury 
      and Osteoarthritis Outcome Score (KOOS) scores, Visual Analogue Scale (VAS), 
      Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores at 
      baseline, and follow-up evaluation criteria. The magnetic resonance imaging (MRI) 
      was evaluated using the whole-organ magnetic resonance imaging score (WORMS) and 
      cartilage volume changes. A total of six randomized controlled trials (RCTs), 
      three prospective retrospective clinical trials, and one retrospective clinical 
      trial included 723 patients. They were diagnosed with unilateral or bilateral KOA 
      with Kellgren-Lawrence (KL) grade 1-4 KOA and followed up for six, 12, and 24 
      months. The experimental groups received multipotent MSCs, mesenchymal progenitor 
      cells (MPCs), adipose tissue progenitor stem cells (AD-MPCs), adipose tissue 
      mesenchymal stem cells (AD-MSCs), bone marrow mesenchymal stem cells (BM-MSCs), 
      bone marrow aspiration (BMA), bone marrow aspiration concentration (BMAC), or 
      micro fragmented adipose tissue (MFAT) while the controlled groups received 
      normal saline (NS), hyaluronic acid (HA), placebo, or went through conservative 
      management. In conclusion, significant improvements were noticed in the MSCs 
      groups via different outcome measuring tools like KOOS, VAS, WOMAC, and MRI. 
      Furthermore, no significant adverse events (AEs) have been observed. Therefore, 
      intra-articular injections of MSCs are effective and safe in relieving pain and 
      improving motor function in individuals with KOA in the short term, contrary to 
      earlier research findings.
CI  - Copyright (c) 2022, Shoukrie et al.
FAU - Shoukrie, Shoukrie I
AU  - Shoukrie SI
AD  - Orthopaedics and Traumatology, California Institute of Behavioral Neurosciences & 
      Psychology, Fairfield, USA.
FAU - Venugopal, Sathish
AU  - Venugopal S
AD  - Neurosurgery, California Institute of Behavioral Neurosciences & Psychology, 
      Fairfield, USA.
FAU - Dhanoa, Ravneet K
AU  - Dhanoa RK
AD  - Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, 
      Fairfield, USA.
FAU - Selvaraj, Ramaneshwar
AU  - Selvaraj R
AD  - Family Medicine, California Institute of Behavioral Neurosciences & Psychology, 
      Fairfield, USA.
FAU - Selvamani, Tharun Y
AU  - Selvamani TY
AD  - Surgery, California Institute of Behavioral Neurosciences & Psychology, 
      Fairfield, USA.
FAU - Zahra, Anam
AU  - Zahra A
AD  - Surgery, California Institute of Behavioral Neurosciences & Psychology, 
      Fairfield, USA.
FAU - Malla, Jyothirmai
AU  - Malla J
AD  - Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, 
      Fairfield, USA.
FAU - Hamouda, Ranim K
AU  - Hamouda RK
AD  - Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, 
      Fairfield, USA.
FAU - Hamid, Pousette F
AU  - Hamid PF
AD  - Neurology, California Institute of Behavioral Neurosciences & Psychology, 
      Fairfield, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220508
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9172807
OTO - NOTNLM
OT  - injection
OT  - intra-articular
OT  - knee
OT  - mesenchymal stem cells
OT  - osteoarthritis
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/06/14 06:00
MHDA- 2022/06/14 06:01
PMCR- 2022/05/08
CRDT- 2022/06/13 03:14
PHST- 2022/03/21 00:00 [received]
PHST- 2022/05/08 00:00 [accepted]
PHST- 2022/06/13 03:14 [entrez]
PHST- 2022/06/14 06:00 [pubmed]
PHST- 2022/06/14 06:01 [medline]
PHST- 2022/05/08 00:00 [pmc-release]
AID - 10.7759/cureus.24823 [doi]
PST - epublish
SO  - Cureus. 2022 May 8;14(5):e24823. doi: 10.7759/cureus.24823. eCollection 2022 May.