PMID- 35693469
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2516-8290 (Electronic)
IS  - 2516-8290 (Linking)
VI  - 4
IP  - 3
DP  - 2022
TI  - Successful treatment of vancomycin-resistant enterococcal infection of an 
      external ventricular drain with 2 weeks of intravenous linezolid.
PG  - 000335
LID - 10.1099/acmi.0.000335 [doi]
LID - 000335
AB  - Hydrocephalus is a common condition worldwide, and is frequently managed by 
      diversion of cerebrospinal fluid (CSF), either externally with a drain or 
      internally with a shunt. An external ventricular drain (EVD) can be an essential 
      treatment modality, but is associated with a risk of infection, most commonly 
      caused by Staphylococcal species, which can result in meningitis or ventriculitis 
      and a delay in the definitive management of the hydrocephalus. Here, we report 
      the case of a patient who required an EVD to manage post-operative hydrocephalus 
      following a craniotomy and microvascular decompression for trigeminal neuralgia. 
      He subsequently developed EVD-associated infection with a vancomycin-resistant 
      Enterococcus faecium (VRE), which was treated successfully with a 2-week course 
      of intravenous linezolid monotherapy. The authors believe this to be the only 
      described case of successful treatment within this time frame of a CSF VRE 
      infection associated with indwelling foreign material.
CI  - (c) 2022 The Authors.
FAU - Cearns, Michael D
AU  - Cearns MD
AUID- ORCID: 0000-0002-1479-8979
AD  - Department of Neurosurgery, Institute of Neurological Sciences, 1345 Govan Road, 
      Glasgow G51 4TF, UK.
FAU - McLintock, Bruce T
AU  - McLintock BT
AUID- ORCID: 0000-0002-5381-0176
AD  - Department of Medical Microbiology, Queen Elizabeth University Hospital, 1345 
      Govan Road, Glasgow G51 4TF, UK.
FAU - Suttner, Nigel
AU  - Suttner N
AUID- ORCID: 0000-0002-4784-7271
AD  - Department of Neurosurgery, Institute of Neurological Sciences, 1345 Govan Road, 
      Glasgow G51 4TF, UK.
FAU - Khalsa, Kamaljit
AU  - Khalsa K
AUID- ORCID: 0000-0003-3735-8615
AD  - Department of Medical Microbiology, Queen Elizabeth University Hospital, 1345 
      Govan Road, Glasgow G51 4TF, UK.
LA  - eng
PT  - Case Reports
DEP - 20220329
PL  - England
TA  - Access Microbiol
JT  - Access microbiology
JID - 101746927
PMC - PMC9175973
OTO - NOTNLM
OT  - external ventricular drain
OT  - hydrocephalus
OT  - linezolid
OT  - vancomycin-resistant enterococcus
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2022/06/14 06:00
MHDA- 2022/06/14 06:01
PMCR- 2022/03/29
CRDT- 2022/06/13 03:16
PHST- 2021/02/16 00:00 [received]
PHST- 2022/01/24 00:00 [accepted]
PHST- 2022/06/13 03:16 [entrez]
PHST- 2022/06/14 06:00 [pubmed]
PHST- 2022/06/14 06:01 [medline]
PHST- 2022/03/29 00:00 [pmc-release]
AID - 000335 [pii]
AID - 10.1099/acmi.0.000335 [doi]
PST - epublish
SO  - Access Microbiol. 2022 Mar 29;4(3):000335. doi: 10.1099/acmi.0.000335. 
      eCollection 2022.