PMID- 35694239
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230916
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2022
DP  - 2022
TI  - Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation-Related 
      Tumorigenesis via Modulating Macrophages.
PG  - 1617229
LID - 10.1155/2022/1617229 [doi]
LID - 1617229
AB  - Mesenchymal stem cells (MSCs) have been documented to be effective for the 
      therapy of inflammation-related diseases but raised concerns on possible 
      tumorigenic effects. Since most of the tumors are induced or promoted by chronic 
      inflammation, one could expect that MSCs might be beneficial for the cancer 
      therapy because of their potent roles on inhibiting inflammation. This study is 
      aimed at performing a safety evaluation and evaluating the role of human 
      umbilical cord mesenchymal stem cells (HUC-MSCs) on tumorigenesis. We found that 
      HUC-MSCs cultured within 20 generations had no significant changes in 
      proliferation, cell cycle, cellular senescence, apoptosis, and expression of 
      mesenchymal stem cell markers. HUC-MSCs were unable to form any tumor in 
      immunodeficiency or normal mice with or without inflammatory stimulation. 
      Intriguingly, we observed that HUC-MSCs inhibited tumorigenesis in B16-derived or 
      AOM/DSS-induced colon cancer models. We reasoned that the effect of HUC-MSCs on 
      tumorigenesis might be through regulating the inflammatory response. Indeed, 
      HUC-MSCs dramatically ameliorated the disease symptoms and pathological changes 
      of DSS-induced colitis mice. We deciphered the mechanism that HUC-MSCs inhibited 
      tumorigenesis through reducing the proportion of macrophages, which were 
      decreased in the mice suffered from AOM/DSS-induced colon cancer. 
      Correspondingly, the expression levels of TNF-alpha and IL-6, which were secreted by 
      macrophages, were significantly decreased in the plasma of colon cancer and 
      colitis mice after injection of HUC-MSCs. This study revealed the role of 
      inhibiting macrophages and shed light on the therapeutic application of HUC-MSCs 
      in inflammation-induced tumorigenesis.
CI  - Copyright (c) 2022 Yanxia Fu et al.
FAU - Fu, Yanxia
AU  - Fu Y
AUID- ORCID: 0000-0002-1590-2619
AD  - Department of Biochemistry and Molecular Biology, Capital Medical University, 
      Beijing 100069, China.
AD  - State Key Laboratory of Membrane Biology, School of Medicine, Institute of 
      Precision Medicine, Tsinghua University, Beijing 100084, China.
FAU - Li, Jun
AU  - Li J
AD  - TsCell Biotech Inc., Beijing 100084, China.
FAU - Li, Mengdi
AU  - Li M
AD  - State Key Laboratory of Membrane Biology, School of Medicine, Institute of 
      Precision Medicine, Tsinghua University, Beijing 100084, China.
FAU - Xu, Junfeng
AU  - Xu J
AD  - Senior Department of Gastroenterology, The First Medical Center of Chinese PLA 
      General Hospital, Beijing 100853, China.
FAU - Rong, Zheng
AU  - Rong Z
AD  - Department of Gynaecology and Obstetrics, Jishuitan Hospital, Beijing 100096, 
      China.
FAU - Ren, Fangli
AU  - Ren F
AD  - State Key Laboratory of Membrane Biology, School of Medicine, Institute of 
      Precision Medicine, Tsinghua University, Beijing 100084, China.
FAU - Wang, Yinyin
AU  - Wang Y
AD  - State Key Laboratory of Membrane Biology, School of Medicine, Institute of 
      Precision Medicine, Tsinghua University, Beijing 100084, China.
FAU - Sheng, Jianqiu
AU  - Sheng J
AUID- ORCID: 0000-0002-9455-0198
AD  - Department of Gastroenterology, The Seventh Medical Center of PLA General 
      Hospital, Beijing 100700, China.
FAU - Chang, Zhijie
AU  - Chang Z
AUID- ORCID: 0000-0003-1567-3227
AD  - State Key Laboratory of Membrane Biology, School of Medicine, Institute of 
      Precision Medicine, Tsinghua University, Beijing 100084, China.
LA  - eng
PT  - Journal Article
DEP - 20220601
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC9178412
COIS- The authors declare that no conflict of interest exists.
EDAT- 2022/06/14 06:00
MHDA- 2022/06/14 06:01
PMCR- 2022/06/01
CRDT- 2022/06/13 03:29
PHST- 2021/10/21 00:00 [received]
PHST- 2022/04/18 00:00 [accepted]
PHST- 2022/06/13 03:29 [entrez]
PHST- 2022/06/14 06:00 [pubmed]
PHST- 2022/06/14 06:01 [medline]
PHST- 2022/06/01 00:00 [pmc-release]
AID - 10.1155/2022/1617229 [doi]
PST - epublish
SO  - Stem Cells Int. 2022 Jun 1;2022:1617229. doi: 10.1155/2022/1617229. eCollection 
      2022.