PMID- 35696100
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220719
IS  - 2224-6614 (Electronic)
IS  - 1021-9498 (Print)
VI  - 28
IP  - 3
DP  - 2020 Sep 15
TI  - Detection of melamine based on the suppressed anodic response of uric acid by a 
      Au-Ag nanoparticles modified glassy carbon electrode.
PG  - 475-485
LID - 10.38212/2224-6614.1075 [doi]
AB  - We demonstrated a sensitive electrochemical method for the determination of 
      nonelectroactive melamine (Mel) using a modified glassy carbon electrode (GCE), 
      with uric acid (UA) as the signal reporter. To increase the anodic response of 
      UA, GCE was coated with Au-Ag nanoparticles and a Nafion thin film 
      (Au-Ag/Nafion/GCE). The sensing mechanism was based on the competitive adsorption 
      behavior of Mel on the Au-Ag/Nafion/GCE, which reduces the electroactive surface 
      area of nanoparticles and thus hinders anodic response of UA. Under optimal 
      conditions and the use of an analytical method of differential pulse voltammetry, 
      this modified electrode detected Mel concentrations ranging from 2.5 to 70 nM, 
      with a detection limit of 1.8 nM. The Au-Ag/Nafion/GCE demonstrated satisfactory 
      reproducibility and stability, with relative standard deviations (RSDs) of 9.3% 
      and 7.1%, respectively. The proposed electrochemical method was then successfully 
      used to determine the Mel content in spiked milk powder and cat food samples, 
      with RSDs of 1.7%-9.3% and recoveries of 92.4%-103.7%.
FAU - Peng, Yu-Hui
AU  - Peng YH
AD  - Department of Chemistry, National Changhua University of Education, 1 Jin-De 
      Road, Changhua City, 50007, Taiwan.
FAU - Wu, Tsunghsueh
AU  - Wu T
AD  - Department of Chemistry, University of Wisconsin-Platteville, 1 University Plaza, 
      Platteville, WI, 53818-3099, USA.
FAU - Lin, Yang-Wei
AU  - Lin YW
AD  - Department of Chemistry, National Changhua University of Education, 1 Jin-De 
      Road, Changhua City, 50007, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20200915
PL  - China (Republic : 1949- )
TA  - J Food Drug Anal
JT  - Journal of food and drug analysis
JID - 101630927
SB  - IM
PMC - PMC9261800
COIS- Conflicts of interest The authors of the manuscript declare that there is no 
      conflict of interest regarding the publication of this study.
EDAT- 2020/09/15 00:00
MHDA- 2020/09/15 00:01
PMCR- 2020/08/28
CRDT- 2022/06/13 11:24
PHST- 2020/05/03 00:00 [received]
PHST- 2020/06/30 00:00 [accepted]
PHST- 2022/06/13 11:24 [entrez]
PHST- 2020/09/15 00:00 [pubmed]
PHST- 2020/09/15 00:01 [medline]
PHST- 2020/08/28 00:00 [pmc-release]
AID - 2224-6614.1075 [pii]
AID - jfda-28-03-475 [pii]
AID - 10.38212/2224-6614.1075 [doi]
PST - epublish
SO  - J Food Drug Anal. 2020 Sep 15;28(3):475-485. doi: 10.38212/2224-6614.1075.