PMID- 35698824
OWN - NLM
STAT- Publisher
LR  - 20240216
IS  - 1122-0643 (Print)
IS  - 1122-0643 (Linking)
DP  - 2022 Jun 10
TI  - Comparison of efficacy of autologous blood patch pleurodesis versus doxycycline 
      pleurodesis in the management of persistent air leak in patients with secondary 
      spontaneous pneumothorax. A randomized control trial.
LID - 10.4081/monaldi.2022.2036 [doi]
AB  - Secondary spontaneous pneumothorax (SSP) patients sometimes have a persistent air 
      leak (PAL) that leads to increased morbidity and increased hospital stay. 
      Further, these patients also need pleurodesis to prevent a recurrence. Autologous 
      blood patch pleurodesis (ABPP) has been successfully tried in post lobectomy air 
      leak cases. However, its utility in SSP patients with PAL has not been widely 
      established. In this context, we performed a non-blinded randomized control study 
      to compare the efficacy of ABPP vs doxycycline pleurodesis in the closure of air 
      leak in SSP patients. This study was a non-blinded randomized control study done 
      in 38 SSP patients with PAL. They were randomized into doxycycline arm and ABPP 
      arm. Post pleurodesis air leak was assessed every 12 hours for cessation. Success 
      was considered when there was a complete cessation of air leak. Post-procedural 
      complications were noted and patients were followed up for 28 days to look for 
      recurrence. The median time for closure was 24 hours [interquartile range 
      (12.24)] for ABPP and 36 hours [interquartile range (24.72)] for doxycycline 
      pleurodesis. Success rate of ABPP vs doxycycline pleurodesis is 94.7% vs 84.2% 
      (p=0.6). Post-procedure pain was more in doxycycline group (15% vs 73%) (p<0.01). 
      On visual analogue scale, ABPP had a lesser pain as compared to doxycycline 
      pleurodesis (average visual analogue scale value of 2 vs scale of 7). The 
      recurrence rate was equal in both groups (5%). Though ABPP and doxycycline have 
      similar success rates, ABPP has an early closure of air leak and greater patient 
      tolerability. ABPP can be tried as an alternative to doxycycline pleurodesis in 
      SSP patients with persistent air leaks.
FAU - Narenchandra, Vijayarangam
AU  - Narenchandra V
AD  - Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical 
      Education and Research (JIPMER), Puducherry. drnaren00@gmail.com.
FAU - Vishnukanth, Govindaraj
AU  - Vishnukanth G
AD  - Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical 
      Education and Research (JIPMER), Puducherry. vishnu1429@yahoo.com.
FAU - Dwivedi, Dharm Prakash
AU  - Dwivedi DP
AD  - Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical 
      Education and Research (JIPMER), Puducherry. dippyd@gmail.com.
FAU - Hemachandren, Munuswamy
AU  - Hemachandren M
AD  - Department of Cardiothoracic and Vascular Surgery, Jawaharlal Institute of 
      Postgraduate Medical Education and Research (JIPMER), Puducherry. 
      mhchandren@gmail.com.
FAU - Adithian, Subathra
AU  - Adithian S
AD  - Department of Radiodiagnosis, Jawaharlal Institute of Postgraduate Medical 
      Education and Research (JIPMER), Puducherry. subathra26@gmail.com.
FAU - Vinod Kumar, Saka
AU  - Vinod Kumar S
AD  - Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical 
      Education and Research (JIPMER), Puducherry. vinoddayamani@hotmail.com.
FAU - Rajangam, Manju
AU  - Rajangam M
AD  - Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical 
      Education and Research (JIPMER), Puducherry. mail2manju22@gmail.com.
FAU - Mohapatra, Madhusmita Mohanty
AU  - Mohapatra MM
AD  - Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical 
      Education and Research (JIPMER), Puducherry. drmadhusmita1@gmail.com.
FAU - Upadhya, Pratap
AU  - Upadhya P
AD  - Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical 
      Education and Research (JIPMER), Puducherry. drpratapu@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220610
PL  - Italy
TA  - Monaldi Arch Chest Dis
JT  - Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
JID - 9307314
SB  - IM
EDAT- 2022/06/15 06:00
MHDA- 2022/06/15 06:00
CRDT- 2022/06/14 03:21
PHST- 2021/07/29 00:00 [received]
PHST- 2022/03/03 00:00 [accepted]
PHST- 2022/06/14 03:21 [entrez]
PHST- 2022/06/15 06:00 [pubmed]
PHST- 2022/06/15 06:00 [medline]
AID - 10.4081/monaldi.2022.2036 [doi]
PST - aheadofprint
SO  - Monaldi Arch Chest Dis. 2022 Jun 10. doi: 10.4081/monaldi.2022.2036.