PMID- 35699203
OWN - NLM
STAT- MEDLINE
DCOM- 20220810
LR  - 20220811
IS  - 1526-9914 (Electronic)
IS  - 1526-9914 (Linking)
VI  - 23
IP  - 8
DP  - 2022 Aug
TI  - The effect of material assignment in nasal cavity on dose calculation for 
      nasopharyngeal carcinoma (NPC) using Acuros XB.
PG  - e13698
LID - 10.1002/acm2.13698 [doi]
LID - e13698
AB  - PURPOSE: To evaluate the effect of material assignment in nasal cavity on dose 
      calculation for the volumetric modulated arc therapy (VMAT) of nasopharyngeal 
      carcinoma (NPC) using Acuros XB (AXB) algorithm. METHODS: The VMAT plans of 30 
      patients with NPC were calculated using AXB with material auto-assignment of 
      nasal cavity to lung and reassignment to air respectively. The doses to the 
      planning target volumes (PTVs) overlapping with nasal cavity with material 
      auto-assignment of lung (AXB_Lung) were compared to the values obtained when 
      nasal cavity was reassigned to air (AXB_Air) under the dose-to-medium (D(m) ) 
      reporting mode of AXB. RESULTS: For dose calculated under AXB_Lung, the D(98%) , 
      D(2%) , and D(mean) of the PTV(69.96) _Air Cavity (PTV of prescription dose 
      69.96 Gy overlapping with nasal cavity) were on average 16.1%, 1.6%, and 8.6% 
      larger than that calculated under AXB_Air, respectively. Up to 19.5% difference 
      in D(98%) , 3% difference in D(2%) , and 11.2% difference in D(mean) were 
      observed in the worst cases for PTV(69.96) . Similar trend was observed for the 
      PTV(5940) _Air Cavity, in which the D(98%) , D(2%) , and D(mean) calculated under 
      AXB_Lung were on average 14.7%, 2.5%, and 10.2% larger than that calculated under 
      AXB_Air, respectively. In the worst cases, the difference observed in D(98%) , 
      D(2%) , and D(mean) could be up to 17.7%, 4.5%, and 12.7%, respectively. 
      CONCLUSIONS: Significant dose difference calculated by AXB between the material 
      assignment of lung and air in nasal cavity for NPC cases might imply the 
      possibility of underdosage to the PTVs that overlap with inhomogeneity. 
      Therefore, attention should be put to ensure that accurate material assignment 
      for dose calculation under AXB such that optimal dosage was given for tumor 
      control.
CI  - (c) 2022 The Authors. Journal of Applied Clinical Medical Physics published by 
      Wiley Periodicals, LLC on behalf of The American Association of Physicists in 
      Medicine.
FAU - Cheung, Michael L M
AU  - Cheung MLM
AD  - Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong SAR, China.
FAU - Chow, Vivian U Y
AU  - Chow VUY
AD  - Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong SAR, China.
FAU - Kan, Monica W K
AU  - Kan MWK
AD  - Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong SAR, China.
AD  - Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong 
      SAR, China.
FAU - Chan, Anthony T C
AU  - Chan ATC
AD  - Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong SAR, China.
AD  - Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong 
      SAR, China.
LA  - eng
PT  - Journal Article
DEP - 20220614
PL  - United States
TA  - J Appl Clin Med Phys
JT  - Journal of applied clinical medical physics
JID - 101089176
SB  - IM
MH  - Algorithms
MH  - Humans
MH  - Nasal Cavity
MH  - Nasopharyngeal Carcinoma/radiotherapy
MH  - *Nasopharyngeal Neoplasms/radiotherapy
MH  - Phantoms, Imaging
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - *Radiotherapy, Intensity-Modulated
PMC - PMC9359034
OTO - NOTNLM
OT  - Acuros XB algorithm
OT  - dose calculation
OT  - inhomogeneity
OT  - material assignment
OT  - nasopharyngeal carcinoma
COIS- The authors declare that there is no conflict of interest that could be perceived 
      as prejudicing the impartiality of the research reported.
EDAT- 2022/06/15 06:00
MHDA- 2022/08/11 06:00
PMCR- 2022/06/14
CRDT- 2022/06/14 06:52
PHST- 2022/04/21 00:00 [revised]
PHST- 2022/02/16 00:00 [received]
PHST- 2022/05/28 00:00 [accepted]
PHST- 2022/06/15 06:00 [pubmed]
PHST- 2022/08/11 06:00 [medline]
PHST- 2022/06/14 06:52 [entrez]
PHST- 2022/06/14 00:00 [pmc-release]
AID - ACM213698 [pii]
AID - 10.1002/acm2.13698 [doi]
PST - ppublish
SO  - J Appl Clin Med Phys. 2022 Aug;23(8):e13698. doi: 10.1002/acm2.13698. Epub 2022 
      Jun 14.