PMID- 35703363 OWN - NLM STAT- MEDLINE DCOM- 20230320 LR - 20230320 IS - 1804-7521 (Electronic) IS - 1213-8118 (Linking) VI - 167 IP - 1 DP - 2023 Mar TI - Complete revascularization of multivessel coronary artery disease in patients with ST elevation acute coronary syndrome - for whom and when? A comprehensive review. PG - 16-23 LID - 10.5507/bp.2022.024 [doi] AB - Atherosclerosis is the most common cause of coronary steno-occlusive disease and acute myocardial infarction is the leading cause of death in industrialized countries. In patients with acute ST elevation myocardial infarction (STEMI), there is unquestionable evidence that primary percutaneous coronary intervention providing recanalization of the infarct related artery (IRA) is the preferred reperfusion strategy. Nevertheless, up to 50% of patients with STEMI have multivessel coronary artery disease defined as at least 50% stenosis exclusive of IRA. There is conflicting data regarding the optimal treatment strategy and timing in such patients. Currently, it is assumed that stable patients might benefit from complete revascularization particularly in reducing the need for future unplanned procedures but only culprit lesion should be treated during index procedure in unstable patients. In this article, we provide a comprehensive overview of this important and currently highly debated topic. FAU - Spacek, Miloslav AU - Spacek M AD - Department of Internal Medicine I - Cardiology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic. FAU - Vacha, Jan AU - Vacha J AD - Department of Internal Medicine I - Cardiology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic. FAU - Precek, Jan AU - Precek J AD - Department of Internal Medicine I - Cardiology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic. FAU - Hutyra, Martin AU - Hutyra M AD - Department of Internal Medicine I - Cardiology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic. FAU - Nykl, Radomir AU - Nykl R AD - Department of Internal Medicine I - Cardiology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic. FAU - Sluka, Martin AU - Sluka M AD - Department of Internal Medicine I - Cardiology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic. FAU - Taborsky, Milos AU - Taborsky M AD - Department of Internal Medicine I - Cardiology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic. LA - eng PT - Journal Article PT - Review DEP - 20220614 PL - Czech Republic TA - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub JT - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia JID - 101140142 SB - IM MH - Humans MH - *Coronary Artery Disease/complications/surgery MH - *ST Elevation Myocardial Infarction/etiology/surgery MH - *Acute Coronary Syndrome/etiology/surgery MH - Treatment Outcome MH - *Myocardial Infarction MH - *Percutaneous Coronary Intervention/adverse effects MH - Arrhythmias, Cardiac OTO - NOTNLM OT - acute ST elevation myocardial infarction (STEMI) OT - atherosclerosis OT - complete revascularization OT - coronary flow OT - fractional flow reserve (FFR) OT - infarct related artery (IRA) OT - multivessel coronary artery disease (CAD) COIS- The authors report no conflicts of interest in this work. EDAT- 2022/06/16 06:00 MHDA- 2023/03/21 06:00 CRDT- 2022/06/15 06:52 PHST- 2022/03/25 00:00 [received] PHST- 2022/05/17 00:00 [accepted] PHST- 2022/06/16 06:00 [pubmed] PHST- 2023/03/21 06:00 [medline] PHST- 2022/06/15 06:52 [entrez] AID - 10.5507/bp.2022.024 [doi] PST - ppublish SO - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023 Mar;167(1):16-23. doi: 10.5507/bp.2022.024. Epub 2022 Jun 14.