PMID- 35705304
OWN - NLM
STAT- MEDLINE
DCOM- 20220802
LR  - 20220831
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 84
IP  - 8
DP  - 2022 Aug 1
TI  - Changes in the expressions of annexin A1, annexin A5, inhibin/activin subunits, 
      and vitamin D receptor mRNAs in pituitary glands of female rats during the 
      estrous cycle: correlation analyses among these factors.
PG  - 1065-1073
LID - 10.1292/jvms.22-0141 [doi]
AB  - Pituitary gonadotropin secretion is regulated by several pituitary factors as 
      well as GnRH and ovarian hormones. To elucidate the regulatory mechanisms of 
      pituitary gonadotropin secretions, we observed changes in the mRNA levels of 
      pituitary factors, namely annexin A1 (Anxa1) and Anxa5, inhibin/activin subunits, 
      follistatin (Fst), and vitamin D receptor (Vdr), in female rat pituitary glands 
      during the estrous cycle. Additionally, levels of LHbeta subunit (Lhb), FSHbeta subunit 
      (Fshb), and GnRH receptor (Gnrh-r) mRNA were examined. During proestrus, Anxa1, 
      Anxa5, Vdr, and inhibin alpha-subunit (Inha) exhibited the lowest levels, while 
      during estrus, activin betaB-subunit (Actbb), Lhb, and Gnrh-r were the lowest. 
      Moreover, Fshb exhibited the highest value during metestrus, whereas Fst did not 
      differ significantly. Correlation analyses revealed 16 statistically significant 
      gene combinations. In particular, four combinations, namely Anxa5 and Inha, Anxa5 
      and Actbb, Inha and Vdr, and Inha and Actbb, were highly significant (P<0.0001), 
      while four combinations, Anxa1 and Anxa5, Anxa1 and Vdr, Anxa5 and Vdr, and Lhb 
      and Gnrh-r, were moderately significant (P<0.001). The remaining eight 
      combinations that exhibited statistical significance were Anxa1 and Inha, Anxa1 
      and Actbb, Vdr and Actbb, Anxa1 and Fshb, Inha and Lhb, Actbb and Fshb, Actbb and 
      Lhb, and Fst and Fshb (P<0.05). These results highlight strong correlations among 
      Anxa1, Anxa5, Vdr, Inha, and Actbb, thereby suggesting that an interaction among 
      ANXA1, ANXA5, and VDR may lead to further communications with inhibin and/or 
      activin in the pituitary gland.
FAU - Murata, Takuya
AU  - Murata T
AD  - Laboratory of Veterinary Physiology, Faculty of Veterinary Medicine, Okayama 
      University of Science, Ehime, Japan.
FAU - Chiba, Shuichi
AU  - Chiba S
AD  - Laboratory of Veterinary Physiology, Faculty of Veterinary Medicine, Okayama 
      University of Science, Ehime, Japan.
FAU - Kawaminami, Mitsumori
AU  - Kawaminami M
AD  - Laboratory of Veterinary Physiology, Faculty of Veterinary Medicine, Okayama 
      University of Science, Ehime, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220615
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Annexin A1)
RN  - 0 (Annexin A5)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Calcitriol)
RN  - 104625-48-1 (Activins)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 57285-09-3 (Inhibins)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
SB  - IM
MH  - *Activins/genetics/metabolism
MH  - Animals
MH  - *Annexin A1/genetics/metabolism
MH  - Annexin A5/metabolism
MH  - Estrous Cycle
MH  - Female
MH  - Follicle Stimulating Hormone
MH  - Gonadotropin-Releasing Hormone
MH  - Inhibins/genetics
MH  - Pituitary Gland/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Receptors, Calcitriol/genetics/metabolism
PMC - PMC9412066
OTO - NOTNLM
OT  - annexin
OT  - estrous cycle
OT  - gonadotropins
OT  - inhibin/activin
OT  - vitamin D receptor
EDAT- 2022/06/16 06:00
MHDA- 2022/08/03 06:00
PMCR- 2022/08/01
CRDT- 2022/06/15 21:23
PHST- 2022/06/16 06:00 [pubmed]
PHST- 2022/08/03 06:00 [medline]
PHST- 2022/06/15 21:23 [entrez]
PHST- 2022/08/01 00:00 [pmc-release]
AID - 22-0141 [pii]
AID - 10.1292/jvms.22-0141 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2022 Aug 1;84(8):1065-1073. doi: 10.1292/jvms.22-0141. Epub 2022 
      Jun 15.