PMID- 35705338
OWN - NLM
STAT- MEDLINE
DCOM- 20220617
LR  - 20220716
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 12
IP  - 6
DP  - 2022 Jun 15
TI  - Features and predictive value of 6-min walk test outcomes in interstitial lung 
      disease: an observation study using wearable monitors.
PG  - e055077
LID - 10.1136/bmjopen-2021-055077 [doi]
LID - e055077
AB  - OBJECTIVES: To describe 6-min walk test (6MWT) outcomes, and to investigate their 
      correlations with cardiopulmonary and lung function among patients with 
      interstitial lung disease (ILD) which was not limited to idiopathic pulmonary 
      fibrosis. METHODS: We collected patients' demographic data and obtained 
      minute-by-minute 6MWT outcomes. Modified Borg scale was employed to assess 
      patients' dyspnoea, whereas New York Heart Association (NYHA) classification and 
      pulmonary function test were used to evaluate patients' cardiopulmonary 
      functions. RESULTS: Heart rate (HR) exhibited a continuous upward trend, while 
      SpO(2) exhibited an overall downward with a slight increase at the fifth minute. 
      The SpO(2) nadir for 70 patients (9.3%) was lower than 80%. Further, the SpO(2) 
      nadir for 78.27% of the participants appeared at the end of the fourth minute. 
      The 6-min walk distance (6MWD) had the strongest correlation with NYHA 
      classification (r=0.82, p<0.01). The ratio of 6MWD to predicted 6MWD was most 
      correlated to forced expiratory volume in the first second (r=0.30, p<0.01) and 
      forced vital capacity (r=0.30, p<0.01). SpO(2) at 3 min had the strongest 
      correlation to patients' diffusing capacity of the lungs for carbon monoxide 
      (r=0.41, p<0.01). We found significant differences in 6MWD (F=2.44, p=0.033), 
      SpO(2) change (F=2.58, p=0.025), HR at 0 min (F=2.87, p=0.014), HR at end of 
      6 min (F=2.58, p=0.025) and HR zenith (F=2.64, p=0.022) between the subtypes of 
      ILD. CONCLUSION: This observation provided an important evidence regarding oxygen 
      titration. It is better to maintain SpO(2) above 88% for 4 min instead of 3 min. 
      SpO(2) at the third minute was the most valuable predictor of patients' lung 
      function. 6MWD and SpO(2) changes were more discriminative in subtypes.
CI  - (c) Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published 
      by BMJ.
FAU - Li, Jiaying
AU  - Li J
AD  - School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 
      Hong Kong, Hong Kong.
FAU - Li, Xiaoyan
AU  - Li X
AD  - Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou 
      Medical College, Guangzhou, Guangdong, China.
FAU - Deng, Miaozhen
AU  - Deng M
AD  - Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou 
      Medical College, Guangzhou, Guangdong, China.
FAU - Liang, Xinyin
AU  - Liang X
AD  - Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou 
      Medical College, Guangzhou, Guangdong, China.
FAU - Wei, Huiqun
AU  - Wei H
AD  - Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou 
      Medical College, Guangzhou, Guangdong, China.
FAU - Wu, Xiaobing
AU  - Wu X
AUID- ORCID: 0000-0003-4644-2325
AD  - Department of Internal Medicine, First Affiliated Hospital of Guangzhou Medical 
      College, Guangzhou, Guangdong, China wuxiaobing_gz@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220615
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Exercise Test
MH  - Exercise Tolerance/physiology
MH  - Humans
MH  - Lung
MH  - *Lung Diseases, Interstitial/diagnosis
MH  - Walk Test
MH  - Walking/physiology
MH  - *Wearable Electronic Devices
PMC - PMC9204441
OTO - NOTNLM
OT  - Interstitial lung disease
OT  - RESPIRATORY MEDICINE (see Thoracic Medicine)
OT  - Rehabilitation medicine
COIS- Competing interests: None declared.
EDAT- 2022/06/16 06:00
MHDA- 2022/06/18 06:00
PMCR- 2022/06/15
CRDT- 2022/06/15 21:41
PHST- 2022/06/15 21:41 [entrez]
PHST- 2022/06/16 06:00 [pubmed]
PHST- 2022/06/18 06:00 [medline]
PHST- 2022/06/15 00:00 [pmc-release]
AID - bmjopen-2021-055077 [pii]
AID - 10.1136/bmjopen-2021-055077 [doi]
PST - epublish
SO  - BMJ Open. 2022 Jun 15;12(6):e055077. doi: 10.1136/bmjopen-2021-055077.