PMID- 35707787
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2699-9404 (Electronic)
IS  - 2699-9404 (Linking)
VI  - 9
IP  - 2
DP  - 2022 Jun
TI  - A Computational Data Mining Strategy to Identify the Common Genetic Markers of 
      Temporomandibular Joint Disorders and Osteoarthritis.
PG  - 159-165
LID - 10.1055/s-0042-1743571 [doi]
AB  - Statement of Problem  Prosthodontic planning in patients with temporomandibular 
      joint disorders (TMDs) is a challenge for the clinicians. Purpose  A differential 
      biomarker identification could aid in developing methods for early detection and 
      confirmation of TMD from other related conditions. Materials and Methods  The 
      present study identified candidate genes with possible association with TMDs. The 
      observational study delineates genes from three datasets retrieved from DisGeNET 
      database. The convergence of datasets identifies potential genes related to TMDs 
      with associated complication such as osteoarthritis. Gene ontology analysis was 
      also performed to identify the potential pathways associated with the genes 
      belonging to each of the datasets. Results  The preliminary analysis revealed 
      vascular endothelial growth factor A ( VEGFA ), interleukin 1 beta ( IL1B , and 
      estrogen receptor 1 ( ESR1 ) as the common genes associated with all three 
      phenotypes assessed. The gene ontology analysis revealed functional pathways in 
      which the genes of each dataset were clustered. The chemokine and cytokine 
      signaling pathway, gonadotropin-releasing hormone receptor pathway, 
      cholecystokinin receptors (CCKR) signaling, and tumor growth factor (TGF)-beta 
      signaling pathway were the pathways most commonly associated with the phenotypes. 
      The genes CCL2, IL6 , and IL1B were found to be the common genes across 
      temporomandibular joint (TMJ) and TMJ + osteoarthritis (TMJ-OA) datasets. 
      Conclusion  Analysis through computational approach has revealed IL1B as the 
      crucial candidate gene which could have a strong association with bone disorders. 
      Nevertheless, several immunological pathways have also identified numerous genes 
      showing putative association with TMJ and other related diseases. These genes 
      have to be further validated using experimental approaches to acquire clarity on 
      the mechanisms related to the pathogenesis.
CI  - The Author(s). This is an open access article published by Thieme under the terms 
      of the Creative Commons Attribution License, permitting unrestricted use, 
      distribution, and reproduction so long as the original work is properly cited. ( 
      https://creativecommons.org/licenses/by/4.0/ ).
FAU - Jayaseelan, Vijayashree Priyadharsini
AU  - Jayaseelan VP
AUID- ORCID: 0000-0001-7884-5466
AD  - Clinical Genetics Lab, Cellular and Molecular Research Centre, Saveetha Dental 
      College and Hospital, Saveetha Institute of Medical and Technical Sciences, 
      Saveetha University, Poonamallee High Road, Chennai, Tamil Nadu, India.
FAU - Arumugam, Paramasivam
AU  - Arumugam P
AUID- ORCID: 0000-0001-6117-1178
AD  - Molecular Biology Lab, Cellular and Molecular Research Centre, Saveetha Dental 
      College and Hospital, Saveetha Institute of Medical and Technical Sciences, 
      Saveetha University, Poonamallee High Road, Chennai, Tamil Nadu, India.
LA  - eng
PT  - Journal Article
DEP - 20220309
PL  - Germany
TA  - Glob Med Genet
JT  - Global medical genetics
JID - 101769583
PMC - PMC9192168
OTO - NOTNLM
OT  - computational approach
OT  - genetic markers
OT  - inflammation
OT  - osteoarthritis
OT  - temporomandibular joint disorders
COIS- Conflict of Interest None declared.
EDAT- 2022/06/17 06:00
MHDA- 2022/06/17 06:01
PMCR- 2022/03/01
CRDT- 2022/06/16 02:45
PHST- 2021/12/27 00:00 [received]
PHST- 2022/01/27 00:00 [accepted]
PHST- 2022/06/16 02:45 [entrez]
PHST- 2022/06/17 06:00 [pubmed]
PHST- 2022/06/17 06:01 [medline]
PHST- 2022/03/01 00:00 [pmc-release]
AID - 2100075 [pii]
AID - 10.1055/s-0042-1743571 [doi]
PST - epublish
SO  - Glob Med Genet. 2022 Mar 9;9(2):159-165. doi: 10.1055/s-0042-1743571. eCollection 
      2022 Jun.