PMID- 35708389
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220724
IS  - 0972-9941 (Print)
IS  - 1998-3921 (Electronic)
IS  - 1998-3921 (Linking)
VI  - 18
IP  - 3
DP  - 2022 Jul-Sep
TI  - Fibrin glue versus autologous platelet-rich fibrin - comparison of effectiveness 
      on the cohort of patients with fistula-in-ano undergoing video-assisted anal 
      fistula treatment.
PG  - 443-449
LID - 10.4103/jmas.jmas_297_21 [doi]
AB  - CONTEXT: Minimally invasive sphincter preserving procedures like ligation of 
      intersphincteric fistula tract (LIFT) and video-assisted anal fistula treatment 
      (VAAFT) are being increasingly used in the treatment of fistula-in-ano. The 
      addition of adjuncts like fibrin glue has improved the results for VAAFT. Our 
      unit has used platelet-rich fibrin (PRF) as an innovative adjunct for VAAFT. 
      AIMS: To compare the effectiveness of two different adjuncts, fibrin glue and 
      autologous PRF, used to fill the treated fistula tracts following VAAFT. SETTINGS 
      AND DESIGN: Retrospective observational study on a cohort of patients undergoing 
      VAAFT at a tertiary centre between 2015 and 2020 comparing two adjuncts used with 
      VAAFT procedure. SUBJECTS AND METHODS: Data of patients who underwent VAAFT for 
      fistula-in-ano were obtained from the hospital database. Group A included 
      patients treated with fibrin as adjunct and PRF as adjunct in Group B. Patients 
      were followed up at 1, 3 and 6 months post-operatively and by a telephonic 
      interview in 2020 to ascertain recent status. All data were entered into an excel 
      sheet. STATISTICAL ANALYSIS USED: Data were analysed using SPSS V20 to test the 
      statistical significance of the difference in the mean healing time between two 
      groups, Mann-Whitney U-test was used and for age, Student's t-test was used. 
      RESULTS: There were 41 patients in Group A and 24 in Group B. There was a 
      significant reduction in recurrence rate in Group B (p = 0.032) and in those 
      patients who had a single internal opening (p = 0.045), single external opening 
      (p = 0.03) and complex tracts (p = 0.033). PRF was cheaper than Fibrin glue. 
      CONCLUSIONS: PRF is more effective and economical with lower recurrence rates.
FAU - Ramachandran, Riju
AU  - Ramachandran R
AD  - Department of General Surgery, Amrita Institute of Medical Sciences, Kochi, 
      Kerala, India.
FAU - Gunasekharan, Vaishnavi
AU  - Gunasekharan V
AD  - Department of General Surgery, Amrita Institute of Medical Sciences, Kochi, 
      Kerala, India.
FAU - Pillai, Anoop Vasudevan
AU  - Pillai AV
AD  - Department of General Surgery, Amrita Institute of Medical Sciences, Kochi, 
      Kerala, India.
FAU - Raja, Suyambu
AU  - Raja S
AD  - Department of General Surgery, Amrita Institute of Medical Sciences, Kochi, 
      Kerala, India.
FAU - Nair, Anjaly S
AU  - Nair AS
AD  - Department of Biostatistics, Amrita Institute of Medical Sciences, Kochi, Kerala, 
      India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Minim Access Surg
JT  - Journal of minimal access surgery
JID - 101228183
PMC - PMC9306109
OTO - NOTNLM
OT  - Fistula
OT  - operative procedure
OT  - platelet-rich fibrin
OT  - video-assisted anal fistula treatment
COIS- None
EDAT- 2022/06/17 06:00
MHDA- 2022/06/17 06:01
PMCR- 2022/07/01
CRDT- 2022/06/16 09:31
PHST- 2022/06/16 09:31 [entrez]
PHST- 2022/06/17 06:00 [pubmed]
PHST- 2022/06/17 06:01 [medline]
PHST- 2022/07/01 00:00 [pmc-release]
AID - JMinAccessSurg_2022_18_3_443_336265 [pii]
AID - JMAS-18-443 [pii]
AID - 10.4103/jmas.jmas_297_21 [doi]
PST - ppublish
SO  - J Minim Access Surg. 2022 Jul-Sep;18(3):443-449. doi: 10.4103/jmas.jmas_297_21.