PMID- 35708634
OWN - NLM
STAT- MEDLINE
DCOM- 20220620
LR  - 20220623
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 25
IP  - 6
DP  - 2022 Jun
TI  - Alcohol Drinks Induce Acute Lowering in Circulating l-Arginine in Obese and Type 
      2 Diabetic Subjects.
PG  - 675-682
LID - 10.1089/jmf.2021.0045 [doi]
AB  - Since low serum l-arginine (Arg) and high asymmetric dimethylarginine (ADMA) can 
      predict microvascular complications in type 2 diabetes mellitus (T2DM), we tested 
      whether Arg and ADMA are affected by diet and physical activity in 
      overweight/obese and T2DM subjects. We tested the effects on serum Arg and ADMA 
      of single loads of dextrose, protein, fat, or alcohol ( approximately 300 calories each); one 
      episode of physical exercise; and 12 weeks of standard lifestyle modification 
      (dietary and physical activity counseling). Alcohol drink was followed by  approximately 30% 
      lowering in Arg. Arg and ADMA increased after a protein load but remained stable 
      after glucose or fat load or 30 min of treadmill walk. Following 12 weeks of 
      lifestyle modification, ADMA declined only in subjects achieving weight loss >5%. 
      In conclusion, alcohol is a previously unrecognized acute suppressor of serum 
      Arg. Lifestyle modification lowers ADMA in subjects who achieve weight loss >5%. 
      Clinical Trial Registration Number: NCT04406402.
FAU - Buch, Assaf
AU  - Buch A
AUID- ORCID: 0000-0002-4412-6532
AD  - The Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky 
      Medical Center.
AD  - The Sagol Center for Epigenetics of Metabolism and Aging, The Institute of 
      Endocrinology, Metabolism and Hypertension; Tel Aviv Sourasky Medical Center, Tel 
      Aviv, Israel.
FAU - Ganz, Tali
AU  - Ganz T
AD  - Diabetes Unit, E. Wolfson Medical Center, Holon, Israel.
FAU - Wainstein, Julio
AU  - Wainstein J
AD  - Diabetes Unit, E. Wolfson Medical Center, Holon, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Gilad, Suzan
AU  - Gilad S
AD  - The Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky 
      Medical Center.
FAU - Limor, Rona
AU  - Limor R
AD  - The Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky 
      Medical Center.
FAU - Shefer, Gabi
AU  - Shefer G
AD  - The Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky 
      Medical Center.
AD  - The Sagol Center for Epigenetics of Metabolism and Aging, The Institute of 
      Endocrinology, Metabolism and Hypertension; Tel Aviv Sourasky Medical Center, Tel 
      Aviv, Israel.
FAU - Boaz, Mona
AU  - Boaz M
AUID- ORCID: 0000-0002-3920-7549
AD  - Department of Nutrition Sciences, Ariel University, Ariel, Israel.
FAU - Stern, Naftali
AU  - Stern N
AUID- ORCID: 0000-0002-5123-3176
AD  - The Sagol Center for Epigenetics of Metabolism and Aging, The Institute of 
      Endocrinology, Metabolism and Hypertension; Tel Aviv Sourasky Medical Center, Tel 
      Aviv, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
LA  - eng
SI  - ClinicalTrials.gov/NCT04406402
PT  - Journal Article
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - *Alcohol Drinking
MH  - *Arginine/blood
MH  - *Diabetes Mellitus, Type 2
MH  - Humans
MH  - Obesity/blood
MH  - Overweight
MH  - Weight Loss
OTO - NOTNLM
OT  - arginine
OT  - asymmetric dimethylarginine
OT  - diabetes mellitus
OT  - metabolic syndrome
OT  - obesity
EDAT- 2022/06/17 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/06/16 11:17
PHST- 2022/06/16 11:17 [entrez]
PHST- 2022/06/17 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
AID - 10.1089/jmf.2021.0045 [doi]
PST - ppublish
SO  - J Med Food. 2022 Jun;25(6):675-682. doi: 10.1089/jmf.2021.0045.