PMID- 35708733
OWN - NLM
STAT- MEDLINE
DCOM- 20220822
LR  - 20221007
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 107
IP  - 9
DP  - 2022 Aug 18
TI  - Impaired Sensitivity to Thyroid Hormones Is Associated With Elevated Homocysteine 
      Levels in the Euthyroid Population.
PG  - e3731-e3737
LID - 10.1210/clinem/dgac371 [doi]
AB  - CONTEXT: Homocysteine (Hcy), a known risk factor for cardiovascular disease, has 
      been reported to be linked with thyroid dysfunction. However, the association of 
      thyroid hormones sensitivity with Hcy levels remains unknown. OBJECTIVE: We aimed 
      to investigate the relationship between thyroid hormone sensitivity and elevated 
      Hcy levels in the euthyroid population. METHODS: A total of 8957 euthyroid adults 
      were included in this study. Free triiodothyronine (FT3), free thyroxine (FT4), 
      thyrotropin (TSH), Hcy levels, and other clinical parameters were measured. 
      Hyperhomocysteinemia (HHcy) was defined as serum Hcy level > 15 mumol/L. Thyroid 
      hormone sensitivity indices were calculated by thyroid feedback quantile-based 
      index (TFQI), Chinese-referenced parametric TFQI (PTFQI), TSH index (TSHI) and 
      thyrotropin thyroxine resistance index (TT4RI). RESULTS: Subjects with decreased 
      sensitivity to thyroid hormones had higher Hcy levels (P for trend < 0.001). 
      Logistic regression analysis revealed the higher quartiles of TFQI, PTFQI, TSHI, 
      and TT4RI were significantly associated with elevated Hcy levels, and these 
      associations remained significant even after adjustment for multiple risk 
      factors. After adjusting for age, sex, body mass index, dyslipidemia, fatty 
      liver, diabetes, and hypertension, the odds ratio (95% CI) for having HHcy of the 
      TFQI in the highest quartile was 1.393 (1.210, 1.603), the PTFQI in the highest 
      quartile was 1.409 (1.225, 1.621), the TSHI in the highest quartile was 1.372 
      (1.190, 1.583), and the TT4RI in the highest quartile was 1.315 (1.141, 1.515) 
      (all P < 0.001). CONCLUSION: In euthyroid subjects, impaired sensitivity to 
      thyroid hormones was associated with elevated Hcy levels.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Ding, Xiaoyu
AU  - Ding X
AD  - Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical 
      University, Beijing 100020, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Physical Examination Center, Beijing Chao-yang Hospital, Capital Medical 
      University, Beijing 100020, China.
FAU - Liu, Jia
AU  - Liu J
AUID- ORCID: 0000-0002-6957-3814
AD  - Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical 
      University, Beijing 100020, China.
FAU - Wang, Guang
AU  - Wang G
AUID- ORCID: 0000-0001-9321-5200
AD  - Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical 
      University, Beijing 100020, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Receptors, Thyrotropin)
RN  - 0 (Thyroid Hormones)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
RN  - Hypothyroidism, Congenital, Nongoitrous, 1
RN  - Hypothyroidism, Congenital, Nongoitrous, 3
SB  - IM
MH  - Adult
MH  - Congenital Hypothyroidism
MH  - Homocysteine
MH  - Humans
MH  - Receptors, Thyrotropin/deficiency
MH  - Thyroid Function Tests
MH  - *Thyroid Hormone Resistance Syndrome
MH  - Thyroid Hormones
MH  - Thyrotropin
MH  - *Thyroxine
MH  - Triiodothyronine
OTO - NOTNLM
OT  - cardiovascular disease risk
OT  - euthyroid
OT  - homocysteine
OT  - sensitivity to thyroid hormones
EDAT- 2022/06/17 06:00
MHDA- 2022/08/23 06:00
CRDT- 2022/06/16 11:43
PHST- 2022/03/09 00:00 [received]
PHST- 2022/06/17 06:00 [pubmed]
PHST- 2022/08/23 06:00 [medline]
PHST- 2022/06/16 11:43 [entrez]
AID - 6609259 [pii]
AID - 10.1210/clinem/dgac371 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2022 Aug 18;107(9):e3731-e3737. doi: 
      10.1210/clinem/dgac371.