PMID- 35710012 OWN - NLM STAT- MEDLINE DCOM- 20220628 LR - 20220628 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 840 DP - 2022 Sep 20 TI - Fate and toxicity of legacy and novel brominated flame retardants in a sediment-water-clam system: Bioaccumulation, elimination, biotransformation and structural damage. PG - 156634 LID - S0048-9697(22)03731-7 [pii] LID - 10.1016/j.scitotenv.2022.156634 [doi] AB - Due to the characteristics of persistent organic pollutants (POPs), some legacy brominated flame retardants (LBFRs) were prohibited from use, and then gradually replaced by novel brominated flame retardants (NBFRs). However, till now little research focused on the effects of NBFRs on the benthos. In the present study, 0.5, 5, and 50 mg/kg dw of pentabromotoluene (PBT), hexabromobenzene (HBB), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), decabromodiphenyl ethane (DBDPE) and decabromodiphenyl ether (BDE209) were added into sediments to test freshwater clams (Corbicula fluminea). In the 35-day exposure experiment, C. fluminea had different enrichment behaviors in three treatment groups. It was conjectured that in the lower dose group, the clams ingested contaminants and tended to be stable over time. While in higher dose groups, the clams were induced by the chemicals, leading to the changes in physiological activities so that the concentrations showed a downward trend first and then went up. The half-lives of contaminants in freshwater clams were between 0.911 and 11.6 days. DBDPE showed stronger bioaccumulation ability than BDE209 in this study. Parabolic relationships were observed between log BSAF and log K(ow) values in clam tissues. Debromination, hydroxylation, and methoxylated products were detected. Additionally, the gill samples of C. fluminea exposed to 50 mg/kg dw of single substance were observed by scanning electron microscope (SEM), indicating that the adhesions, tissue hyperplasia, and messy cilia occurred on the surface. Our research potentially contributes to further evaluations of the environmental risks posed in sediments contaminated by PBT, HBB, BTBPE, DBDPE, and BDE209, particularly the benthic organisms. CI - Copyright (c) 2022 Elsevier B.V. All rights reserved. FAU - Zhou, Shanqi AU - Zhou S AD - State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China. FAU - Fu, Mengru AU - Fu M AD - State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China. FAU - Luo, Kailun AU - Luo K AD - State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China. FAU - Qiao, Zhihua AU - Qiao Z AD - State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China. FAU - Peng, Cheng AU - Peng C AD - State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China. FAU - Zhang, Wei AU - Zhang W AD - State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address: wzhang@ecust.edu.cn. FAU - Lei, Juying AU - Lei J AD - State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China. FAU - Ling, Siyuan AU - Ling S AD - State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, Shanghai Academy of Environmental Sciences, Shanghai 200233, China. Electronic address: lingsy@saes.sh.cn. FAU - Zhou, Bingsheng AU - Zhou B AD - State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China. LA - eng PT - Journal Article DEP - 20220614 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Flame Retardants) RN - 0 (Halogenated Diphenyl Ethers) RN - 059QF0KO0R (Water) SB - IM MH - Animals MH - Bioaccumulation MH - Biotransformation MH - *Bivalvia MH - Environmental Monitoring MH - *Flame Retardants/analysis MH - Halogenated Diphenyl Ethers/analysis MH - Water OTO - NOTNLM OT - BDE209 OT - Bioaccumulation OT - Biotransformation OT - C. fluminea OT - NBFRs COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/06/17 06:00 MHDA- 2022/06/29 06:00 CRDT- 2022/06/16 19:33 PHST- 2022/03/16 00:00 [received] PHST- 2022/06/07 00:00 [revised] PHST- 2022/06/07 00:00 [accepted] PHST- 2022/06/17 06:00 [pubmed] PHST- 2022/06/29 06:00 [medline] PHST- 2022/06/16 19:33 [entrez] AID - S0048-9697(22)03731-7 [pii] AID - 10.1016/j.scitotenv.2022.156634 [doi] PST - ppublish SO - Sci Total Environ. 2022 Sep 20;840:156634. doi: 10.1016/j.scitotenv.2022.156634. Epub 2022 Jun 14.