PMID- 35712847
OWN - NLM
STAT- MEDLINE
DCOM- 20220715
LR  - 20220716
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 36
IP  - 7
DP  - 2022 Jul
TI  - Prevalence and correlative factors of hyperhomocysteinemia in elderly patients 
      with femoral neck fracture: A cross-sectional study.
PG  - e24563
LID - 10.1002/jcla.24563 [doi]
LID - e24563
AB  - AIMS: The occurrence of hyperhomocysteinemia (HHcy) in elderly patients with 
      femoral neck fracture (FNF) draws little attention from surgeons preoperatively. 
      The aim of our study was to determine the prevalence and correlative factors of 
      HHcy in elderly patients (>/=65 years) with FNF prior to surgery. METHODS: We 
      retrospectively investigated 286 elderly FNF patients aged 65-98 years admitted 
      to our institution from September 2020 to September 2021. Categorical variables 
      were compared using the Chi-squared test, and continuous variables were compared 
      using the Mann-Whitney U test. Univariable and multivariable logistic regression 
      were used to determine the associations of variables with the odds of HHcy. 
      RESULTS: Among the 286 elderly FNF patients, the prevalence of HHcy was 30.77% 
      and the mean Hcy level was 14.52 +/- 10.49 mumol/L. The mean Hcy level and the 
      prevalence of HHcy in male patients were significantly higher than that in female 
      patients (16.41 +/- 9.58 mumol/L vs. 14.00 +/- 10.69 mumol/L, p = 0.002; 43.55% vs. 
      27.23%, p = 0.014). Multivariate analysis indicated that being male patient (OR 
      2.187, 95% CI 1.187-4.028, p = 0.012), hypertension (OR 1.993, 95% CI 
      1.141-3.479, p = 0.015), and low HDL-C (OR 2.979, 95% CI 1.353-6.558, p = 0.007) 
      were significant correlative factors of HHcy among elderly FNF patients. 
      CONCLUSIONS: This study found a high prevalence of HHcy in elderly FNF patients, 
      with being male patient, hypertension, and low levels of HDL-C as the significant 
      correlative factors after adjusting for age and other covariables. However, 
      further large-scale studies in wider regions are warranted to confirm these 
      findings.
CI  - (c) 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley 
      Periodicals LLC.
FAU - Tao, Kun
AU  - Tao K
AD  - Department of Orthopedic Surgery, Ningbo No.6 Hospital, Ningbo City, China.
FAU - Li, Ming
AU  - Li M
AD  - Department of Orthopedic Surgery, Ningbo No.6 Hospital, Ningbo City, China.
FAU - Ling, Jing
AU  - Ling J
AD  - Department of Orthopedic Surgery, Ningbo No.6 Hospital, Ningbo City, China.
FAU - Tu, Yiji
AU  - Tu Y
AUID- ORCID: 0000-0002-5468-4386
AD  - Department of Orthopedic Surgery, Ningbo No.6 Hospital, Ningbo City, China.
LA  - eng
PT  - Journal Article
DEP - 20220617
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Femoral Neck Fractures/complications/epidemiology
MH  - Homocysteine
MH  - Humans
MH  - *Hyperhomocysteinemia/complications/epidemiology
MH  - *Hypertension/epidemiology
MH  - Male
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC9279943
OTO - NOTNLM
OT  - elderly
OT  - femoral neck fracture
OT  - homocysteine
OT  - regression model
COIS- The authors declare no conflicts of interest.
EDAT- 2022/06/18 06:00
MHDA- 2022/07/16 06:00
PMCR- 2022/06/17
CRDT- 2022/06/17 03:14
PHST- 2022/06/04 00:00 [revised]
PHST- 2022/04/13 00:00 [received]
PHST- 2022/06/06 00:00 [accepted]
PHST- 2022/06/18 06:00 [pubmed]
PHST- 2022/07/16 06:00 [medline]
PHST- 2022/06/17 03:14 [entrez]
PHST- 2022/06/17 00:00 [pmc-release]
AID - JCLA24563 [pii]
AID - 10.1002/jcla.24563 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2022 Jul;36(7):e24563. doi: 10.1002/jcla.24563. Epub 2022 Jun 
      17.