PMID- 35713781
OWN - NLM
STAT- MEDLINE
DCOM- 20221215
LR  - 20221220
IS  - 2190-3948 (Electronic)
IS  - 2190-393X (Linking)
VI  - 13
IP  - 1
DP  - 2023 Jan
TI  - Advanced triboelectric nanogenerator-driven drug delivery systems for targeted 
      therapies.
PG  - 54-78
LID - 10.1007/s13346-022-01184-9 [doi]
AB  - In the current decade, remarkable efforts have been made to develop a 
      self-regulated, on-demand and controlled release drug delivery system driven by 
      triboelectric nanogenerators (TENGs). TENGs have great potential to convert 
      biomechanical energy into electricity and are suitable candidates for 
      self-powered drug delivery systems (DDSs) with exciting features such as small 
      size, easy fabrication, biocompatible, high power output and economical. This 
      review exclusively explains the development and implementation process of 
      TENG-mediated, self-regulated, on-demand and targeted DDSs. It also highlights 
      the recently used TENG-driven DDSs for cancer therapy, infected wounds healing, 
      tissue regeneration and many other chronic disorders. Moreover, it summarises the 
      crucial challenges that are needed to be addressed for their universal 
      applications. Finally, a roadmap to advance the TENG-based drug delivery system 
      developments is depicted for the targeted therapies and personalised healthcare.
CI  - (c) 2022. Controlled Release Society.
FAU - Ikram, Muhammad
AU  - Ikram M
AD  - Dr. Panjwani Center for Molecular Medicine and Drug Research, International 
      Center for Chemical and Biological Sciences, University of Karachi, 
      Karachi-75270, Pakistan.
FAU - Mahmud, M A Parvez
AU  - Mahmud MAP
AUID- ORCID: 0000-0002-1905-6800
AD  - School of Engineering, Deakin University, Geelong, VIC, 3216, Australia. 
      m.a.mahmud@deakin.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220617
PL  - United States
TA  - Drug Deliv Transl Res
JT  - Drug delivery and translational research
JID - 101540061
SB  - IM
MH  - Humans
MH  - *Drug Delivery Systems
MH  - Wound Healing
MH  - *Wound Infection
OTO - NOTNLM
OT  - Controlled drug release
OT  - Drug delivery
OT  - Targeted therapies
OT  - Triboelectric nanogenerators
EDAT- 2022/06/18 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/06/17 11:19
PHST- 2022/05/12 00:00 [accepted]
PHST- 2022/06/18 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/06/17 11:19 [entrez]
AID - 10.1007/s13346-022-01184-9 [pii]
AID - 10.1007/s13346-022-01184-9 [doi]
PST - ppublish
SO  - Drug Deliv Transl Res. 2023 Jan;13(1):54-78. doi: 10.1007/s13346-022-01184-9. 
      Epub 2022 Jun 17.