PMID- 35713788
OWN - NLM
STAT- MEDLINE
DCOM- 20221111
LR  - 20221111
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 45
IP  - 6
DP  - 2022 Dec
TI  - Inhibitory Effects of Cold Atmospheric Plasma on Inflammation and Tumor-Like 
      Feature of Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis.
PG  - 2433-2448
LID - 10.1007/s10753-022-01703-3 [doi]
AB  - Rheumatoid arthritis (RA) is a chronic, debilitating systemic disease 
      characterized by chronic inflammation and progressive joint destruction. 
      Fibroblast-like synoviocytes (FLSs) are one of the most important players in the 
      pathophysiology of RA, acting like tumor cells and secreting inflammatory 
      cytokines. Previous research has shown that cold atmospheric plasma (CAP) 
      inhibits cancer cells and may have anti-inflammatory properties. This study 
      examined the effects of argon plasma jet-produced CAP on the suppression of 
      invasion and inflammation caused by cultured RA-FLS. The findings revealed that 
      CAP reduced cell viability and elevated the percentage of apoptotic RA-FLS by 
      producing reactive oxygen species. Carboxyfluorescein diacetate succinimidyl 
      ester (CFSE) staining confirmed that CAP could decrease the proliferation of 
      RA-FLS. Furthermore, CAP effectively reduced the production of inflammatory 
      factors (e.g., NF-kappaB and IL-6) as well as destructive factors like receptor 
      activator of nuclear factor kappa-B ligand (RANKL) and matrix 
      metalloproteinases-3 (MMP-3). These data suggest that CAP could be a promising 
      treatment for slowing the progression of RA by reducing tumor-like features and 
      inflammation in RA-FLS.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Faramarzi, Fatemeh
AU  - Faramarzi F
AD  - Department of Immunology, Faculty of Medicine, Mazandaran University of Medical 
      Science, Sari, Iran.
FAU - Zafari, Parisa
AU  - Zafari P
AD  - Department of Immunology, Faculty of Medicine, Mazandaran University of Medical 
      Science, Sari, Iran.
FAU - Alimohammadi, Mina
AU  - Alimohammadi M
AD  - Department of Immunology, Faculty of Medicine, Shahid Beheshti University of 
      Medical Science, Tehran, Iran.
FAU - Golpour, Monireh
AU  - Golpour M
AD  - Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran 
      University of Medical Science, Sari, Iran.
FAU - Ghaffari, Salman
AU  - Ghaffari S
AD  - Mazandaran University of Medical Sciences, Orthopedic Research Center, Sari, 
      Iran.
FAU - Rafiei, Alireza
AU  - Rafiei A
AUID- ORCID: 0000-0002-1766-6605
AD  - Department of Immunology, Faculty of Medicine, Mazandaran University of Medical 
      Science, Sari, Iran. rafiei1710@gmail.com.
LA  - eng
GR  - MAZUMS/Mazandaran University of Medical Sciences/
GR  - IR.MAZUMS.REC.1398.6891/Mazandaran University of Medical Sciences/
PT  - Journal Article
DEP - 20220617
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Plasma Gases)
RN  - 0 (NF-kappa B)
SB  - IM
MH  - Humans
MH  - *Synoviocytes/pathology
MH  - *Plasma Gases/pharmacology/therapeutic use
MH  - *Arthritis, Rheumatoid/pathology
MH  - Fibroblasts/pathology
MH  - NF-kappa B
MH  - Inflammation/pathology
MH  - Cells, Cultured
MH  - Cell Proliferation
OTO - NOTNLM
OT  - MMP-3
OT  - RANKL.
OT  - apoptosis
OT  - cold atmospheric plasma
OT  - fibroblast-like synoviocytes
OT  - inflammation
EDAT- 2022/06/18 06:00
MHDA- 2022/11/15 06:00
CRDT- 2022/06/17 11:19
PHST- 2022/04/04 00:00 [received]
PHST- 2022/06/07 00:00 [accepted]
PHST- 2022/06/03 00:00 [revised]
PHST- 2022/06/18 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/06/17 11:19 [entrez]
AID - 10.1007/s10753-022-01703-3 [pii]
AID - 10.1007/s10753-022-01703-3 [doi]
PST - ppublish
SO  - Inflammation. 2022 Dec;45(6):2433-2448. doi: 10.1007/s10753-022-01703-3. Epub 
      2022 Jun 17.