PMID- 35714552 OWN - NLM STAT- MEDLINE DCOM- 20220726 LR - 20220913 IS - 1879-1379 (Electronic) IS - 0022-3956 (Linking) VI - 152 DP - 2022 Aug TI - The role of mixed B vitamin intakes on cognitive performance: Modeling, genes and miRNAs involved. PG - 38-56 LID - S0022-3956(22)00303-X [pii] LID - 10.1016/j.jpsychires.2022.06.006 [doi] AB - OBJECTIVE: To assess the relationships between mixed B vitamin intakes (B1, B2, B3, B6, B9, B12) and cognitive performance, as well as their molecular mechanisms. METHODS: The associations of mixed B vitamin intakes with cognitive function were assessed using multivariate regression models, weighted quantile sum (WQS), quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR). GeneMANIA, Comparative Toxicogenomics Database, MIENTURNET, miRNAsong were employed as the main data-mining methods. RESULTS: Overall effects of the B vitamin intake mixture were significantly associated with global cognition in the WQS, qgcomp, and BKMR models. A mixture of B vitamins (B1, B2, B3, B9) interacted with the five genes (IL1B, BCL2, CASP3, BAX, PTGS2) and was associated with better cognitive function, especially CASP3 and BAX. Physical interactions (77.6%) were observed to be the most important interactions in gene networks. The IL-18 signaling pathway, apoptosis, and Alzheimer's disease were annotated as the key molecular mechanisms involved in mixed B vitamins' improving cognitive function. NFKB1, ATF3, and NR3C1 were the key significant transcription factors associated with cognitive function targeted by a mixture of B vitamins. The strong interaction and expression of hsa-miR-34a-5p, hsa-miR-128-3p, hsa-miR-181a-5p, and hsa-miR-204-5p are involved in mixed B vitamins' better cognitive performance. We also created and evaluated miRNA sponge sequences for these miRNAs, which might be used to alleviate cognitive decline. The cutoff thresholds for B vitamin intake levels that are associated with cognition performance were reported. CONCLUSIONS: Given the increased incidence of dementia across the world, increasing daily mixed B vitamin intake via regular meals may contribute to minimizing dementia risk. Further studies are warranted to identify these links in well-characterized cohorts of diverse populations, either independently or together. CI - Copyright (c) 2022 Elsevier Ltd. All rights reserved. FAU - Nguyen, Hai Duc AU - Nguyen HD AD - Department of Pharmacy, College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, 57922, Republic of Korea. Electronic address: duchainguyen1706@gmail.com. FAU - Kim, Min-Sun AU - Kim MS AD - Department of Pharmacy, College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, 57922, Republic of Korea. Electronic address: minsun@scnu.ac.kr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220609 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 RN - 0 (MIRN204 microRNA, human) RN - 0 (MicroRNAs) RN - 0 (bcl-2-Associated X Protein) RN - 12001-76-2 (Vitamin B Complex) RN - EC 3.4.22.- (Caspase 3) RN - P6YC3EG204 (Vitamin B 12) SB - IM MH - *Alzheimer Disease MH - Bayes Theorem MH - Caspase 3/pharmacology MH - Cognition MH - Humans MH - *MicroRNAs/genetics MH - Vitamin B 12/pharmacology MH - *Vitamin B Complex/pharmacology MH - bcl-2-Associated X Protein OTO - NOTNLM OT - Alzheimer's disease OT - B vitamin intake OT - Cognitive function OT - Modeling OT - Molecular mechanisms EDAT- 2022/06/18 06:00 MHDA- 2022/07/27 06:00 CRDT- 2022/06/17 18:23 PHST- 2022/03/26 00:00 [received] PHST- 2022/05/29 00:00 [revised] PHST- 2022/06/06 00:00 [accepted] PHST- 2022/06/18 06:00 [pubmed] PHST- 2022/07/27 06:00 [medline] PHST- 2022/06/17 18:23 [entrez] AID - S0022-3956(22)00303-X [pii] AID - 10.1016/j.jpsychires.2022.06.006 [doi] PST - ppublish SO - J Psychiatr Res. 2022 Aug;152:38-56. doi: 10.1016/j.jpsychires.2022.06.006. Epub 2022 Jun 9.