PMID- 35715925
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20220621
IS  - 1550-7033 (Print)
IS  - 1550-7033 (Linking)
VI  - 18
IP  - 3
DP  - 2022 Mar 1
TI  - Recent Advances of Human Leukocyte Antigen (HLA) Typing Technology Based on 
      High-Throughput Sequencing.
PG  - 617-639
LID - 10.1166/jbn.2022.3280 [doi]
AB  - The major histocompatibility complex (MHC) in humans is a genetic region 
      consisting of cell surface proteins located on the short arm of chromosome 6. 
      This is also known as the human leukocyte antigen (HLA) region. The HLA region 
      consists of genes that exhibit complex genetic polymorphisms, and are extensively 
      involved in immune responses. Each individual has a unique set of HLAs. 
      Donor-recipient HLA allele matching is an important factor for organ 
      transplantation. Therefore, an established rapid and accurate HLA typing 
      technology is instrumental to preventing graft-verses-host disease (GVHD) in 
      organ recipients. As of recent, high-throughput sequencing has allowed for an 
      increase read length and higher accuracy and throughput, thus achieving complete 
      and high-resolution full-length typing. With more advanced nanotechnology used in 
      high-throughput sequencing, HLA typing is more widely used in third-generation 
      single-molecule sequencing. This review article summarizes some of the most 
      widely used sequencing typing platforms and evaluates the latest developments in 
      HLA typing kits and their clinical applications.
FAU - Yang, Jin
AU  - Yang J
AD  - Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of 
      Technology, Zhuzhou 412007, Hunan, China.
FAU - Liu, Hongna
AU  - Liu H
AD  - Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of 
      Technology, Zhuzhou 412007, Hunan, China.
FAU - Pan, Wenjing
AU  - Pan W
AD  - Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of 
      Technology, Zhuzhou 412007, Hunan, China.
FAU - Song, Mengru
AU  - Song M
AD  - Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of 
      Technology, Zhuzhou 412007, Hunan, China.
FAU - Lu, Yutong
AU  - Lu Y
AD  - School of Electrical and Information Engineering, Hunan University, Changsha 
      410012, Hunan, China.
FAU - Wang-Ngai Chow, Franklin
AU  - Wang-Ngai Chow F
AD  - Department of Health Technology and Informatics, The Hong Kong Polytechnic 
      University, Hong Kong 999077, China.
FAU - Hang-Mei Leung, Polly
AU  - Hang-Mei Leung P
AD  - Department of Health Technology and Informatics, The Hong Kong Polytechnic 
      University, Hong Kong 999077, China.
FAU - Deng, Yan
AU  - Deng Y
AD  - Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of 
      Technology, Zhuzhou 412007, Hunan, China.
FAU - Hori, Masahi
AU  - Hori M
AD  - 2-16-5 Edagawa, Koto-Ku, Tokyo, 135-0051, Japan.
FAU - He, Nongyue
AU  - He N
AD  - Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of 
      Technology, Zhuzhou 412007, Hunan, China.
FAU - Li, Song
AU  - Li S
AD  - Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of 
      Technology, Zhuzhou 412007, Hunan, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Biomed Nanotechnol
JT  - Journal of biomedical nanotechnology
JID - 101230869
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - *HLA Antigens/genetics
MH  - *High-Throughput Nucleotide Sequencing
MH  - Histocompatibility Testing
MH  - Humans
MH  - Technology
EDAT- 2022/06/19 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/06/18 00:42
PHST- 2022/06/18 00:42 [entrez]
PHST- 2022/06/19 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
AID - 10.1166/jbn.2022.3280 [doi]
PST - ppublish
SO  - J Biomed Nanotechnol. 2022 Mar 1;18(3):617-639. doi: 10.1166/jbn.2022.3280.