PMID- 35716046
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20230521
IS  - 1468-2834 (Electronic)
IS  - 0002-0729 (Linking)
VI  - 51
IP  - 6
DP  - 2022 Jun 1
TI  - Association of statin pretreatment with presentation characteristics, infarct 
      size and outcome in older patients with acute coronary syndrome: the Elderly 
      ACS-2 trial.
LID - afac121 [pii]
LID - 10.1093/ageing/afac121 [doi]
AB  - BACKGROUND: prior statin treatment has been shown to have favourable effects on 
      short- and long-term prognosis in patients with acute coronary syndrome (ACS). 
      There are limited data in older patients. The aim of this study was to 
      investigate the association of previous statin therapy and presentation 
      characteristics, infarct size and clinical outcome in older patients, with or 
      without atherosclerotic cardiovascular disease (ASCVD), included in the 
      Elderly-ACS 2 trial. METHODS: data on statin use pre-admission were available for 
      1,192 of the 1,443 patients enrolled in the original trial. Of these, 531 (44.5%) 
      were already taking statins. Patients were stratified based on established ASCVD 
      and statin therapy. ACS was classified as non-ST elevation or ST elevation 
      myocardial infarction (STEMI). Infarct size was measured by peak creatine kinase 
      MB (CK-MB). All-cause death in-hospital and within 1 year were the major end 
      points. RESULTS: there was a significantly lower frequency of STEMI in statin 
      patients, in both ASCVD and No-ASCVD groups. Peak CK-MB levels were lower in 
      statin users (10 versus 25 ng/ml, P < 0.0001). There was lower all-cause death 
      in-hospital and within 1 year for subjects with ASCVD already on statins 
      independent of other baseline variables. There were no differences in all-cause 
      death for No-ASCVD patients whether or not on statins. CONCLUSIONS: statin 
      pretreatment was associated with more favourable ACS presentation and lower 
      myocardial damage in older ACS patients both ASCVD and No-ASCVD. The incidence of 
      all-cause death (in-hospital and within 1 year) was significantly lower in the 
      statin treated ASCVD patients.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      British Geriatrics Society. All rights reserved. For permissions, please email: 
      journals.permissions@oup.com.
FAU - Toso, Anna
AU  - Toso A
AUID- ORCID: 0000-0002-8404-3993
AD  - Ospedale S. Stefano, Division of Cardiology, Prato, Italy.
FAU - Morici, Nuccia
AU  - Morici N
AD  - IRCCS S. Maria Nascente - Fondazione Don Carlo Gnocchi ONLUS, Cardiology 
      Rehabilitation Unit, Milan, Italy.
FAU - Leoncini, Mario
AU  - Leoncini M
AD  - Ospedale S. Stefano, Division of Cardiology, Prato, Italy.
FAU - Villani, Simona
AU  - Villani S
AD  - Biostatistica ed Epidemiologia Clinica, Department of Public Health, 
      Neurosciences, Experimental and Forensic Medicine, Universita di Pavia, Pavia, 
      Italy.
FAU - Ferri, Luca A
AU  - Ferri LA
AD  - San Raffaele Scientific Institute, Operative Unit of Hemodynamics and 
      Interventional Cardiology, Milan, Italy.
FAU - Piatti, Luigi
AU  - Piatti L
AD  - Ospedale Manzoni, Cardiovascular Department, Lecco, Italy.
FAU - Grosseto, Daniele
AU  - Grosseto D
AD  - Ospedale Infermi, Division of Cardiology, Rimini, Italy.
FAU - Bossi, Irene
AU  - Bossi I
AD  - ASST Grande Ospedale Metropolitano Niguarda, Division of Cardiology, Milano, 
      Italy.
FAU - Sganzerla, Paolo
AU  - Sganzerla P
AD  - IRCCS Auxologico San Luca, Laboratory of Catheterization, Milan, Italy.
FAU - Tortorella, Giovanni
AU  - Tortorella G
AD  - Ospedale Vaio, Medical and Diagnostic Department, Fidenza, Italy.
FAU - Cacucci, Michele
AU  - Cacucci M
AD  - Ospedale Maggiore, Division of Cardiology, Crema, Italy.
FAU - Ferrario, Maurizio
AU  - Ferrario M
AD  - IRCCS Fondazione Policlinico S. Matteo, Cardiothoracovascular Department and 
      Molecular Medicine, Pavia, Italy.
FAU - Tondi, Stefano
AU  - Tondi S
AD  - Ospedale Baggiovara, Cardiology Unit, Modena, Italy.
FAU - Ravera, Amelia
AU  - Ravera A
AD  - Ospedale Ruggi D' Aragona, Cardiology Intensive Care Unit, Salerno, Italy.
FAU - Bellandi, Francesco
AU  - Bellandi F
AD  - Ospedale S. Stefano, Division of Cardiology, Prato, Italy.
FAU - Cavallini, Claudio
AU  - Cavallini C
AD  - Ospedale S. Maria della Misericordia, Cardiothoracovascular Department, Perugia, 
      Italy.
FAU - Antonicelli, Roberto
AU  - Antonicelli R
AD  - Istituto Nazionale di Ricerca e Cura per l' Anziano, Cardiology Complex Operating 
      Unit, Ancona, Italy.
FAU - De Servi, Stefano
AU  - De Servi S
AD  - IRCCS Fondazione Policlinico S. Matteo, Cardiothoracovascular Department and 
      Molecular Medicine, Pavia, Italy.
FAU - Savonitto, Stefano
AU  - Savonitto S
AD  - Ospedale Manzoni, Cardiovascular Department, Lecco, Italy.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Age Ageing
JT  - Age and ageing
JID - 0375655
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
EIN - Age Ageing. 2023 May 1;52(5):. PMID: 37211368
MH  - *Acute Coronary Syndrome/diagnosis/drug therapy
MH  - Aged
MH  - Humans
MH  - *Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
MH  - Incidence
MH  - Prognosis
MH  - *ST Elevation Myocardial Infarction/diagnosis/drug therapy
OTO - NOTNLM
OT  - acute coronary syndrome
OT  - atherosclerotic cardiovascular disease
OT  - older people
OT  - statins
EDAT- 2022/06/19 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/06/18 05:42
PHST- 2021/12/09 00:00 [received]
PHST- 2022/03/28 00:00 [revised]
PHST- 2022/06/18 05:42 [entrez]
PHST- 2022/06/19 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
AID - 6610925 [pii]
AID - 10.1093/ageing/afac121 [doi]
PST - ppublish
SO  - Age Ageing. 2022 Jun 1;51(6):afac121. doi: 10.1093/ageing/afac121.