PMID- 35716931
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20220930
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 363
DP  - 2022 Sep 15
TI  - Left atrioventricular coupling index in hypertrophic cardiomyopathy and risk of 
      new-onset atrial fibrillation.
PG  - 87-93
LID - S0167-5273(22)00916-0 [pii]
LID - 10.1016/j.ijcard.2022.06.017 [doi]
AB  - BACKGROUNDS: This study aimed to investigate the association between left 
      atrioventricular coupling index (LACI) and the occurrence of atrial fibrillation 
      (AF) in patients with hypertrophic cardiomyopathy (HCM). METHODS: A total of 373 
      patients with HCM and no history of AF were evaluated by transthoracic 
      echocardiography. LACI was defined by the ratio of left atrial (LA) end-diastolic 
      volume divided by left ventricular (LV) end-diastolic volume. The cut-off value 
      for LACI (>/=40%) to identify LA-LV uncoupling was chosen based on the risk excess 
      of new-onset AF described with a spline curve analysis. RESULTS: The median LACI 
      was 37.5% (IQR: 24.4-56.7) and LA-LV uncoupling (LACI >/=40%) was observed in 171 
      (45.8%) patients. During a median follow-up of 11 (IQR 7-15) years, 118 (31.6%) 
      subjects developed new-onset AF. The cumulative event-free survival at 10 years 
      was 53% for patients with LA-LV uncoupling versus 94% for patients without LA-LV 
      uncoupling (p < 0.001). Multivariable Cox regression analyses performed 
      separately for each LA parameter showed an independent association between 
      new-onset AF and LACI (hazard ratio [HR], 1.021; 95% CI, 1.017-1.026), LA maximum 
      volume indexed (HR, 1.028; 95% CI, 1.017-1.039), LA minimum volume indexed (HR, 
      1.047; 95% CI, 1.037-1.060) and LA emptying fraction (HR, 0.967; 95% CI, 
      0.959-0.977, all p < 0.001). The inclusion of LACI in the multivariate model 
      provided a larger improvement in the risk stratification for new-onset AF, as 
      compared to conventional LA parameters. CONCLUSION: In patients with HCM, LACI 
      was more predictive of the occurrence of new-onset AF than conventional LA 
      parameters.
CI  - Copyright (c) 2022 The Author(s). Published by Elsevier B.V. All rights reserved.
FAU - Meucci, Maria Chiara
AU  - Meucci MC
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, the 
      Netherlands; Department of Cardiovascular and Thoracic Sciences, Fondazione 
      Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred 
      Heart, Rome, Italy.
FAU - Fortuni, Federico
AU  - Fortuni F
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Galloo, Xavier
AU  - Galloo X
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, the 
      Netherlands; Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel 
      (UZ Brussel), Department of Cardiology, Brussels, Belgium.
FAU - Bootsma, Marianne
AU  - Bootsma M
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Crea, Filippo
AU  - Crea F
AD  - Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico 
      Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, 
      Italy.
FAU - Bax, Jeroen J
AU  - Bax JJ
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, the 
      Netherlands; Heart Center, University of Turku and Turku University Hospital, 
      Turku, Finland.
FAU - Marsan, Nina Ajmone
AU  - Marsan NA
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Delgado, Victoria
AU  - Delgado V
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, the 
      Netherlands; Hospital University Germans Trias i Pujol, Fundacio Institut 
      d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, Badalona, Spain. 
      Electronic address: v.delgado@lumc.nl.
LA  - eng
PT  - Journal Article
DEP - 20220615
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
CIN - Int J Cardiol. 2022 Nov 15;367:27-28. PMID: 35988670
MH  - *Atrial Fibrillation/diagnostic imaging/epidemiology
MH  - *Cardiomyopathy, Hypertrophic/diagnostic imaging/epidemiology
MH  - Echocardiography
MH  - Heart Atria
MH  - Heart Ventricles
MH  - Humans
OTO - NOTNLM
OT  - Atrial fibrillation
OT  - Atrial remodeling
OT  - Echocardiography
OT  - Hypertrophic cardiomyopathy
EDAT- 2022/06/19 06:00
MHDA- 2022/07/20 06:00
CRDT- 2022/06/18 19:36
PHST- 2022/04/16 00:00 [received]
PHST- 2022/06/04 00:00 [revised]
PHST- 2022/06/10 00:00 [accepted]
PHST- 2022/06/19 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2022/06/18 19:36 [entrez]
AID - S0167-5273(22)00916-0 [pii]
AID - 10.1016/j.ijcard.2022.06.017 [doi]
PST - ppublish
SO  - Int J Cardiol. 2022 Sep 15;363:87-93. doi: 10.1016/j.ijcard.2022.06.017. Epub 
      2022 Jun 15.