PMID- 35717524
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20240214
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Jun 18
TI  - Early-life stress exposure and large-scale covariance brain networks in extremely 
      preterm-born infants.
PG  - 256
LID - 10.1038/s41398-022-02019-4 [doi]
LID - 256
AB  - The stressful extrauterine environment following premature birth likely has 
      far-reaching and persistent adverse consequences. The effects of early 
      "third-trimester" ex utero stress on large-scale brain networks' covariance 
      patterns may provide a potential avenue to understand how early-life stress 
      following premature birth increases risk or resilience. We evaluated the impact 
      of early-life stress exposure (e.g., quantification of invasive procedures) on 
      maturational covariance networks (MCNs) between 30 and 40 weeks of gestational 
      age in 180 extremely preterm-born infants (<28 weeks of gestation; 43.3% female). 
      We constructed MCNs using covariance of gray matter volumes between key nodes of 
      three large-scale brain networks: the default mode network (DMN), executive 
      control network (ECN), and salience network (SN). Maturational coupling was 
      quantified by summating the number of within- and between-network connections. 
      Infants exposed to high stress showed significantly higher SN but lower DMN 
      maturational coupling, accompanied by DMN-SN decoupling. Within the SN, the 
      insula, amygdala, and subthalamic nucleus all showed higher maturational 
      covariance at the nodal level. In contrast, within the DMN, the hippocampus, 
      parahippocampal gyrus, and fusiform showed lower coupling following stress. The 
      decoupling between DMN-SN was observed between the insula/anterior cingulate 
      cortex and posterior parahippocampal gyrus. Early-life stress showed longitudinal 
      network-specific maturational covariance patterns, leading to a reprioritization 
      of developmental trajectories of the SN at the cost of the DMN. These alterations 
      may enhance the ability to cope with adverse stimuli in the short term but 
      simultaneously render preterm-born individuals at a higher risk for 
      stress-related psychopathology later in life.
CI  - (c) 2022. The Author(s).
FAU - Lammertink, Femke
AU  - Lammertink F
AUID- ORCID: 0000-0003-3481-2544
AD  - Department of Neonatology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands.
FAU - van den Heuvel, Martijn P
AU  - van den Heuvel MP
AD  - Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive 
      Research, Amsterdam Neuroscience, Vrije University Amsterdam, Amsterdam, The 
      Netherlands.
AD  - Department of Child Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, 
      The Netherlands.
FAU - Hermans, Erno J
AU  - Hermans EJ
AD  - Donders Institute for Brain, Cognition, and Behaviour, Radboud University, 
      Nijmegen, The Netherlands.
AD  - Department of Cognitive Neuroscience, Radboud University Medical Center, 
      Nijmegen, The Netherlands.
FAU - Dudink, Jeroen
AU  - Dudink J
AD  - Department of Neonatology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands.
FAU - Tataranno, Maria L
AU  - Tataranno ML
AD  - Department of Neonatology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands.
FAU - Benders, Manon J N L
AU  - Benders MJNL
AUID- ORCID: 0000-0001-5491-9168
AD  - Department of Neonatology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands. m.benders@umcutrecht.nl.
FAU - Vinkers, Christiaan H
AU  - Vinkers CH
AUID- ORCID: 0000-0003-3698-0744
AD  - Department of Anatomy & Neurosciences, Amsterdam UMC (location Vrije University 
      Amsterdam), Amsterdam, The Netherlands.
AD  - Department of Psychiatry, Amsterdam UMC (location Vrije University Amsterdam), 
      Amsterdam, The Netherlands.
LA  - eng
GR  - EP-C-16-015/EPA/EPA/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220618
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
SB  - IM
EIN - Transl Psychiatry. 2022 Jul 8;12(1):269. PMID: 35803903
MH  - *Adverse Childhood Experiences
MH  - *Brain/diagnostic imaging/growth & development
MH  - *Brain Mapping
MH  - Female
MH  - Humans
MH  - *Infant, Extremely Premature
MH  - Infant, Newborn
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/diagnostic imaging
MH  - *Premature Birth
PMC - PMC9206645
COIS- The content is the sole responsibility of the authors and does not necessarily 
      represent the official views of the funding agencies. The authors declare that 
      the research was conducted in the absence of any commercial or financial 
      relationships that could be construed as a potential conflict of interest.
EDAT- 2022/06/19 06:00
MHDA- 2022/06/22 06:00
PMCR- 2022/06/18
CRDT- 2022/06/18 23:55
PHST- 2021/03/11 00:00 [received]
PHST- 2022/06/07 00:00 [accepted]
PHST- 2022/05/25 00:00 [revised]
PHST- 2022/06/18 23:55 [entrez]
PHST- 2022/06/19 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/06/18 00:00 [pmc-release]
AID - 10.1038/s41398-022-02019-4 [pii]
AID - 2019 [pii]
AID - 10.1038/s41398-022-02019-4 [doi]
PST - epublish
SO  - Transl Psychiatry. 2022 Jun 18;12(1):256. doi: 10.1038/s41398-022-02019-4.