PMID- 35718230
OWN - NLM
STAT- MEDLINE
DCOM- 20220721
LR  - 20220726
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 432
DP  - 2022 Aug 26
TI  - Repeated administration of rapastinel produces exceptionally prolonged rescue of 
      memory deficits in phencyclidine-treated mice.
PG  - 113964
LID - S0166-4328(22)00232-7 [pii]
LID - 10.1016/j.bbr.2022.113964 [doi]
AB  - Rapastinel, a positive N-methyl-D-aspartate receptor (NMDAR) modulator with 
      rapid-acting antidepressant properties, rescues memory deficits in rodents. We 
      have previously reported that a single intravenous dose of rapastinel, 
      significantly, but only transiently, prevented and rescued deficits in the novel 
      object recognition (NOR) test, a measure of episodic memory, produced by acute or 
      subchronic administration of the NMDAR antagonists, phencyclidine (PCP) and 
      ketamine. Here, we tested the ability of single and multiple subcutaneous doses 
      per day of rapastinel to restore NOR and operant reversal learning (ORL) deficits 
      in subchronic PCP-treated mice. Rapastinel, 1 or 3 mg/kg, administered 
      subcutaneously, 30 min before NOR or ORL testing, respectively, transiently 
      rescued both deficits in subchronic PCP mice. This effect of rapastinel on NOR 
      and ORL was mammalian target of rapamycin (mTOR)-dependent. Most importantly, 
      1 mg/kg rapastinel given twice daily for 3 or 5 days, but not 1 day, restored NOR 
      for at least 9 and 10 weeks, respectively, which is an indication of neuroplastic 
      effects on learning and memory. Both rapastinel (3 mg/kg) and ketamine 
      (30 mg/kg), moderately increased the efflux of dopamine, norepinephrine, and 
      serotonin in medial prefrontal cortex; however, only ketamine increased cortical 
      glutamate efflux. This observation was likely the basis for the contrasting 
      effects of the two drugs on cognition.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Rajagopal, Lakshmi
AU  - Rajagopal L
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - Huang, Mei
AU  - Huang M
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - He, Wenqi
AU  - He W
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of 
      Medicine, Chicago, IL, USA. Electronic address: gzwenqihe@163.com.
FAU - Ryan, Chelsea
AU  - Ryan C
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - Elzokaky, Ahmad
AU  - Elzokaky A
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - Banerjee, Pradeep
AU  - Banerjee P
AD  - Allergan, Madison, NJ, USA.
FAU - Meltzer, Herbert Y
AU  - Meltzer HY
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of 
      Medicine, Chicago, IL, USA. Electronic address: h-meltzer@northwestern.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220617
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Oligopeptides)
RN  - 690G0D6V8H (Ketamine)
RN  - 6A1X56B95E (GLYX-13 peptide)
RN  - J1DOI7UV76 (Phencyclidine)
SB  - IM
MH  - Animals
MH  - *Ketamine/pharmacology/therapeutic use
MH  - Mammals
MH  - Memory Disorders/chemically induced/drug therapy
MH  - Mice
MH  - Oligopeptides/pharmacology
MH  - *Phencyclidine/pharmacology
OTO - NOTNLM
OT  - Antidepressant
OT  - Ketamine
OT  - Novel object recognition
OT  - Operant reversal learning
OT  - Phencyclidine
OT  - Rapastinel
EDAT- 2022/06/20 06:00
MHDA- 2022/07/22 06:00
CRDT- 2022/06/19 19:34
PHST- 2022/02/21 00:00 [received]
PHST- 2022/06/07 00:00 [revised]
PHST- 2022/06/09 00:00 [accepted]
PHST- 2022/06/20 06:00 [pubmed]
PHST- 2022/07/22 06:00 [medline]
PHST- 2022/06/19 19:34 [entrez]
AID - S0166-4328(22)00232-7 [pii]
AID - 10.1016/j.bbr.2022.113964 [doi]
PST - ppublish
SO  - Behav Brain Res. 2022 Aug 26;432:113964. doi: 10.1016/j.bbr.2022.113964. Epub 
      2022 Jun 17.