PMID- 35718252
OWN - NLM
STAT- MEDLINE
DCOM- 20220714
LR  - 20220727
IS  - 1872-8294 (Electronic)
IS  - 0169-409X (Linking)
VI  - 187
DP  - 2022 Aug
TI  - Cell-based drug delivery systems and their in vivo fate.
PG  - 114394
LID - S0169-409X(22)00284-8 [pii]
LID - 10.1016/j.addr.2022.114394 [doi]
AB  - Cell-based drug delivery systems (DDSs) have received attention recently because 
      of their unique biological properties and self-powered functions, such as 
      excellent biocompatibility, low immunogenicity, long circulation time, 
      tissue-homingcharacteristics, and ability to cross biological barriers. A variety 
      of cells, including erythrocytes, stem cells, and lymphocytes, have been explored 
      as functional vectors for the loading and delivery of various therapeutic 
      payloads (e.g., small-molecule and nucleic acid drugs) for subsequent disease 
      treatment. These cell-based DDSs have their own unique in vivo fates, which are 
      attributed to various factors, including their biological properties and 
      functions, the loaded drugs and loading process, physiological and pathological 
      circumstances, and the body's response to these carrier cells, which result in 
      differences in drug delivery efficiency and therapeutic effect. In this review, 
      we summarize the main cell-based DDSs and their biological properties and 
      functions, applications in drug delivery and disease treatment, and in vivo fate 
      and influencing factors. We envision that the unique biological properties, 
      combined with continuing research, will enable development of cell-based DDSs as 
      friendly drug vectors for the safe, effective, and even personalized treatment of 
      diseases.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Yang, Liuxin
AU  - Yang L
AD  - School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
FAU - Yang, Yang
AU  - Yang Y
AD  - School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
FAU - Chen, Yang
AU  - Chen Y
AD  - School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
FAU - Xu, Yuhong
AU  - Xu Y
AD  - School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China; 
      School of Pharmacy, DaLi University, Dali City 671000, PR China.
FAU - Peng, Jinliang
AU  - Peng J
AD  - School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China. 
      Electronic address: pjl76@sjtu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220617
PL  - Netherlands
TA  - Adv Drug Deliv Rev
JT  - Advanced drug delivery reviews
JID - 8710523
RN  - 0 (Drug Carriers)
RN  - 0 (Nucleic Acids)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Drug Carriers
MH  - *Drug Delivery Systems
MH  - Humans
MH  - *Nucleic Acids
MH  - Pharmaceutical Preparations
OTO - NOTNLM
OT  - Biological property
OT  - Carrier cell
OT  - Disease treatment
OT  - Drug delivery
OT  - In vivo fate
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/06/20 06:00
MHDA- 2022/07/15 06:00
CRDT- 2022/06/19 19:34
PHST- 2022/03/31 00:00 [received]
PHST- 2022/05/17 00:00 [revised]
PHST- 2022/06/07 00:00 [accepted]
PHST- 2022/06/20 06:00 [pubmed]
PHST- 2022/07/15 06:00 [medline]
PHST- 2022/06/19 19:34 [entrez]
AID - S0169-409X(22)00284-8 [pii]
AID - 10.1016/j.addr.2022.114394 [doi]
PST - ppublish
SO  - Adv Drug Deliv Rev. 2022 Aug;187:114394. doi: 10.1016/j.addr.2022.114394. Epub 
      2022 Jun 17.