PMID- 35718709
OWN - NLM
STAT- MEDLINE
DCOM- 20220928
LR  - 20231213
IS  - 1440-1592 (Electronic)
IS  - 1323-8930 (Print)
IS  - 1323-8930 (Linking)
VI  - 71
IP  - 4
DP  - 2022 Oct
TI  - Serum polyethylene glycol-specific IgE and IgG in patients with hypersensitivity 
      to COVID-19 mRNA vaccines.
PG  - 512-519
LID - S1323-8930(22)00048-X [pii]
LID - 10.1016/j.alit.2022.05.007 [doi]
AB  - BACKGROUND: The mechanism of allergic reactions to COVID-19 mRNA vaccines has not 
      been clarified. Polyethylene glycol (PEG) is a potential antigen in the 
      components of vaccines. However, there is little evidence that allergy after 
      COVID-19 mRNA vaccination is related to PEG. Furthermore, the role of polysorbate 
      (PS) as an antigen has also not been clarified. The objective of this study was 
      to investigate whether PEG and PS allergies are reasonable causes of allergic 
      symptoms after vaccination by detecting PEG-specific and PS-specific antibodies. 
      METHODS: Fourteen patients who developed immediate allergic reactions to BNT162b2 
      (Pfizer-BioNTech) or mRNA-1273 (Moderna) vaccines and nineteen healthy controls 
      who did not present allergic symptoms were recruited. Serum PEG-specific 
      immunoglobulin E (IgE) and immunoglobulin G (IgG) and PS-specific IgE and IgG 
      were measured by enzyme-linked immunosorbent assay. Skin tests using PEG-2000 and 
      PS-80 were applied to five patients and three controls. RESULTS: Serum levels of 
      PEG-specific IgE and IgG in patients with immediate allergic reactions to the 
      COVID-19 mRNA vaccine were higher than those in the control group. Serum levels 
      of PS-specific IgE in patients with allergy to the vaccine were higher than those 
      in patients of the control group. Intradermal tests using PEG verified the 
      results for PEG-specific IgE and IgG. CONCLUSIONS: The results suggest that PEG 
      is one of the antigens in the allergy to COVID-19 mRNA vaccines. Cross-reactivity 
      between PEG and PS might be crucial for allergy to the vaccines. PEG-specific IgE 
      and IgG may be useful in diagnosing allergy to COVID-19 mRNA vaccines.
CI  - Copyright (c) 2022 Japanese Society of Allergology. Production and hosting by 
      Elsevier B.V. All rights reserved.
FAU - Mouri, Mariko
AU  - Mouri M
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan; Department of 
      Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
FAU - Imamura, Mitsuru
AU  - Imamura M
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan. Electronic address: 
      mitsuru.imamura@marianna-u.ac.jp.
FAU - Suzuki, Shotaro
AU  - Suzuki S
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan.
FAU - Kawasaki, Tatsuya
AU  - Kawasaki T
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan.
FAU - Ishizaki, Yoshiki
AU  - Ishizaki Y
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan.
FAU - Sakurai, Keiichi
AU  - Sakurai K
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan.
FAU - Nagafuchi, Hiroko
AU  - Nagafuchi H
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan.
FAU - Matsumura, Norihiro
AU  - Matsumura N
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan.
FAU - Uchida, Marina
AU  - Uchida M
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan.
FAU - Ando, Takayasu
AU  - Ando T
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan.
FAU - Yoshioka, Kohei
AU  - Yoshioka K
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan.
FAU - Ooka, Seido
AU  - Ooka S
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan.
FAU - Sugihara, Takahiko
AU  - Sugihara T
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan.
FAU - Miyoshi, Hiroshi
AU  - Miyoshi H
AD  - Department of Microbiology, St. Marianna University School of Medicine, Kanagawa, 
      Japan.
FAU - Mori, Masaaki
AU  - Mori M
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan; Department of Lifetime 
      Clinical Immunology, Tokyo Medical and Dental University, Tokyo, Japan; Livelong 
      Care Center for Rheumatic Diseases, Division of Rheumatology and Allergology, 
      Department of Internal Medicine, St. Marianna University School of Medicine, 
      Kanagawa, Japan.
FAU - Okada, Tomoyuki
AU  - Okada T
AD  - Department of Otolaryngology and Health Service Center, St. Marianna University 
      School of Medicine, Kawasaki, Japan.
FAU - Yamaguchi, Masao
AU  - Yamaguchi M
AD  - Division of Respiratory Medicine, Third Department of Medicine, Teikyo University 
      Chiba Medical Center, Chiba, Japan.
FAU - Kunishima, Hiroyuki
AU  - Kunishima H
AD  - Department of Infectious Disease, St. Marianna University School of Medicine, 
      Kanagawa, Japan.
FAU - Kato, Motohiro
AU  - Kato M
AD  - Department of Pediatrics, Graduate School of Medicine, University of Tokyo, 
      Tokyo, Japan.
FAU - Kawahata, Kimito
AU  - Kawahata K
AD  - Division of Rheumatology and Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kanagawa, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220606
PL  - England
TA  - Allergol Int
JT  - Allergology international : official journal of the Japanese Society of 
      Allergology
JID - 9616296
RN  - 0 (COVID-19 Vaccines)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Polysorbates)
RN  - 0 (RNA, Messenger)
RN  - 0 (Vaccines, Synthetic)
RN  - 0 (mRNA Vaccines)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - N38TVC63NU (BNT162 Vaccine)
SB  - IM
MH  - BNT162 Vaccine/*adverse effects
MH  - *COVID-19/diagnosis/prevention & control
MH  - COVID-19 Vaccines/adverse effects
MH  - Humans
MH  - *Hypersensitivity/diagnosis
MH  - Hypersensitivity, Immediate
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - Polyethylene Glycols
MH  - Polysorbates
MH  - RNA, Messenger
MH  - Vaccines, Synthetic
MH  - mRNA Vaccines
PMC - PMC9167845
OTO - NOTNLM
OT  - COVID-19 mRNA vaccines
OT  - PEG-specific IgE
OT  - PEG-specific IgG
OT  - Polyethylene glycol
OT  - Polysorbate
EDAT- 2022/06/20 06:00
MHDA- 2022/09/28 06:00
PMCR- 2022/06/06
CRDT- 2022/06/19 22:19
PHST- 2022/02/09 00:00 [received]
PHST- 2022/05/02 00:00 [revised]
PHST- 2022/05/10 00:00 [accepted]
PHST- 2022/06/20 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2022/06/19 22:19 [entrez]
PHST- 2022/06/06 00:00 [pmc-release]
AID - S1323-8930(22)00048-X [pii]
AID - 10.1016/j.alit.2022.05.007 [doi]
PST - ppublish
SO  - Allergol Int. 2022 Oct;71(4):512-519. doi: 10.1016/j.alit.2022.05.007. Epub 2022 
      Jun 6.