PMID- 35719024
OWN - NLM
STAT- MEDLINE
DCOM- 20230328
LR  - 20230531
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Print)
IS  - 1751-7885 (Linking)
VI  - 17
IP  - 3
DP  - 2023 Mar
TI  - Family communication and the efficacy of family focused therapy in individuals at 
      clinical high risk for psychosis with comorbid anxiety.
PG  - 281-289
LID - 10.1111/eip.13326 [doi]
AB  - AIM: Comorbid anxiety disorder is related to greater illness severity among 
      individuals at clinical high risk (CHR) for psychosis, but its potential role in 
      moderating response to Family Focused Therapy (FFT) for CHR is unexamined. We 
      investigated whether comorbid anxiety disorder in CHR individuals is associated 
      with less constructive communication during family problem-solving interactions, 
      whether their communication skills differentially improve after FFT, and whether 
      FFT is effective in reducing anxiety in this population. METHODS: Individuals 
      recruited into the second phase of the 8-site North American Prodrome 
      Longitudinal Study (NAPLS2) participated (N = 129). They were randomly assigned 
      to 18-sessions of FFT-CHR or three-sessions of Enhanced Care (EC). Participants 
      completed a diagnostic interview at pre-treatment, a family interaction task at 
      pre-treatment and 6-months, and a self-report anxiety measure at pretreatment, 6 
      and 12-months. RESULTS: Individuals at CHR with comorbid anxiety engaged in more 
      negative and fewer positive behaviours during family problem-solving interactions 
      at pre-treatment than did those without comorbid anxiety. There was a significant 
      interaction between anxiety diagnosis and time on interactional behaviour scores, 
      such that individuals at CHR with an anxiety diagnosis showed a greater decrease 
      in negative behaviours and increase in positive behaviours from baseline to 
      6-months than those without anxiety disorder(s) regardless of treatment 
      condition. However, individuals' self-reported anxiety symptoms decreased more in 
      FFT-CHR than in EC from pre-treatment to 12-month follow-up, regardless of 
      anxiety diagnoses. CONCLUSIONS: Individuals at CHR with symptoms of anxiety 
      benefit from family interventions in showing reductions in anxiety and 
      improvements in family communication.
CI  - (c) 2022 John Wiley & Sons Australia, Ltd.
FAU - O'Brien Cannon, Arianna C
AU  - O'Brien Cannon AC
AUID- ORCID: 0000-0003-0765-9775
AD  - Department of Psychology, American University, Washington, District of Columbia, 
      USA.
FAU - Caporino, Nicole E
AU  - Caporino NE
AD  - Department of Psychology, American University, Washington, District of Columbia, 
      USA.
FAU - O'Brien, Mary P
AU  - O'Brien MP
AD  - Department of Psychology, Yale University, New Haven, Connecticut, USA.
FAU - Miklowitz, David J
AU  - Miklowitz DJ
AUID- ORCID: 0000-0002-9647-6147
AD  - Department of Psychiatry and Biobehavioral Sciences, Semel Institute for 
      Neuroscience and Behavior, University of California, California, Los Angeles, 
      USA.
FAU - Addington, Jean M
AU  - Addington JM
AUID- ORCID: 0000-0002-8298-0756
AD  - Department of Psychiatry, University of Calgary, Calgary, Canada.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Department of Psychology, Yale University, New Haven, Connecticut, USA.
LA  - eng
GR  - R01 MH123575/MH/NIMH NIH HHS/United States
GR  - MH088546/NH/NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220619
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
SB  - IM
MH  - Humans
MH  - Anxiety/complications/therapy
MH  - Anxiety Disorders
MH  - Communication
MH  - Longitudinal Studies
MH  - Prodromal Symptoms
MH  - *Psychotic Disorders/complications/therapy/diagnosis
PMC - PMC10228682
MID - NIHMS1899521
OTO - NOTNLM
OT  - anxiety
OT  - clinical high risk for psychosis
OT  - enhanced care
OT  - family focused treatment
OT  - family problem-solving interaction task
EDAT- 2022/06/21 06:00
MHDA- 2023/03/22 06:00
PMCR- 2023/05/30
CRDT- 2022/06/20 02:03
PHST- 2022/03/31 00:00 [revised]
PHST- 2021/08/20 00:00 [received]
PHST- 2022/05/29 00:00 [accepted]
PHST- 2022/06/21 06:00 [pubmed]
PHST- 2023/03/22 06:00 [medline]
PHST- 2022/06/20 02:03 [entrez]
PHST- 2023/05/30 00:00 [pmc-release]
AID - 10.1111/eip.13326 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2023 Mar;17(3):281-289. doi: 10.1111/eip.13326. Epub 
      2022 Jun 19.