PMID- 35719140
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Optimized Extraction of cAMP From Jujube by Ultra-High Pressure Technology and 
      the Anti-allergic Effect for Peanut Allergy Mouse.
PG  - 862900
LID - 10.3389/fnut.2022.862900 [doi]
LID - 862900
AB  - Jujube contains abundant cyclic adenosine monophosphate (cAMP). In contrast, the 
      extraction technology of cAMP from jujube is still to be explored. In this study, 
      the ultra-high pressure extraction (UHPE) conditions for obtaining the maximum 
      cAMP yield from jujube were optimized. Orthogonal array design (OAD) was applied 
      to evaluate the effects of three variables (pressure, pressure-holding time, and 
      liquid-to-solid ratio) by UHPE on cAMP yield. The results showed that the optimal 
      cAMP yield (1223.2 mug/g) was derived at 300 MPa, 20 min duration, and a 
      liquid-to-solid ratio of 2.5 ml/g. In addition, as an important functional 
      ingredient in jujube, cAMP has potential anti-allergic effect. To develop the 
      functional characteristics of jujube, the effect of cAMP was characterized in 
      vivo with the Balb/c mouse model of peanut allergy, which was established by 
      subcutaneous injection of crude peanut protein extract (PN). The results showed 
      that treatment with cAMP in PN-sensitized mice suppressed the lesions in jejunal 
      tissues and allergic symptoms and restored spleen index. Meanwhile, cAMP 
      treatment reduced serum levels of specific immunoglobulin E (IgE), histamine, as 
      well as interleukin-4 (IL-4) and stimulated the secretion of tumor necrosis 
      factor-alpha (TNF-alpha), whereas the serum levels of interleukin-10 (IL-10) were not 
      affected. Our results suggested that cAMP has an anti-allergic effect in 
      PN-sensitized mice.
CI  - Copyright (c) 2022 Sang, Bai, Feng, Wu, Liu, Gao and Long.
FAU - Sang, Chaowei
AU  - Sang C
AD  - College of Food Science and Enginering, Northwest A&F University, Xianyang, 
      China.
FAU - Bai, Qiao
AU  - Bai Q
AD  - College of Food Science and Enginering, Northwest A&F University, Xianyang, 
      China.
FAU - Feng, Xiaoping
AU  - Feng X
AD  - College of Food Science and Enginering, Northwest A&F University, Xianyang, 
      China.
FAU - Wu, Chunyu
AU  - Wu C
AD  - College of Food Science and Enginering, Northwest A&F University, Xianyang, 
      China.
FAU - Liu, Ye
AU  - Liu Y
AD  - Beijing Key Lab of Plant Resource Research and Development, Beijing Technology 
      and Business University, Beijing, China.
FAU - Gao, Zhenpeng
AU  - Gao Z
AD  - College of Food Science and Enginering, Northwest A&F University, Xianyang, 
      China.
FAU - Long, Fangyu
AU  - Long F
AD  - College of Food Science and Enginering, Northwest A&F University, Xianyang, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20220526
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9199853
OTO - NOTNLM
OT  - Balb/c mouse model
OT  - cyclic adenosine monophosphate
OT  - jujube
OT  - peanut allergy
OT  - ultra-high pressure extraction
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The reviewer LS declared a shared affiliation with the 
      authors to the handling editor at time of review.
EDAT- 2022/06/21 06:00
MHDA- 2022/06/21 06:01
PMCR- 2022/01/01
CRDT- 2022/06/20 03:25
PHST- 2022/01/26 00:00 [received]
PHST- 2022/03/30 00:00 [accepted]
PHST- 2022/06/20 03:25 [entrez]
PHST- 2022/06/21 06:00 [pubmed]
PHST- 2022/06/21 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.862900 [doi]
PST - epublish
SO  - Front Nutr. 2022 May 26;9:862900. doi: 10.3389/fnut.2022.862900. eCollection 
      2022.