PMID- 35720357
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20230202
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells.
PG  - 906499
LID - 10.3389/fimmu.2022.906499 [doi]
LID - 906499
AB  - CD5 is constitutively expressed on all T cells and is a negative regulator of 
      lymphocyte function. However, the full extent of CD5 function in immunity remains 
      unclear. CD5 deficiency impacts thymic selection and extra-thymic regulatory T 
      cell generation, yet CD5 knockout was reported to cause no immune pathology. Here 
      we show that CD5 is a key modulator of gut immunity. We generated mice with 
      inducible CD5 knockdown (KD) in the autoimmune-prone nonobese diabetic (NOD) 
      background. CD5 deficiency caused T cell-dependent wasting disease driven by 
      chronic gut immune dysregulation. CD5 inhibition also exacerbated acute 
      experimental colitis. Mechanistically, loss of CD5 increased phospho-Stat3 
      levels, leading to elevated IL-17A secretion. Our data reveal a new facet of CD5 
      function in shaping the T cell cytokine profile.
CI  - Copyright (c) 2022 Schuster, Kiaf, Hatzihristidis, Ruckdeschel, Nieves-Bonilla, 
      Ishikawa, Zhao, Zheng, Love and Kissler.
FAU - Schuster, Cornelia
AU  - Schuster C
AD  - Joslin Diabetes Center, Harvard Medical School, Boston, MA, United States.
FAU - Kiaf, Badr
AU  - Kiaf B
AD  - Joslin Diabetes Center, Harvard Medical School, Boston, MA, United States.
FAU - Hatzihristidis, Teri
AU  - Hatzihristidis T
AD  - Section on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National 
      Institute of Child Health and Human Development, National Institutes of Health, 
      Bethesda, MD, United States.
FAU - Ruckdeschel, Anna
AU  - Ruckdeschel A
AD  - Joslin Diabetes Center, Harvard Medical School, Boston, MA, United States.
FAU - Nieves-Bonilla, Janice
AU  - Nieves-Bonilla J
AD  - Joslin Diabetes Center, Harvard Medical School, Boston, MA, United States.
FAU - Ishikawa, Yuki
AU  - Ishikawa Y
AD  - Joslin Diabetes Center, Harvard Medical School, Boston, MA, United States.
FAU - Zhao, Bin
AU  - Zhao B
AD  - Section on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National 
      Institute of Child Health and Human Development, National Institutes of Health, 
      Bethesda, MD, United States.
FAU - Zheng, Peilin
AU  - Zheng P
AD  - Rudolf Virchow Center for Experimental Biomedicine, Wurzburg, Germany.
FAU - Love, Paul E
AU  - Love PE
AD  - Section on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National 
      Institute of Child Health and Human Development, National Institutes of Health, 
      Bethesda, MD, United States.
FAU - Kissler, Stephan
AU  - Kissler S
AD  - Joslin Diabetes Center, Harvard Medical School, Boston, MA, United States.
LA  - eng
GR  - P30 DK036836/DK/NIDDK NIH HHS/United States
GR  - S10 OD021740/OD/NIH HHS/United States
GR  - P30 CA006516/CA/NCI NIH HHS/United States
GR  - R21 AI122110/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220602
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (CD5 Antigens)
SB  - IM
MH  - Animals
MH  - *CD5 Antigens
MH  - Lymphocyte Count
MH  - Mice
PMC - PMC9201032
OTO - NOTNLM
OT  - T cell
OT  - autoimmunity
OT  - costimulation
OT  - cytokines
OT  - mouse model
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/21 06:00
MHDA- 2022/06/22 06:00
PMCR- 2022/01/01
CRDT- 2022/06/20 03:41
PHST- 2022/03/28 00:00 [received]
PHST- 2022/05/10 00:00 [accepted]
PHST- 2022/06/20 03:41 [entrez]
PHST- 2022/06/21 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.906499 [doi]
PST - epublish
SO  - Front Immunol. 2022 Jun 2;13:906499. doi: 10.3389/fimmu.2022.906499. eCollection 
      2022.