PMID- 35721762
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20220724
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - The Lower Limit of Reference of Urinary Albumin/Creatinine Ratio and the Risk of 
      Chronic Kidney Disease Progression in Patients With Type 2 Diabetes Mellitus.
PG  - 858267
LID - 10.3389/fendo.2022.858267 [doi]
LID - 858267
AB  - A urine albumin/creatinine ratio (UACR) <30 mg/g is considered to be normal, 
      while increased risk of incident hypertension and cardiovascular disease 
      mortality in subjects with high normal UACR level had been observed. However, a 
      mild elevated but normal UACR level was associated with the risk of initiating 
      chronic kidney disease (CKD) is uncertain. We investigated whether higher normal 
      UACR is associated with the risk of developing CKD. A total of 4821 subjects with 
      type 2 diabetes mellitus (T2DM), an estimated glomerular filtration rate >60 
      ml/min/1.73 m(2) and UACR <30 mg/g enrolled in a diabetes disease management 
      program between 2006 and 2020 were studied. The optimal cutoff point for baseline 
      UACR as a predictor for progression to CKD according to the 2012 KDIGO definition 
      was calculated using receiving operating characteristic curve analysis. After a 
      mean of 4.9 years follow-up, the CKD risk progression increased in parallel with 
      the quartiles of baseline UACR <30 mg/g (p for trend <0.0001). UACR cutoff points 
      of 8.44 mg/g overall, 10.59 mg/g in males and 8.15 mg/g in females were 
      associated with the risk of CKD progression. In multivariate Cox regression 
      analysis, the hazard ratios for the association between UACR (>8.44 mg/g, >10.9 
      mg/g, >8.15 mg/g in overall, male, and female patients, respectively) and the 
      risk of CKD progression were significant. This study demonstrated that a cutoff 
      UACR value of >10 mg/g could significantly predict the cumulative incidence and 
      progression of CKD in patients with T2DM.
CI  - Copyright (c) 2022 Tang, Hung, Wang, Wu, Hsuan, Yu, Hsu, Cheng, Chung, Lee and Lu.
FAU - Tang, Wei-Hua
AU  - Tang WH
AD  - Division of Cardiology, Department of Internal Medicine, Taipei Veterans General 
      Hospital, Yuli Branch, Hualien, Taiwan.
AD  - Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
FAU - Hung, Wei-Chin
AU  - Hung WC
AD  - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, 
      Kaohsiung, Taiwan.
AD  - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
FAU - Wang, Chao-Ping
AU  - Wang CP
AD  - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, 
      Kaohsiung, Taiwan.
AD  - School of Medicine for International Students, College of Medicine, I-Shou 
      University, Kaohsiung, Taiwan.
FAU - Wu, Cheng-Ching
AU  - Wu CC
AD  - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, 
      Kaohsiung, Taiwan.
AD  - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
FAU - Hsuan, Chin-Feng
AU  - Hsuan CF
AD  - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, 
      Kaohsiung, Taiwan.
AD  - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
AD  - Division of Cardiology, Department of Internal Medicine, E-Da Dachang Hospital, 
      Kaohsiung, Taiwan.
FAU - Yu, Teng-Hung
AU  - Yu TH
AD  - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, 
      Kaohsiung, Taiwan.
AD  - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
FAU - Hsu, Chia-Chang
AU  - Hsu CC
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      E-Da Hospital, Kaohsiung, Taiwan.
AD  - The School of Chinese Medicine for Post Baccalaureate, College of Medicine, 
      I-Shou University, Kaohsiung, Taiwan.
FAU - Cheng, Ya-Ai
AU  - Cheng YA
AD  - Department of Health Care Administration, College of Medicine, I-Shou University, 
      Kaohsiung, Taiwan.
FAU - Chung, Fu-Mei
AU  - Chung FM
AD  - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, 
      Kaohsiung, Taiwan.
FAU - Lee, Yau-Jiunn
AU  - Lee YJ
AD  - Lee's Endocrinologic Clinic, Pingtung, Taiwan.
FAU - Lu, Yung-Chuan
AU  - Lu YC
AD  - School of Medicine for International Students, College of Medicine, I-Shou 
      University, Kaohsiung, Taiwan.
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, E-Da 
      Hospital, Kaohsiung, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220602
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Albumins)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Albumins
MH  - Albuminuria/complications/epidemiology
MH  - Creatinine
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Renal Insufficiency, Chronic/complications
PMC - PMC9200995
OTO - NOTNLM
OT  - Type 2 diabetes mellitus
OT  - chronic kidney disease
OT  - low-grade albuminuria
OT  - progression
OT  - risk
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/21 06:00
MHDA- 2022/06/22 06:00
PMCR- 2022/01/01
CRDT- 2022/06/20 03:59
PHST- 2022/01/29 00:00 [received]
PHST- 2022/05/02 00:00 [accepted]
PHST- 2022/06/20 03:59 [entrez]
PHST- 2022/06/21 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.858267 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Jun 2;13:858267. doi: 
      10.3389/fendo.2022.858267. eCollection 2022.