PMID- 35722372
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 10
IP  - 10
DP  - 2022 May
TI  - Shenfu injection attenuates cardiac dysfunction and inhibits apoptosis in septic 
      mice.
PG  - 597
LID - 10.21037/atm-22-836 [doi]
LID - 597
AB  - BACKGROUND: Cardiac dysfunction frequently occurs after sepsis and septic shock 
      and contributes to multiple organ failure. Shenfu injection, a well-known Chinese 
      medicine formulation, has recently been demonstrated to possess potential 
      cardio-protective effects, although its effect and mechanism in sepsis-induced 
      myocardial dysfunction remains unclear. METHODS: To investigate whether Shenfu 
      injection could alleviate myocardial injury and improve cardiac function, a model 
      of sepsis was induced by cecal ligation and puncture (CLP) surgery in C57BL/6 
      mice. Cardiac function, inflammatory factors, and apoptosis were evaluated in the 
      myocardium. RESULTS: Our results showed that the survival and left ventricular 
      function markedly declined when exposed to CLP compared with the sham procedure. 
      In contrast, Shenfu injection lowered mortality and prevented CLP from triggering 
      left ventricular dysfunction. Moreover, mice treated with Shenfu injection 
      exhibited noticeably decreased myocardial inflammatory cytokines [tumor necrosis 
      factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, and monocytechemoattractantprotein-1 
      (MCP-1)] and reduced apoptotic myocardiocytes death compared with mice that had 
      CLP. The activation of myocardial NF-small ka, CyrillicB detected in septic mice was suppressed by 
      the presence of Shenfu injection, as evidenced by decreased nuclear translocation 
      of the NF-small ka, CyrillicB p65 subunit. Moreover, Shenfu injection also prevented sepsis-caused 
      decreases in myocardial phospho-Akt and phospho-GSK-3beta in septic mice. 
      CONCLUSIONS: These data suggest that administration of Shenfu injection 
      attenuates cardiac dysfunction, protects against inflammatory injury, and reduces 
      apoptosis of myocardiocytes during sepsis by activating the AKT/GSK-3beta pathway.
CI  - 2022 Annals of Translational Medicine. All rights reserved.
FAU - Zhao, Liyun
AU  - Zhao L
AD  - Department of Critical Care Medicine, Guangdong Second Traditional Chinese 
      Medicine Hospital, Guangzhou, China.
FAU - Jin, Lili
AU  - Jin L
AD  - Department of Internal Medicine-Cardiovascular, Guangdong Second Traditional 
      Chinese Medicine Hospital, Guangzhou, China.
FAU - Luo, Yuanyuan
AU  - Luo Y
AD  - Department of Critical Care Medicine, First Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou, China.
FAU - Wang, Ling
AU  - Wang L
AD  - Department of Critical Care Medicine, Shenzhen Traditional Chinese Medicine 
      Hospital, Shenzhen, China.
FAU - Li, Yinghong
AU  - Li Y
AD  - Department of Internal Medicine-Cardiovascular, Guangdong Second Traditional 
      Chinese Medicine Hospital, Guangzhou, China.
FAU - Xian, Shaoxiang
AU  - Xian S
AD  - Department of Internal Medicine-Cardiovascular, First Affiliated Hospital of 
      Guangzhou University of Chinese Medicine, Guangzhou, China.
FAU - Zhao, Fengli
AU  - Zhao F
AD  - Department of Critical Care Medicine, First Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC9201198
OTO - NOTNLM
OT  - Sepsis-induced cardiac dysfunction
OT  - Shenfu injection
OT  - apoptosis
OT  - inflammation
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://atm.amegroups.com/article/view/10.21037/atm-22-836/coif). The authors 
      have no conflicts of interest to declare.
EDAT- 2022/06/21 06:00
MHDA- 2022/06/21 06:01
PMCR- 2022/05/01
CRDT- 2022/06/20 04:07
PHST- 2022/01/24 00:00 [received]
PHST- 2022/05/20 00:00 [accepted]
PHST- 2022/06/20 04:07 [entrez]
PHST- 2022/06/21 06:00 [pubmed]
PHST- 2022/06/21 06:01 [medline]
PHST- 2022/05/01 00:00 [pmc-release]
AID - atm-10-10-597 [pii]
AID - 10.21037/atm-22-836 [doi]
PST - ppublish
SO  - Ann Transl Med. 2022 May;10(10):597. doi: 10.21037/atm-22-836.