PMID- 35723362
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1467-3045 (Electronic)
IS  - 1467-3037 (Print)
IS  - 1467-3037 (Linking)
VI  - 44
IP  - 4
DP  - 2022 Apr 1
TI  - Chrysophanol Suppresses Cell Growth via mTOR/PPAR-alpha Regulation and ROS 
      Accumulation in Cultured Human Tongue Squamous Carcinoma SAS Cells.
PG  - 1528-1538
LID - 10.3390/cimb44040104 [doi]
AB  - Oral cancer, a type of head and neck cancer, can pose a significant risk of death 
      unless diagnosed and treated early. Alternative treatments are urgently needed 
      owing to the high mortality rate, limitations of conventional treatments, and 
      many complications. The anthraquinone compound chrysophanol acts as a tumor 
      suppressor on some types of cancer cells. To date, it has not been clarified how 
      chrysophanol affects human tongue squamous carcinoma. This study was aimed to 
      examine the effects of chrysophanol on oral cancer treatment. The results show 
      that chrysophanol caused cell death, reduced the expression of the mammalian 
      target of rapamycin (mTOR)/peroxisome proliferator-activated receptor-alpha 
      (PPAR-alpha), and increased reactive oxygen species (ROS) production. We also used 
      two ion chelators, deferoxamine (DFO) and liproxstatin-1 (Lipro), to further 
      determine whether chrysophanol inhibits cell growth and regulates mTOR/PPAR-alpha 
      expression and ROS production, both of which are involved in iron homeostasis. 
      The results show that DFO and Lipro reversed the increase in cell death, 
      downregulation of mTOR/PPAR-alpha, and decrease in ROS accumulation. In conclusion, 
      chrysophanol inhibits the growth of oral squamous cell carcinoma cells by 
      modulating mTOR/PPAR-alpha and by causing ROS accumulation.
FAU - Hsu, Po-Chih
AU  - Hsu PC
AD  - Department of Dentistry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical 
      Foundation, New Taipei City 231, Taiwan.
AD  - Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 
      114, Taiwan.
FAU - Hsu, Chia-Chen
AU  - Hsu CC
AD  - Department of Dentistry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical 
      Foundation, New Taipei City 231, Taiwan.
AD  - Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical 
      Foundation, New Taipei City 231, Taiwan.
FAU - Hsia, Yi-Jan
AU  - Hsia YJ
AD  - Department of Dentistry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical 
      Foundation, New Taipei City 231, Taiwan.
FAU - Kuo, Chan-Yen
AU  - Kuo CY
AUID- ORCID: 0000-0002-5702-5730
AD  - Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical 
      Foundation, New Taipei City 231, Taiwan.
LA  - eng
GR  - TCRD-TPE-110-RT-3/Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation 
      and New Taipei City, Taiwan/
PT  - Journal Article
DEP - 20220401
PL  - Switzerland
TA  - Curr Issues Mol Biol
JT  - Current issues in molecular biology
JID - 100931761
PMC - PMC9164035
OTO - NOTNLM
OT  - chrysophanol
OT  - mammalian target of rapamycin (mTOR)
OT  - oral squamous cell carcinoma (OSCC)
OT  - peroxisome proliferator-activated receptor-alpha (PPAR-alpha)
OT  - reactive oxygen species (ROS)
COIS- The authors declare that there are no conflict of interest regarding the 
      publication of this paper.
EDAT- 2022/06/21 06:00
MHDA- 2022/06/21 06:01
PMCR- 2022/04/01
CRDT- 2022/06/20 08:24
PHST- 2022/02/23 00:00 [received]
PHST- 2022/03/29 00:00 [revised]
PHST- 2022/04/01 00:00 [accepted]
PHST- 2022/06/20 08:24 [entrez]
PHST- 2022/06/21 06:00 [pubmed]
PHST- 2022/06/21 06:01 [medline]
PHST- 2022/04/01 00:00 [pmc-release]
AID - cimb44040104 [pii]
AID - cimb-44-00104 [pii]
AID - 10.3390/cimb44040104 [doi]
PST - epublish
SO  - Curr Issues Mol Biol. 2022 Apr 1;44(4):1528-1538. doi: 10.3390/cimb44040104.