PMID- 35723372
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 1467-3045 (Electronic)
IS  - 1467-3037 (Print)
IS  - 1467-3037 (Linking)
VI  - 44
IP  - 4
DP  - 2022 Apr 11
TI  - The Increase in Circulating Levels of Pro-Inflammatory Chemokines, Cytokines, and 
      Complement C5 in Canines with Impaired Kidney Function.
PG  - 1664-1676
LID - 10.3390/cimb44040114 [doi]
AB  - Chronic low-grade inflammation is a key contributor to the progression of kidney 
      disease. The release of cytokines and other pro-inflammatory proteins may further 
      contribute to detrimental kidney health by increasing interstitial edema and 
      renal fibrosis. The aim of the present study was to investigate the inflammatory 
      markers in canines who developed renal disease naturally and were diagnosed with 
      renal disease either during life or following necropsy, as assessed by a 
      veterinarian. RNA was isolated from canine blood obtained at necropsy and stored 
      as bioarchived samples from ten canines with renal disease (9.6-14.7 yr) and ten 
      controls (10.1-14.8 yr). At the time of death, the mean blood creatinine 
      concentration and BUN were elevated in dogs with renal disease compared to 
      control (both p < 0.01). Samples were assessed for changes in gene expression 
      using the Canine cytokine RT2 Profiler PCR Array for inflammation. There was a 
      significant increase in C-C Motif Chemokine Ligand 16 (CCL16), C-X-C Motif 
      Chemokine Ligand 5 (CXCL5), Interleukin 16 (IL-16), and Complement Component 5 
      (C5) (all p < 0.05 vs. con). In addition, there was also a statistically 
      non-significant increase in 49 genes and a down-regulation in 35 genes from a 
      panel of total 84 genes. Pro-inflammatory genes including CCL16, CXCL5, IL-16, 
      and C5 can all contribute to renal inflammation and fibrosis through different 
      signaling pathways and may lead to a progressive impairment of kidney function. 
      Blockade of their activation may be important in ameliorating the initiation 
      and/or the progression of renal disease.
FAU - Tavener, Selena K
AU  - Tavener SK
AD  - Science & Technology Center, Hill's Pet Nutrition, Inc., Topeka, KS 66617, USA.
FAU - Jewell, Dennis E
AU  - Jewell DE
AUID- ORCID: 0000-0003-2305-1014
AD  - Department of Grain Science & Industry, Kansas State University, Manhattan, KS 
      66506, USA.
FAU - Panickar, Kiran S
AU  - Panickar KS
AD  - Science & Technology Center, Hill's Pet Nutrition, Inc., Topeka, KS 66617, USA.
LA  - eng
PT  - Journal Article
DEP - 20220411
PL  - Switzerland
TA  - Curr Issues Mol Biol
JT  - Current issues in molecular biology
JID - 100931761
PMC - PMC9164022
OTO - NOTNLM
OT  - PCR
OT  - histopathology
OT  - immune
OT  - inflammation
OT  - renal
COIS- S.K.T. and K.S.P. are employees of Hills Pet Nutrition Center (Hills PNC), a 
      Colgate-Palmolive Company. D.E.J. is a previous employee of Hills PNC.
EDAT- 2022/06/21 06:00
MHDA- 2022/06/21 06:01
PMCR- 2022/04/11
CRDT- 2022/06/20 08:24
PHST- 2022/03/02 00:00 [received]
PHST- 2022/04/04 00:00 [revised]
PHST- 2022/04/05 00:00 [accepted]
PHST- 2022/06/20 08:24 [entrez]
PHST- 2022/06/21 06:00 [pubmed]
PHST- 2022/06/21 06:01 [medline]
PHST- 2022/04/11 00:00 [pmc-release]
AID - cimb44040114 [pii]
AID - cimb-44-00114 [pii]
AID - 10.3390/cimb44040114 [doi]
PST - epublish
SO  - Curr Issues Mol Biol. 2022 Apr 11;44(4):1664-1676. doi: 10.3390/cimb44040114.