PMID- 35723643
OWN - NLM
STAT- MEDLINE
DCOM- 20230215
LR  - 20230215
IS  - 1122-0643 (Print)
IS  - 1122-0643 (Linking)
VI  - 93
IP  - 1
DP  - 2022 Jun 20
TI  - Pulmonary rehabilitation: A novel adjunct in management of obstructive sleep 
      apnea.
LID - 10.4081/monaldi.2022.2260 [doi]
AB  - Pulmonary rehabilitation (PR) is being used in the routine management of patients 
      of obstructive sleep apnea (OSA) at some centers. However, the studies 
      documenting benefits of PR in OSA lack standardization in terms of outcome 
      measures. A study was hence planned to determine the efficacy of PR on exercise 
      capacity, health related quality of life (HRQOL), day time sleepiness and 
      sleep-quality of life (QOL) in patients of OSA. As a part of comprehensive 
      therapy, patients diagnosed with OSA are managed with continuous positive airway 
      pressure (CPAP), 8 weeks thrice weekly outpatient hospital-based PR and medical 
      treatment at the Pulmonary Medicine Department, Government Medical College and 
      Hospital, Chandigarh. However, some patients refuse for PR because of time 
      constraints and travel issues. Patients with newly diagnosed OSA without 
      co-existing respiratory disease, who agreed for the CPAP, PR and medical 
      management were enrolled in group A. The patients who refused for PR but were 
      ready for CPAP and medical management were enrolled in Group B; 30 patients were 
      taken in each group. Exercise capacity, HRQOL, day time sleepiness and sleep-QOL 
      were determined at baseline and at 8-weeks follow-up by 6-minute walk distance 
      (6MWD), St. George's Respiratory Questionnaire (SGRQ), Epworth Sleepiness Scale 
      (ESS) and Functional Outcomes of Sleep Questionnaire (FOSQ) and compared amongst 
      the two groups. Four patients from group A were excluded as they did not complete 
      PR; 26 patients from group A and 30 patients from group B were finally analyzed. 
      At baseline, both groups were matched with respect to age, gender, apnea-hypopnea 
      index (AHI), body mass index (BMI), FEV1%predicted, 6MWD, SGRQ, ESS and FOSQ. At 
      follow up at 8 weeks, BMI, 6MWD, SGRQ, ESS and FOSQ improved significantly from 
      baseline in group A (p<0.001). FEV1%predicted also improved but non 
      significantly. In group B, FEV1%predicted, BMI, 6MWD, SGRQ, ESS and FOSQ score 
      did not improve significantly from baseline. Mean improvement from baseline in 
      BMI, 6MWD, SGRQ, ESS and FOSQ was significantly more in group A than group B 
      (p<0.001, p<0.001, p=0.041, p<0.001 and p<0.001, respectively). PR, being 
      beneficial, should be incorporated in standard management of OSA.
FAU - Agarwal, Prakhar
AU  - Agarwal P
AD  - Department of Pulmonary Medicine Critical Care and Sleep Medicine, All India 
      Institute of Medical Sciences, Bhopal. praksag21@gmail.com.
FAU - Garg, Kranti
AU  - Garg K
AD  - Department of Pulmonary Medicine, Government Medical College, Patiala. 
      drkrantigarg@yahoo.com.
FAU - Saini, Varinder
AU  - Saini V
AD  - Department of Pulmonary Medicine, Government Medical College and Hospital, Sector 
      32, Chandigarh. varindersaini62@gmail.com.
FAU - Singh, Isha
AU  - Singh I
AD  - Business Administration in Hospital Management, Panjab University, Chandigarh. 
      singhishasingh25@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220620
PL  - Italy
TA  - Monaldi Arch Chest Dis
JT  - Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
JID - 9307314
SB  - IM
MH  - Humans
MH  - *Quality of Life
MH  - Treatment Outcome
MH  - Sleepiness
MH  - *Sleep Apnea, Obstructive/therapy/diagnosis
MH  - Outcome Assessment, Health Care
EDAT- 2022/06/21 06:00
MHDA- 2023/02/16 06:00
CRDT- 2022/06/20 10:33
PHST- 2022/03/09 00:00 [received]
PHST- 2022/06/10 00:00 [accepted]
PHST- 2022/06/21 06:00 [pubmed]
PHST- 2023/02/16 06:00 [medline]
PHST- 2022/06/20 10:33 [entrez]
AID - 10.4081/monaldi.2022.2260 [doi]
PST - epublish
SO  - Monaldi Arch Chest Dis. 2022 Jun 20;93(1). doi: 10.4081/monaldi.2022.2260.