PMID- 35725165 OWN - NLM STAT- MEDLINE DCOM- 20220622 LR - 20220622 IS - 1879-1344 (Electronic) IS - 0144-8617 (Linking) VI - 292 DP - 2022 Sep 15 TI - Recent advances in hyaluronic acid-based nanomedicines: Preparation and application in cancer therapy. PG - 119662 LID - S0144-8617(22)00567-7 [pii] LID - 10.1016/j.carbpol.2022.119662 [doi] AB - Rapid development of stimuli-responsive drug delivery systems (DDSs) for tumor therapy has raised increasing interest in recent decades, and many nanomedicines are prepared to achieve accurate or sustained drug release. However, the fabrication process for these nanomedicines has been far too intricate and their potential biosafety has not been fully understood, which has hampered their clinical translation. Challenges for developing DDSs remain on balancing the complexity of the fabrication process with their translational feasibility. Owing to water-solubility, biocompatibility, biodegradability and CD44-targetability, hyaluronic acid (HA) as a versatile building block has gained great popularity due to a simplified fabrication process and unique characteristics of HA for DDSs. In this review, we overviewed the biological function and multiple chemical modifications of HA, and discussed the fabrication of HA-based drug delivery systems (HA-DDSs) with specific tumor microenvironmental stimuli-responsive linkers. We systemically surveyed the applications of HA-DDSs for chemotherapy, photothermal therapy, photodynamic therapy, immunotherapy, gene delivery and combination therapy. CI - Copyright (c) 2022. Published by Elsevier Ltd. FAU - Hou, Xingyu AU - Hou X AD - Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Zhong, Dan AU - Zhong D AD - Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Chen, Hongying AU - Chen H AD - Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Gu, Zhongwei AU - Gu Z AD - Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China; Functional and Molecular Imaging Key Laboratory of Sichuan Province, Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, 610041, China. FAU - Gong, Qiyong AU - Gong Q AD - Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China; Functional and Molecular Imaging Key Laboratory of Sichuan Province, Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, 610041, China. FAU - Ma, Xuelei AU - Ma X AD - Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: maxuelei0726@wchscu.cn. FAU - Zhang, Hu AU - Zhang H AD - Amgen Bioprocessing Centre, Keck Graduate Institute, Claremont, CA 91711, USA. FAU - Zhu, Hongyan AU - Zhu H AD - Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Luo, Kui AU - Luo K AD - Laboratory of Stem Cell Biology, Huaxi MR Research Center (HMRRC), Department of Radiology, Department of Biotherapy, Research Core Facilities of West China Hospital, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China; Functional and Molecular Imaging Key Laboratory of Sichuan Province, Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, 610041, China. Electronic address: luokui@scu.edu.cn. LA - eng PT - Journal Article PT - Review DEP - 20220527 PL - England TA - Carbohydr Polym JT - Carbohydrate polymers JID - 8307156 RN - 9004-61-9 (Hyaluronic Acid) SB - IM MH - Drug Delivery Systems MH - Humans MH - Hyaluronic Acid/therapeutic use MH - Nanomedicine MH - *Neoplasms/drug therapy/pathology MH - *Photochemotherapy OTO - NOTNLM OT - Anti-tumor therapy OT - Drug delivery systems OT - Hyaluronic acid OT - Nanomedicines OT - Stimuli-responsive EDAT- 2022/06/21 06:00 MHDA- 2022/06/23 06:00 CRDT- 2022/06/20 21:05 PHST- 2022/03/29 00:00 [received] PHST- 2022/05/06 00:00 [revised] PHST- 2022/05/23 00:00 [accepted] PHST- 2022/06/20 21:05 [entrez] PHST- 2022/06/21 06:00 [pubmed] PHST- 2022/06/23 06:00 [medline] AID - S0144-8617(22)00567-7 [pii] AID - 10.1016/j.carbpol.2022.119662 [doi] PST - ppublish SO - Carbohydr Polym. 2022 Sep 15;292:119662. doi: 10.1016/j.carbpol.2022.119662. Epub 2022 May 27.