PMID- 35725662
OWN - NLM
STAT- MEDLINE
DCOM- 20240405
LR  - 20240405
IS  - 1097-6841 (Electronic)
IS  - 0022-3913 (Linking)
VI  - 131
IP  - 4
DP  - 2024 Apr
TI  - Is temporomandibular joint involvement more frequent in patients with epilepsy? A 
      clinical study.
PG  - 626-632
LID - S0022-3913(22)00203-7 [pii]
LID - 10.1016/j.prosdent.2022.03.022 [doi]
AB  - STATEMENT OF PROBLEM: Epileptic seizures may affect the stomatognathic system via 
      transmission of an increased load to the dentition and the temporomandibular 
      joint (TMJ), resulting in temporomandibular joint dysfunction (TMD). PURPOSE: The 
      purpose of this clinical study was to assess whether TMD was more prevalent in 
      patients with epilepsy than in those without epilepsy. MATERIAL AND METHODS: A 
      total of 107 participants diagnosed with epilepsy and 100 healthy controls were 
      enrolled in the study. Those with epilepsy were divided according to their dental 
      manageability into 3 subgroups: mild group, moderate group, and severe group. 
      Following general, dental, and TMJ-related history, the range of maximal mouth 
      opening (MMO), laterotrusion, possible deviation and deflection, and presence of 
      crepitation and clicking was recorded, as suggested by the diagnostic criteria 
      for temporomandibular diseases (DC/TMD). Pressure pain threshold (PPT) was also 
      measured by using a pressure algometer on 3 points bilaterally. RESULTS: 
      Incidence of TMJ complaints was not significantly different between the control 
      (30%) and the group diagnosed with epilepsy (33%); however, the number of 
      complaints experienced was significantly higher in the epilepsy group (C: 3%, E: 
      16% had 3 or more complaints; P<.001). Joint clicking was significantly more 
      prevalent in the entire epilepsy group (P=.012) and in the mild group (P=.004) 
      than in controls. Crepitation and joint pain were not significantly more common 
      in the epilepsy group. Maximal mouth opening, laterotrusion, and the ratio of 
      restricted mouth opening did not differ significantly in the epilepsy group. 
      Deflection occurred significantly more often in the epilepsy subgroups (mild and 
      moderate groups; P<.001), and the extent of deflection was also significantly 
      higher in all the epilepsy subgroups (P<.001) than in controls. Regarding the 
      pressure pain threshold, significant difference was observed in the severe group 
      at the left masseter muscle points M1 (P=.046) and M2 (P=.028) compared with 
      controls. CONCLUSIONS: All parameters typical of TMD could be found frequently in 
      patients with epilepsy. Because of the seizures and the consequent joint 
      overload, the TMJ involvement was more common or more serious in those diagnosed 
      with epilepsy. Outcomes of this study support the assumption that epilepsy is a 
      risk factor for the development of TMD.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Karolyhazy, Katalin
AU  - Karolyhazy K
AD  - Associate Professor, Department of Prosthetic Dentistry, Faculty of Dentistry, 
      Semmelweis University, Budapest, Hungary.
FAU - Vass, Andrea Fanni
AU  - Vass AF
AD  - Assistant Professor, Department of General Dental Preclinical Practice, Faculty 
      of Dentistry, Semmelweis University, Budapest, Hungary. Electronic address: 
      vass.andrea_fanni@dent.semmelweis-univ.hu.
FAU - Csillik, Anita
AU  - Csillik A
AD  - Assistant Lecturer, Department of Neurology, Faculty of Medicine, Semmelweis 
      University, Budapest, Hungary.
FAU - Schmidt, Peter
AU  - Schmidt P
AD  - Vice-Director, Department of Prosthetic Dentistry, Faculty of Dentistry, 
      Semmelweis University, Budapest, Hungary.
FAU - Marton, Krisztina
AU  - Marton K
AD  - Associate Professor and Head of Department, Department of General Dental 
      Preclinical Practice, Faculty of Dentistry, Semmelweis University, Budapest, 
      Hungary.
LA  - eng
PT  - Journal Article
DEP - 20220617
PL  - United States
TA  - J Prosthet Dent
JT  - The Journal of prosthetic dentistry
JID - 0376364
SB  - IM
MH  - Humans
MH  - Temporomandibular Joint
MH  - *Temporomandibular Joint Disorders/diagnosis
MH  - Risk Factors
MH  - *Epilepsy/complications
MH  - Masseter Muscle
EDAT- 2022/06/21 06:00
MHDA- 2024/04/05 06:44
CRDT- 2022/06/20 23:50
PHST- 2021/04/25 00:00 [received]
PHST- 2022/03/20 00:00 [revised]
PHST- 2022/03/21 00:00 [accepted]
PHST- 2024/04/05 06:44 [medline]
PHST- 2022/06/21 06:00 [pubmed]
PHST- 2022/06/20 23:50 [entrez]
AID - S0022-3913(22)00203-7 [pii]
AID - 10.1016/j.prosdent.2022.03.022 [doi]
PST - ppublish
SO  - J Prosthet Dent. 2024 Apr;131(4):626-632. doi: 10.1016/j.prosdent.2022.03.022. 
      Epub 2022 Jun 17.