PMID- 35726908
OWN - NLM
STAT- MEDLINE
DCOM- 20220713
LR  - 20220713
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 147
IP  - 14
DP  - 2022 Jul 12
TI  - Polydopamine-based molecularly imprinted electrochemical sensor for the highly 
      selective determination of ecstasy components.
PG  - 3291-3297
LID - 10.1039/d2an00351a [doi]
AB  - 3,4-Methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA) 
      are the main components of illicit stimulant drugs, also known as "ecstasy", 
      which belong to psychoactive medicine and tend to be increasingly abused among 
      drug addicts worldwide. Herein, an electrochemical sensor based on molecularly 
      imprinted polydopamine (MIP@PDA) was developed to detect MDA and MDMA using 
      differential pulse voltammetry (DPV). An MIP film on a Au electrode was 
      synthesized via electrochemical polymerization with the safe chemical DA as the 
      polymerization monomer and the uncontrolled pharmaceutical intermediate 
      3,4-methylenedioxyphenethylamine (MDPEA) as the template molecule, which can 
      provide a great quantity of specific binding sites and expand the practical 
      application of the sensor. Due to the superior affinity of MIP@PDA to the target, 
      the proposed sensor displayed excellent analytical performance, with LODs of 37 
      nM and 54 nM for the determination of MDA and MDMA, respectively. Additionally, 
      this sensor presented suitable selectivity, stability, reproducibility and 
      detection ability in practical urine samples, which suggested that it is a 
      promising candidate as a rapid diagnostic method in drug investigations.
FAU - Li, Chen
AU  - Li C
AUID- ORCID: 0000-0001-9285-4430
AD  - Guangzhou Key Laboratory of Sensing Materials & Devices, Center for Advanced 
      Analytical Science, School of Chemistry and Chemical Engineering, c/o School of 
      Civil Engineering, Guangzhou University, Guangzhou 510006, PR China. 
      dxhan@gzhu.edu.cn.
FAU - Han, Dongfang
AU  - Han D
AD  - Guangzhou Key Laboratory of Sensing Materials & Devices, Center for Advanced 
      Analytical Science, School of Chemistry and Chemical Engineering, c/o School of 
      Civil Engineering, Guangzhou University, Guangzhou 510006, PR China. 
      dxhan@gzhu.edu.cn.
FAU - Wu, Zhifang
AU  - Wu Z
AD  - Guangzhou Key Laboratory of Sensing Materials & Devices, Center for Advanced 
      Analytical Science, School of Chemistry and Chemical Engineering, c/o School of 
      Civil Engineering, Guangzhou University, Guangzhou 510006, PR China. 
      dxhan@gzhu.edu.cn.
FAU - Liang, Zhishan
AU  - Liang Z
AD  - Guangzhou Key Laboratory of Sensing Materials & Devices, Center for Advanced 
      Analytical Science, School of Chemistry and Chemical Engineering, c/o School of 
      Civil Engineering, Guangzhou University, Guangzhou 510006, PR China. 
      dxhan@gzhu.edu.cn.
FAU - Han, Fangjie
AU  - Han F
AD  - Guangzhou Key Laboratory of Sensing Materials & Devices, Center for Advanced 
      Analytical Science, School of Chemistry and Chemical Engineering, c/o School of 
      Civil Engineering, Guangzhou University, Guangzhou 510006, PR China. 
      dxhan@gzhu.edu.cn.
FAU - Chen, Ke
AU  - Chen K
AD  - Guangzhou Key Laboratory of Sensing Materials & Devices, Center for Advanced 
      Analytical Science, School of Chemistry and Chemical Engineering, c/o School of 
      Civil Engineering, Guangzhou University, Guangzhou 510006, PR China. 
      dxhan@gzhu.edu.cn.
FAU - Fu, Wencai
AU  - Fu W
AD  - Guangzhou Key Laboratory of Sensing Materials & Devices, Center for Advanced 
      Analytical Science, School of Chemistry and Chemical Engineering, c/o School of 
      Civil Engineering, Guangzhou University, Guangzhou 510006, PR China. 
      dxhan@gzhu.edu.cn.
FAU - Han, Dongxue
AU  - Han D
AUID- ORCID: 0000-0002-7343-2221
AD  - Guangzhou Key Laboratory of Sensing Materials & Devices, Center for Advanced 
      Analytical Science, School of Chemistry and Chemical Engineering, c/o School of 
      Civil Engineering, Guangzhou University, Guangzhou 510006, PR China. 
      dxhan@gzhu.edu.cn.
AD  - Guangdong Provincial Key Laboratory of Psychoactive Substances Monitoring and 
      Safety, Anti-Drug Technology Center of Guangdong Province, Guangzhou 510230, PR 
      China. gdgawhk@163.com.
FAU - Wang, Yukai
AU  - Wang Y
AD  - Guangdong Provincial Key Laboratory of Psychoactive Substances Monitoring and 
      Safety, Anti-Drug Technology Center of Guangdong Province, Guangzhou 510230, PR 
      China. gdgawhk@163.com.
FAU - Niu, Li
AU  - Niu L
AUID- ORCID: 0000-0003-3652-2903
AD  - Guangzhou Key Laboratory of Sensing Materials & Devices, Center for Advanced 
      Analytical Science, School of Chemistry and Chemical Engineering, c/o School of 
      Civil Engineering, Guangzhou University, Guangzhou 510006, PR China. 
      dxhan@gzhu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220712
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
RN  - 0 (Indoles)
RN  - 0 (Polymers)
RN  - 0 (polydopamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Electrochemical Techniques/methods
MH  - Electrodes
MH  - Indoles
MH  - Limit of Detection
MH  - *Molecular Imprinting/methods
MH  - *N-Methyl-3,4-methylenedioxyamphetamine
MH  - Polymers
MH  - Reproducibility of Results
EDAT- 2022/06/22 06:00
MHDA- 2022/07/14 06:00
CRDT- 2022/06/21 08:23
PHST- 2022/06/22 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/06/21 08:23 [entrez]
AID - 10.1039/d2an00351a [doi]
PST - epublish
SO  - Analyst. 2022 Jul 12;147(14):3291-3297. doi: 10.1039/d2an00351a.