PMID- 35727527
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20230619
IS  - 0973-7693 (Electronic)
IS  - 0019-5456 (Linking)
VI  - 90
IP  - 7
DP  - 2023 Jul
TI  - The Influence of Non-E. Coli or Extended-Spectrum beta-Lactamase-Producing Bacterial 
      Growth on the Follow-Up Procedure of Infants with the First Febrile Urinary Tract 
      Infection.
PG  - 677-682
LID - 10.1007/s12098-022-04183-3 [doi]
AB  - OBJECTIVE: To evaluate the effects of non-E. coli or extended-spectrum 
      beta-lactamase-positive (ESBL-positive) microorganism growth in the first febrile 
      urinary tract infection (UTI) of infants on laboratory findings or renal 
      parenchymal damage presenting the severity of inflammation, anatomic 
      abnormalities defined by imaging studies, and recurrent UTIs in the follow-up 
      period. METHODS: The data of patients aged between 2 and 24 mo and followed up 
      for at least 6 mo with febrile UTI guideline of the authors' pediatric-nephrology 
      clinic, were retrospectively analyzed. Ultrasonography was performed in all the 
      cases at the time of UTI and dimercaptosuccinic-acid (DMSA) at least 4 mo after 
      the infection. Voiding cystourethrography (VCUG) was performed only if 
      ultrasonography findings were abnormal, the uptake deformity was detected in DMSA 
      scan, or the patients experienced recurrent UTIs. The patients were grouped 
      concerning E. coli or non-E. coli and ESBL-PB or non-ESBL-BP growth in the urine 
      cultures. RESULTS: There were 277 infants followed up for 28.55 +/- 15.24 (6-86) 
      mo. The causative microorganisms were non-E. coli in 73 (26.4%) and ESBL-PB in 58 
      (20.9%) cases. CRP values, pyuria, and leukocyte-esterase positivity were 
      significantly higher in UTIs caused by E. coli compared to non-E. coli bacteria. 
      All clinical and laboratory findings were similar between the ESBL-PB and 
      non-ESBL groups, but abnormal ultrasonography findings were more common in non-E. 
      coli group. CONCLUSION: E. coli causes more severe inflammation, but non-E. coli 
      infections are more frequently associated with ultrasound abnormalities. However, 
      ESBL production did not affect either laboratory or radiological findings in the 
      present cohort.
CI  - (c) 2022. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation.
FAU - Kavruk, Mustafa
AU  - Kavruk M
AD  - Department of Pediatrics, University of Health Sciences, Izmir Tepecik Training 
      and Research Hospital, Izmir, Turkey.
FAU - Soyaltin, Eren
AU  - Soyaltin E
AD  - Department of Pediatrics, Division of Nephrology, University of Health Sciences, 
      Izmir Tepecik Training and Research Hospital, Izmir, 35320, Turkey.
FAU - Erfidan, Gokcen
AU  - Erfidan G
AD  - Department of Pediatrics, Division of Nephrology, University of Health Sciences, 
      Izmir Tepecik Training and Research Hospital, Izmir, 35320, Turkey.
FAU - Arslansoyu Camlar, Secil
AU  - Arslansoyu Camlar S
AD  - Department of Pediatrics, Division of Nephrology, University of Health Sciences, 
      Izmir Tepecik Training and Research Hospital, Izmir, 35320, Turkey. 
      secilars@yahoo.com.
FAU - Alaygut, Demet
AU  - Alaygut D
AD  - Department of Pediatrics, Division of Nephrology, University of Health Sciences, 
      Izmir Tepecik Training and Research Hospital, Izmir, 35320, Turkey.
FAU - Mutlubas, Fatma
AU  - Mutlubas F
AD  - Department of Pediatrics, Division of Nephrology, University of Health Sciences, 
      Izmir Tepecik Training and Research Hospital, Izmir, 35320, Turkey.
FAU - Yilmaz, Nisel
AU  - Yilmaz N
AD  - Department of Clinical Microbiology, University of Health Sciences, Izmir Tepecik 
      Training and Research Hospital, Izmir, Turkey.
FAU - Kasap Demir, Belde
AU  - Kasap Demir B
AUID- ORCID: 0000-0002-5456-3509
AD  - Department of Pediatrics, Division of Nephrology, University of Health Sciences, 
      Izmir Tepecik Training and Research Hospital, Izmir, 35320, Turkey.
AD  - Department of Pediatrics, Division of Nephrology and Rheumatology, Izmir Katip 
      Celebi University Medical Faculty, Izmir, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220621
PL  - India
TA  - Indian J Pediatr
JT  - Indian journal of pediatrics
JID - 0417442
RN  - EC 3.5.2.6 (beta-Lactamases)
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Child
MH  - Humans
MH  - Infant
MH  - Child, Preschool
MH  - Adolescent
MH  - Young Adult
MH  - Adult
MH  - *Escherichia coli Infections/drug therapy/microbiology
MH  - Escherichia coli
MH  - Retrospective Studies
MH  - Follow-Up Studies
MH  - beta-Lactamases/pharmacology
MH  - *Urinary Tract Infections/microbiology
MH  - Inflammation
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Risk Factors
OTO - NOTNLM
OT  - Extended-spectrum beta-lactamase-producing bacteria
OT  - First febrile urinary tract infections
OT  - Infants
OT  - Non-E. coli
EDAT- 2022/06/22 06:00
MHDA- 2023/06/19 13:08
CRDT- 2022/06/21 11:24
PHST- 2021/05/27 00:00 [received]
PHST- 2022/01/27 00:00 [accepted]
PHST- 2023/06/19 13:08 [medline]
PHST- 2022/06/22 06:00 [pubmed]
PHST- 2022/06/21 11:24 [entrez]
AID - 10.1007/s12098-022-04183-3 [pii]
AID - 10.1007/s12098-022-04183-3 [doi]
PST - ppublish
SO  - Indian J Pediatr. 2023 Jul;90(7):677-682. doi: 10.1007/s12098-022-04183-3. Epub 
      2022 Jun 21.