PMID- 35727562
OWN - NLM
STAT- MEDLINE
DCOM- 20220810
LR  - 20220811
IS  - 1526-9914 (Electronic)
IS  - 1526-9914 (Linking)
VI  - 23
IP  - 8
DP  - 2022 Aug
TI  - Evaluation of the dosimetric and radiobiological parameters in four radiotherapy 
      regimens for synchronous bilateral breast cancer.
PG  - e13706
LID - 10.1002/acm2.13706 [doi]
LID - e13706
AB  - This study is to investigate the optimal treatment option for synchronous 
      bilateral breast cancer (SBBC) by comparing dosimetric and radiobiological 
      parameters of intensity-modulated radiotherapy (IMRT) and volumetric modulated 
      arc therapy (VMAT) plans using single and dual isocenters. Twenty patients with 
      SBBC without lymph node involvement were selected retrospectively. Four treatment 
      plans were generated for each patient using the Eclipse treatment planning system 
      (Varian Medical System, Palo Alto, CA, USA) following two delivery techniques 
      with two isocenter conditions-IMRT using a single isocenter (IMRT_Iso1), VMAT 
      using a single isocenter (VMAT_Iso1), IMRT using dual isocenters (IMRT_Iso2), and 
      VMAT using dual isocenters (VMAT_Iso2). A dose of 42.56 Gy in 16 fractions was 
      prescribed for the planning target volume (PTV). All plans were calculated using 
      the Acuros XB algorithm and a photon optimizer for a 6-MV beam of a Vital Beam 
      linear accelerator. PTV-related dosimetric parameters were analyzed. Further, the 
      homogeneity index, conformity index, and conformation number were computed to 
      evaluate plan quality. Dosimetric parameters were also measured for the organs at 
      risk (OARs). In addition, the equivalent uniform dose corresponding to an 
      equivalent dose related to a reference of 2 Gy per fraction, the tumor control 
      probability, and the normal tissue complication probability were calculated based 
      on the dose-volume histogram to investigate the radiobiological impact on PTV and 
      OARs. IMRT_Iso1 exhibited similar target coverage and a certain degree of 
      dosimetric improvement in OAR sparing compared to the other techniques. It also 
      exhibited some radiobiological improvement, albeit insignificant. Although 
      IMRT_Iso1 significantly increased monitor unit compared to VMAT_Iso1, which is 
      the best option in terms of delivery efficiency, there was only a 22% increase in 
      delivery time. Therefore, in conclusion, IMRT_Iso1, the complete treatment of 
      which can be completed using a single setup, is the most effective method for 
      treating SBBC.
CI  - (c) 2022 The Authors. Journal of Applied Clinical Medical Physics published by 
      Wiley Periodicals, LLC on behalf of The American Association of Physicists in 
      Medicine.
FAU - Kang, Sang-Won
AU  - Kang SW
AD  - Department of Radiation Oncology, Seoul National University Bundang Hospital, 
      Seongnam-si, Gyeonggi-do, Republic of Korea.
FAU - Kang, Seonghee
AU  - Kang S
AD  - Department of Radiation Oncology, Seoul National University Hospital, Seoul, 
      Republic of Korea.
FAU - Lee, Boram
AU  - Lee B
AD  - Department of Radiation Oncology, Seoul National University Bundang Hospital, 
      Seongnam-si, Gyeonggi-do, Republic of Korea.
FAU - Song, Changhoon
AU  - Song C
AD  - Department of Radiation Oncology, Seoul National University Bundang Hospital, 
      Seongnam-si, Gyeonggi-do, Republic of Korea.
FAU - Eom, Keun-Yong
AU  - Eom KY
AD  - Department of Radiation Oncology, Seoul National University Bundang Hospital, 
      Seongnam-si, Gyeonggi-do, Republic of Korea.
FAU - Jang, Bum-Sup
AU  - Jang BS
AD  - Department of Radiation Oncology, Seoul National University Bundang Hospital, 
      Seongnam-si, Gyeonggi-do, Republic of Korea.
FAU - Kim, In Ah
AU  - Kim IA
AD  - Department of Radiation Oncology, Seoul National University Bundang Hospital, 
      Seongnam-si, Gyeonggi-do, Republic of Korea.
FAU - Kim, Jae-Sung
AU  - Kim JS
AD  - Department of Radiation Oncology, Seoul National University Bundang Hospital, 
      Seongnam-si, Gyeonggi-do, Republic of Korea.
FAU - Cho, Woong
AU  - Cho W
AD  - Department of Radiation Oncology, Seoul National University Boramae Medical 
      Center, Seoul, Republic of Korea.
FAU - Shin, Dong-Suk
AU  - Shin DS
AD  - Proton Therapy Center, National Cancer Center, Goyang-si, Gyeonggi-do, Republic 
      of Korea.
FAU - Kim, Jin-Young
AU  - Kim JY
AD  - Departments of Radiation Oncology, Dongnam Institute of Radiological and Medical 
      Sciences, Busan, Republic of Korea.
FAU - Chung, Jin-Beom
AU  - Chung JB
AD  - Department of Radiation Oncology, Seoul National University Bundang Hospital, 
      Seongnam-si, Gyeonggi-do, Republic of Korea.
LA  - eng
GR  - 2014-00028/the Seoul National University Bundang Hospital (SNUBH) Research Fund/
GR  - 2020R1C1C100936611/National Research Foundation of Korea (NRF)/
PT  - Journal Article
DEP - 20220621
PL  - United States
TA  - J Appl Clin Med Phys
JT  - Journal of applied clinical medical physics
JID - 101089176
SB  - IM
MH  - *Breast Neoplasms/radiotherapy
MH  - Female
MH  - Humans
MH  - Organs at Risk
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/methods
MH  - *Radiotherapy, Intensity-Modulated/methods
MH  - Retrospective Studies
PMC - PMC9359036
OTO - NOTNLM
OT  - dosimetric parameters
OT  - intensity-modulated radiotherapy
OT  - radiobiological parameters
OT  - synchronous bilateral breast cancer
OT  - volumetric modulated arc therapy
EDAT- 2022/06/22 06:00
MHDA- 2022/08/11 06:00
PMCR- 2022/06/21
CRDT- 2022/06/21 11:24
PHST- 2022/05/18 00:00 [revised]
PHST- 2021/10/21 00:00 [received]
PHST- 2022/06/04 00:00 [accepted]
PHST- 2022/06/22 06:00 [pubmed]
PHST- 2022/08/11 06:00 [medline]
PHST- 2022/06/21 11:24 [entrez]
PHST- 2022/06/21 00:00 [pmc-release]
AID - ACM213706 [pii]
AID - 10.1002/acm2.13706 [doi]
PST - ppublish
SO  - J Appl Clin Med Phys. 2022 Aug;23(8):e13706. doi: 10.1002/acm2.13706. Epub 2022 
      Jun 21.