PMID- 35728530
OWN - NLM
STAT- MEDLINE
DCOM- 20220623
LR  - 20230309
IS  - 1879-0445 (Electronic)
IS  - 0960-9822 (Print)
IS  - 0960-9822 (Linking)
VI  - 32
IP  - 12
DP  - 2022 Jun 20
TI  - Autophagy: Identification of MTMR5 as a neuron-enriched suppressor.
PG  - R574-R577
LID - S0960-9822(22)00711-4 [pii]
LID - 10.1016/j.cub.2022.04.075 [doi]
AB  - A puzzle of autophagy in neurons is that, unlike in other cells, it is not 
      robustly induced by inhibition of mammalian target of rapamycin (mTOR). A new 
      study now solves this conundrum and establishes that myotubularin-related 
      phosphatase 5 limits the induction of neuronal autophagy by mTOR inhibitors.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Vogel, Maria Chalokh
AU  - Vogel MC
AD  - Department of Neuroscience, Perelman School of Medicine at the University of 
      Pennsylvania, Philadelphia, PA 19104, USA.
FAU - Maday, Sandra
AU  - Maday S
AD  - Department of Neuroscience, Perelman School of Medicine at the University of 
      Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: 
      smaday@pennmedicine.upenn.edu.
LA  - eng
GR  - R01 NS110716/NS/NINDS NIH HHS/United States
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
CON - Curr Biol. 2022 Jun 20;32(12):2581-2595.e6. PMID: 35580604
MH  - *Autophagy/physiology
MH  - Neurons/physiology
MH  - Sirolimus/pharmacology
MH  - *TOR Serine-Threonine Kinases/genetics
PMC - PMC9994184
MID - NIHMS1874563
COIS- Declaration of interests The authors declare no competing interests.
EDAT- 2022/06/22 06:00
MHDA- 2022/06/24 06:00
PMCR- 2023/03/08
CRDT- 2022/06/21 18:29
PHST- 2022/06/21 18:29 [entrez]
PHST- 2022/06/22 06:00 [pubmed]
PHST- 2022/06/24 06:00 [medline]
PHST- 2023/03/08 00:00 [pmc-release]
AID - S0960-9822(22)00711-4 [pii]
AID - 10.1016/j.cub.2022.04.075 [doi]
PST - ppublish
SO  - Curr Biol. 2022 Jun 20;32(12):R574-R577. doi: 10.1016/j.cub.2022.04.075.