PMID- 35728947
OWN - NLM
STAT- MEDLINE
DCOM- 20220623
LR  - 20220716
IS  - 2332-7812 (Electronic)
IS  - 2332-7812 (Linking)
VI  - 9
IP  - 4
DP  - 2022 Jul
TI  - Immune Response and Safety of SARS-CoV-2 mRNA-1273 Vaccine in Patients With 
      Myasthenia Gravis.
LID - 10.1212/NXI.0000000000200002 [doi]
LID - e200002
AB  - BACKGROUND AND OBJECTIVES: Evidence regarding the safety and efficacy of 
      messenger RNA (mRNA) vaccines in patients with myasthenia gravis (MG) after 
      immunosuppressive therapies is scarce. Our aim is to determine whether the 
      mRNA-1273 vaccine is safe and able to induce humoral and cellular responses in 
      patients with MG. METHODS: We performed an observational, longitudinal, 
      prospective study including 100 patients with MG of a referral center for MG in 
      our country, conducted from April 2021 to November 2021 during the vaccination 
      campaign. The mRNA-1273 vaccine was scheduled for all participants. Blood samples 
      were collected before vaccination and 3 months after a second dose. Clinical 
      changes in MG were measured using the MG activities of daily life score at 
      baseline and 1 week after the first and second doses. A surveillance of all 
      symptoms of coronavirus disease 2019 (COVID-19) was conducted throughout the 
      study. Humoral and cellular immune responses after vaccination were assessed 
      using a spike-antibody ELISA and interferon gamma release assay in plasma. The 
      primary outcomes were clinically significant changes in MG symptoms after 
      vaccination, adverse events (AEs), and seroconversion and T-cell immune response 
      rates. RESULTS: Ninety-nine patients completed the full vaccination schedule, and 
      98 had 2 blood samples taken. A statistically significant worsening of symptoms 
      was identified after the first and second doses of the mRNA-1273 vaccine, but 
      this was not clinically relevant. Mild AEs occurred in 14 patients after the 
      first dose and in 21 patients after the second dose. Eighty-seven patients 
      developed a humoral response and 72 patients showed a T-cell response after 
      vaccination. A combined therapy with prednisone and other immunosuppressive drugs 
      correlated with a lower seroconversion ratio (OR = 5.97, 95% CI 1.46-24.09, p = 
      0.015) and a lower T-cell response ratio (OR = 2.83, 95% CI 1.13-7.13, p = 
      0.024). DISCUSSION: Our findings indicate that the mRNA vaccination against 
      COVID-19 is safe in patients with MG and show no negative impact on the disease 
      course. Patients achieved high humoral and cellular immune response levels. 
      CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that patients 
      with MG receiving the mRNA-1273 vaccine did not show clinical worsening after 
      vaccination and that most of the patients achieved high cellular or immune 
      response levels.
CI  - Copyright (c) 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the American Academy of Neurology.
FAU - Reyes-Leiva, David
AU  - Reyes-Leiva D
AUID- ORCID: 0000-0001-6983-7130
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Lopez-Contreras, Joaquin
AU  - Lopez-Contreras J
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Moga, Esther
AU  - Moga E
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Pla-Junca, Francesc
AU  - Pla-Junca F
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Lynton-Pons, Elionor
AU  - Lynton-Pons E
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Rojas-Garcia, Ricardo
AU  - Rojas-Garcia R
AUID- ORCID: 0000-0003-1411-5573
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Turon-Sans, Janina
AU  - Turon-Sans J
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Querol, Luis
AU  - Querol L
AUID- ORCID: 0000-0002-4289-8264
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Olive, Montse
AU  - Olive M
AUID- ORCID: 0000-0001-5727-0165
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Alvarez-Velasco, Rodrigo
AU  - Alvarez-Velasco R
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Caballero-Avila, Marta
AU  - Caballero-Avila M
AUID- ORCID: 0000-0001-9850-8504
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Carbayo, Alvaro
AU  - Carbayo A
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Vesperinas-Castro, Ana
AU  - Vesperinas-Castro A
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Domingo, Pere
AU  - Domingo P
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Illa, Isabel
AU  - Illa I
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Gallardo, Eduard
AU  - Gallardo E
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain.
FAU - Cortes-Vicente, Elena
AU  - Cortes-Vicente E
AD  - From the Neuromuscular Diseases Unit (D.R.-L., R.R.-G., J.T.-S., L.Q., M.O., 
      R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.C.-V.), Department of Neurology, 
      Hospital de la Santa Creu i Sant Pau, "Departament de Medicina," Universitat 
      Autonoma de Barcelona; Neuromuscular Diseases Lab (D.R.-L., R.R.-G., J.T.-S., 
      L.Q., M.O., R.A.-V., M.C.-A., A.C., A.V.-C., I.I., E.G., E.C.-V.), Institut de 
      Recerca Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona; Centro de 
      Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) (D.R.-L., F.P.-J., 
      R.R.-G., J.T.-S., L.Q., M.O., R.A.-V., M.C.-A., A.C., I.I., E.G., E.C.-V.), 
      Valencia; Unidad de Enfermedades Infecciosas (J.L.-C., P.D.), Servicio de 
      Medicina Interna, Hospital de la Santa Creu i Sant Pau; and Department of 
      Immunology (E.M., E.L.-P.), Hospital de la Santa Creu i Sant Pau, Biomedical 
      Research Institute Sant Pau (IIB Sant Pau), Universitat Autonoma de Barcelona, 
      Spain. ecortes@santpau.cat.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20220621
PL  - United States
TA  - Neurol Neuroimmunol Neuroinflamm
JT  - Neurology(R) neuroimmunology & neuroinflammation
JID - 101636388
RN  - 0 (Antibodies, Viral)
RN  - EPK39PL4R4 (2019-nCoV Vaccine mRNA-1273)
SB  - IM
CIN - Neurol Neuroimmunol Neuroinflamm. 2022 Jun 21;9(4):. PMID: 35728948
MH  - *2019-nCoV Vaccine mRNA-1273/adverse effects/immunology
MH  - Antibodies, Viral/blood
MH  - *COVID-19/prevention & control
MH  - Humans
MH  - Immunity, Cellular
MH  - Immunity, Humoral
MH  - Longitudinal Studies
MH  - *Myasthenia Gravis/complications
MH  - Prospective Studies
MH  - SARS-CoV-2
MH  - T-Lymphocytes/immunology
PMC - PMC9219516
EDAT- 2022/06/22 06:00
MHDA- 2022/06/24 06:00
PMCR- 2022/06/20
CRDT- 2022/06/21 21:45
PHST- 2022/01/27 00:00 [received]
PHST- 2022/03/24 00:00 [accepted]
PHST- 2022/06/21 21:45 [entrez]
PHST- 2022/06/22 06:00 [pubmed]
PHST- 2022/06/24 06:00 [medline]
PHST- 2022/06/20 00:00 [pmc-release]
AID - 9/4/e200002 [pii]
AID - NXI-2022-200002 [pii]
AID - 10.1212/NXI.0000000000200002 [doi]
PST - epublish
SO  - Neurol Neuroimmunol Neuroinflamm. 2022 Jun 21;9(4):e200002. doi: 
      10.1212/NXI.0000000000200002. Print 2022 Jul.